Current Opinion in Organ Transplantation,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Sept. 27, 2022
Adequately
managing
a
complex
medical
regimen
is
paramount
to
the
success
of
organ
transplants.
When
patients
stray
from
their
prescribed
posttransplant,
graft
rejection,
and
death
can
occur.
Predictors
adherence
have
been
studied
for
many
years,
various
factors
identified
as
contributing
adequate
or
poor
adherence.
Both
demographic
personal
characteristics
associated
with
behavior.
However,
recent
developments,
such
COVID-19
pandemic,
increased
use
mobile
health
interventions,
biomarkers
affected
way
measured
applied.The
pandemic
patients'
comfort
accessing
outpatient
care
created
wider
telehealth
services.
Measurement
through
serum
lab
levels
continues
be
reviewed
potential
objective
assessment
Psychosocial
continue
major
contributors
nonadherence.Adherence
antirejection
medication,
work,
appointments,
exercise
dietary
instructions
remains
critical
transplant
patient.
It
that
providers
involved
in
selection
process
posttransplant
treatment
these
remain
well
informed
new
affecting
The Journal of Pediatrics,
Journal Year:
2023,
Volume and Issue:
261, P. 113580 - 113580
Published: June 21, 2023
To
inform
approaches
to
pediatric
medical
traumatic
stress
(PMTS)
by
exploring
providers'
(1)
perception
of
the
impact
PMTS
on
care
patients
with
pediatric-onset
chronic
illnesses,
(2)
self-reported
competencies
and
practices
prevention,
treatment,
counseling,
(3)
barriers
influencing
adoption
these
practices.A
convenience
sample
multidisciplinary
healthcare
providers
was
recruited
through
a
multimodal
recruitment
strategy
participate
in
an
electronic
survey
adapted
from
Trauma-Informed
Care
Provider
Survey.Among
participants
(n
=
304),
99%
agreed
that
impacts
patient
health.
Participants
report
altering
plans
due
PMTS,
including
deferring
or
stopping
treatments
98
[32%])
changing
medication
regimens
88
[29%]).
Sixty-eight
percent
208)
negative
implementation
plans,
nonadherence
153
[50%])
missed
appointments
119
[39%]).
Although
it
is
their
job
decrease
292
[96%])
perform
assessments
268
[88%]),
few
practiced
PMTS-focused
trauma
informed
care.
Systems-level
practice
included
insufficient
training,
absent
clinical
workflows,
lack
access
mental
health
experts.Our
findings
have
helped
conceptual
framework
for
understanding
relationship
between
outcomes.
opportunities
optimize
trauma-informed
include
dissemination
provider
integrated
workflows
mitigation,
enhanced
accessibility
providers.
Further
work
required
determine
if
interventions
can
improve
outcomes
illnesses.
Cell and Organ Transplantology,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: May 30, 2024
Cardiovascular
diseases
are
a
leading
cause
of
disability
and
mortality
among
the
working
population,
necessitating
development
implementation
new,
more
effective
treatment
rehabilitation
methods
for
such
patients,
including
use
modern
cellular
tissue
technologies.
In
this
review,
an
analysis
summary
research
results
over
past
decades
regarding
effectiveness
various
types
stem
cells
in
heart
pathology
were
conducted.
Priority
directions
include
search
accessible
safe
sources
cells,
new
their
cultivation,
scaffolds
transplantation.
Given
pathogenetic
mechanisms
cardiovascular
myocardial
regeneration,
particular
interest
clinical
application
is
drawn
to
tissue-specific
progenitors
from
myocardium
replacing
injured
cardiomyocytes,
endothelial
correcting
accompanying
dysfunction,
multipotent
mesenchymal
origins
with
low
immunogenicity
that
exhibit
trophic,
anti-inflammatory,
immunomodulatory,
anti-apoptotic
effects.
Questions
optimal
method,
dose,
frequency
cell
administration,
as
well
standardization
criteria
quality
effectiveness,
remain
open.
Additionally,
combined
different
may
serve
priority
strategy
assessing
safety
therapy,
especially
considering
paradigm
repeated
The
successful
translation
obtained
preclinical
into
further
large,
well-planned,
placebo-controlled
trials
will
enhance
therapy
diseases,
which
one
current
challenges
regenerative
medicine.
Journal of Pediatric Gastroenterology and Nutrition,
Journal Year:
2022,
Volume and Issue:
75(4), P. 455 - 461
Published: July 25, 2022
Objectives:
Known
as
pediatric
medical
traumatic
stress
(PMTS),
posttraumatic
symptoms
from
experiences
have
not
been
explored
in
children
with
chronic
gastrointestinal
diseases.
This
cross-sectional
study
of
and
adolescents
inflammatory
bowel
disease,
pancreatitis
cystic
fibrosis,
aimed
to
(1)
estimate
the
prevalence
potentially
events
(PTEs)
PMTS,
(2)
explore
potential
risk
factors
for
(3)
consequences
PMTS.
Methods:
used
validated,
self-report
measures
evaluate
PTEs
Descriptive
statistics
regression
analyses
were
achieve
objectives.
Results:
Over
two-thirds
reported
a
event
(91
132,
69%).
Forty-eight
had
PMTS
(36%).
was
associated
medication
burden,
emergency
intensive
care
visits,
parent
disorder
multivariate
analysis.
Potential
included
school
absenteeism,
home
opioid
use,
poor
quality
life,
missed
work.
Conclusions:
A
substantial
portion
our
cohort
The
exploratory
analysis
identified
associations
between
illness
factors,
disorder,
functional
impairments.
Further
studies
detection,
prevention
treatment
are
integral
optimizing
these
children’s
health
life.
Current Opinion in Organ Transplantation,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Sept. 14, 2022
Purpose
of
review
Social
support
has
many
benefits
for
patients
undergoing
organ
transplantation,
though
inclusion
it
as
criteria
transplant
listing
been
debated.
This
highlights
recent
developments
in
the
research
regarding
social
and
including
impact
on
transplantation
caregivers,
interventions,
COVID-19,
ethical
perspectives.
Recent
findings
perceived
have
patients,
increased
quality
life
adherence.
The
providers
may
also
be
impacted
vary
based
patient
caregiver
characteristics,
group
ethnicity.
Debates
COVID-19
vaccine
requirements
caregivers
concerns
about
are
explored.
Summary
Transplant
benefit
from
support,
additional
is
needed
outcomes
utility
use
listing.
There
a
need
more
robust
diverse
populations,
identification
supportive
interventions
caregivers.
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(2), P. 1122 - 1122
Published: Jan. 8, 2023
After
a
traumatic
medical
event,
such
as
surgery
or
hospitalization,
child
may
develop
phobia
of
care,
sometimes
preventing
future
adherence
and
impairing
recovery.
This
study
examined
the
correlation
Pediatric
Medical
Traumatic
Stress
(PMTS)
on
development
Phobia
(MP)
subsequent
treatment
adherence.
We
enrolled
152
parents
children
aged
1-6
hospitalized
in
surgical
ward.
During
completed
questionnaires
that
identified
post-traumatic
stress
symptoms.
Four
months
post
stress,
phobia,
psychosocial
variables
found
positive
between
PMTS
MP
low
to
treatment.
In
addition,
mediated
relationship
severity
adherence,
indicating
is
associated
with
stronger
lower
pediatric
Our
findings
suggest
serves
an
essential
component
PMTS.
It
important
add
syndrome
definition.
are
involved
rehabilitation
recovery
process
success,
it
aspect
Pediatric Transplantation,
Journal Year:
2024,
Volume and Issue:
28(6)
Published: Aug. 12, 2024
Solid
organ
transplant
recipients
experience
a
period
of
unique
vulnerability
during
adolescence,
when
normative
developmental
changes
intersect
with
health-related
variables
to
influence
psychological
health.
Transplantation,
Journal Year:
2022,
Volume and Issue:
107(4), P. 855 - 866
Published: Dec. 21, 2022
In
recent
decades,
the
number
of
pediatric
transplantations
and
their
survival
rates
have
increased.
Psychological
problems
poorer
quality
life
are
notable
among
children
undergoing
transplantation
can
long-lasting
consequences
affect
immunosuppressive
therapy
adherence.
Pet
ownership
animal
contact
been
associated
with
physical,
mental,
social
health
benefits.
Despite
these
potential
benefits,
however,
companion
animals
known
to
be
a
source
infection,
which
is
one
main
concerns
for
clinicians.
Because
immunosuppression,
particularly
vulnerable
infections.
Zoonoses
comprise
long
list
infectious
diseases
represent
major
public
problem.
Nevertheless,
many
families
most
healthcare
providers
unaware
risks,
there
worrisome
lack
recommendations
manage
risk-benefit
balance,
could
pose
risk
acquiring
zoonosis.
Furthermore,
no
data
available
on
transplanted
patients
pets,
this
balance
difficult
adequately
evaluate.
document,
we
review
currently
evidence
regarding
epidemiology
zoonotic
infections
in
transplantation,
focusing
from
perspective,
help
inform
decision-making
Families
professionals
should
aware
clinicians
actively
screen
pets
offer
comprehensive
information
as
part
routine
clinical
practice.
A
multidisciplinary
approach
will
ensure
proper
care
establish
preventive
measures
safe
living
pets.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 7, 2024
Abstract
Adverse
childhood
experiences
(ACE)
are
linked
to
several
health
issues
in
adulthood.
It
is
not
known
how
ACE
may
impact
solid
organ
transplant
outcomes.
We
hypothesized
that
associated
with
adverse
administered
a
10-item
inventory
questionnaire
48
patients
transplanted
as
children
and
transitioned
adult
services.
Mean
age
was
23
years,
54%
were
female,
19%
White.
Primary
outcome
current
functioning
graft.
60.4%
reported
an
score
of
>
0,
22.9%
3.
There
no
association
between
0
(P
=
0.3715)
or
3
0.5757)
graft
loss.
In
this
single
center
study,
we
did
find
outcomes
young
patients.
Further
studies
needed
elucidate
the
relationship
trauma
long-term
Pediatric Transplantation,
Journal Year:
2024,
Volume and Issue:
28(4)
Published: May 3, 2024
Abstract
Background
Adolescent
and
young
adult
(AYA)
solid
organ
transplant
(SOT)
recipients
experience
increased
rates
of
rejection
graft
loss
surrounding
the
time
health
care
transition,
in
part
due
to
poor
medication
adherence.
This
study
aims
examine
impact
a
once‐daily
formulation
tacrolimus,
LCP‐tacrolimus
(LCPT),
on
adherence
for
AYA
SOT
patients.
Methods
A
retrospective
descriptive
analysis
was
performed
all
patients
who
underwent
were
prescribed
LCPT
after
age
12
at
our
single‐center
pediatric
hospital.
Medication
assessed
via
provider
documentation
level
variability
index
(MLVI).
Results
Twenty‐nine
as
their
immunosuppression
regimen.
Twenty
converted
from
immediate‐acting
(IR)
tacrolimus;
six
initiated
immediately
following
transplant,
three
unable
receive
insurance
denial.
There
numeric
improvement
when
measured
by
assessment
(45.0%
vs.
68.4%,
p
=
.140)
MLVI
(40.0%
71.4%,
.276),
though
these
did
not
reach
statistical
significance.
no
differences
episodes
or
adverse
effects.
prescription
associated
with
decreased
burden,
two
transitioned
back
IR
tacrolimus
cost.
Conclusions
use
significantly
improve
patient
adherence;
however,
it
resulted
numerically
higher
perceived
rates.
appears
be
safe
effective
management
recipients;
may
affect
pill
burden
result
financial
burden.
Use
considered
select
group
recipients.