Pediatric Pulmonology,
Journal Year:
2021,
Volume and Issue:
57(1), P. 66 - 74
Published: Oct. 4, 2021
Abstract
Background
Lockdown
measures
during
the
SARS‐CoV‐2
pandemic
determined
radical
changes
to
behavioral
and
social
habits,
that
were
reflected
by
a
reduction
in
transmission
of
respiratory
pathogens
anthropogenic
atmospheric
emissions.
Objective
This
ecological
study
aims
provide
descriptive
evaluation
on
how
restrictive
impacted
Pediatric
Emergency
Department
(PED)
referrals
for
asthma
exacerbations,
their
potentially
associated
environmental
triggers
Bologna,
densely
populated
urban
area
Northern
Italy.
Methods
Files
children
evaluated
acute
2015
2020
at
PED
Sant'Orsola
University
Hospital
Bologna
retrospectively
reviewed.
Historical
daily
concentration
records
particulate
(PM
2.5
,
PM
10
)
gaseous
(NO
2
C
6
H
air
pollutants,
pollen
concurrently
evaluated,
including
specific
chemical
tracers
traffic‐related
pollution
(TRAP).
Results
In
2020,
asthma‐related
decreased
compared
referral
rates
previous
5
years
(
p
<
0.01).
effect
was
particularly
marked
first
lockdown
period
(March
May),
when
drastic
drop
with
high‐priority
cases
up
85%
54%,
average.
A
concomitant
concentrations
pollutants
observed
range
40%–60%
Conclusions
The
lower
rate
exacerbations
childhood
this
paralleled
reduced
TRAP
levels
pandemic.
Synergic
interactions
multiple
consequences
lockdowns
likely
contributed
exposure
ambient
fewer
infections,
identified
as
most
important
factor
literature.
The Medical Journal of Australia,
Journal Year:
2022,
Volume and Issue:
216(7), P. 364 - 372
Published: Jan. 23, 2022
▪In
this
narrative
review,
we
summarise
the
vast
and
burgeoning
research
on
potential
established
indirect
impacts
children
of
COVID-19
pandemic.
We
used
a
community
child
health
lens
to
organise
our
findings
consider
how
Australia
might
best
respond
needs
(aged
0-12
years).
▪We
synthesised
literature
previous
pandemics,
epidemics
natural
disasters,
current
found
clear
evidence
adverse
pandemic
that
either
repeated
or
extended
from
pandemics.
identified
11
impact
areas,
under
three
broad
categories:
child-level
factors
(poorer
mental
health,
poorer
development,
academic
achievement);
family-level
affect
parent
reduced
family
income
job
losses,
increased
household
stress,
abuse
neglect,
maternal
newborn
health);
service-level
(school
closures,
access
care,
use
technology
for
learning,
connection
care).
▪There
is
increasing
global
concern
about
likely
disproportionate
experiencing
adversity,
widening
existing
disparities
in
developmental
outcomes.
suggest
five
strategy
areas
could
begin
address
these
inequities:
addressing
financial
instability
through
supplements;
expanding
role
schools
learning
gaps
wellbeing;
rethinking
care
delivery
access;
focusing
prevention
early
intervention
health;
using
digital
solutions
inequitable
service
delivery.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(2), P. 356 - 356
Published: Jan. 9, 2025
Asthmatic
children
who
tested
positive
for
COVID-19
experienced
changes
in
lung
function
and
persistent
symptoms
following
SARS-CoV-2
infection,
even
several
months
after
diagnosis,
with
the
same
features
as
an
acute
phase.
This
study
aimed
to
analyze
a
pediatric
age
group
(between
0
17
years
old)
diagnosed
asthma,
infection
attending
regular
monitoring
visits
Pediatric
Department
of
Regional
Tertiary
Hospital
(Filantropia
Clinical
Municipal
Craiova,
Romania)
during
pandemic
post-pandemic
time
interval
(i.e.,
March
2020-July
2024),
identify
how
influenced
their
long-term
treatment.
Materials
Methods.
The
variables
were
recorded:
demographic
data
(gender,
group,
residence),
related
allergies
(allergic
rhinitis,
atopic
dermatitis,
food
allergies),
presence
exacerbations,
fraction
exhaled
nitric
oxide,
ventilatory
function,
asthma
phenotype
or
non-allergic),
well
GINA
assessment
control
at
clinical
analyzed.
infections
evaluated
terms
year
symptoms,
cough
persistence,
modifications
treatment
disease.
statistically
analyzed
SPSS,
using
Mann-Whitney
U,
Kruskal-Wallis
H,
Chi-Square
tests.
Results.
A
lower
incidence
cases
was
recorded
first
asthmatic
patients
(2020
2021),
but
increase
rate
observed
beginning
second
pandemic,
2022.
oxide
values
infected
significantly
increased
(p
<
0.0005),
especially
more
than
4
weeks.
significant
number
exacerbations
also
0.0005).
Ventilatory
different
without
0.05).
Conclusions.
persistence
phase
tests
emphasize
need
periodic
medical
check-ups,
implementation
therapeutic
regimen
appropriate
each
patient.
Pediatric Pulmonology,
Journal Year:
2021,
Volume and Issue:
56(10), P. 3166 - 3173
Published: July 21, 2021
The
COVID-19
pandemic
has
had
a
profound
impact
on
healthcare
access
and
utilization,
which
could
have
important
implications
for
children
with
chronic
diseases,
including
asthma.
We
sought
to
evaluate
changes
in
utilization
outcomes
asthma
during
the
pandemic.
used
electronic
health
records
data
use
3959
adolescents,
5-17
years
of
age,
prior
diagnosis
who
history
well-child
visits
encounters
within
system.
assessed
all-cause
exacerbations
12-months
preceding
start
(March
1,
2019-February
29,
2020)
first
12
months
2020-February
28,
2021).
All-cause
decreased
significantly
compared
year,
(48.1%
vs.
66.6%
year;
p
<
.01),
emergency
department
(9.7%
21.0%;
inpatient
admissions
(1.6%
2.5%;
though
there
was
over
100-fold
increase
telehealth
encounters.
Asthma
that
required
treatment
systemic
steroids
also
(127
504
exacerbations;
.01).
Race/ethnicity
not
associated
or
outcomes.
corresponded
dramatic
shifts
increased
improved
among
Social
distancing
measures
may
reduced
trigger
exposure.
Pediatric Pulmonology,
Journal Year:
2021,
Volume and Issue:
57(1), P. 20 - 25
Published: Oct. 21, 2021
Abstract
Background
With
the
onset
of
coronavirus
disease
2019
(COVID‐19)
pandemic,
many
experts
expected
that
asthma‐associated
morbidity
because
severe
acute
respiratory
syndrome
2
infection
would
dramatically
increase.
However,
some
studies
suggested
there
was
no
apparent
increasing
in
asthma‐related
children
with
asthma,
it
is
even
possible
may
have
improved
outcomes.
To
understand
relationship
between
COVID‐19
pandemic
and
asthma
outcomes,
we
performed
this
article.
Methods
We
searched
PubMed,
Embase,
Cochrane
Library
to
find
literature
from
December
June
2021
related
children's
control,
among
which
results
such
as
abstracts,
comments,
letters,
reviews,
case
reports
were
excluded.
The
level
control
during
synthesized
discussed
by
outcomes
exacerbation,
emergency
room
visit,
admission,
childhood
test
(c‐ACT).
Results
A
total
22,159
subjects
included
10
studies.
Random
effect
model
used
account
for
data.
Compared
same
period
before
exacerbation
reduced
(odds
ratio
[OR]
=
0.26,
95%
confidence
interval
[CI]
[0.14–0.48],
Z
4.32,
p
<
0.0001),
odds
visit
decreased
well
(OR
0.11,
CI
[0.04–0.26],
4.98,
0.00001).
outcome
admission
showed
significant
difference
0.84,
[0.32–2.20],
0.36,
0.72).
c‐ACT
scores
not
analyzed
different
manifestations
used.
Overall,
pandemic.
Conclusion
has
been
significantly
improved.
need
exact
factors
leading
these
improvements
methods
sustain
it.
The Lancet Regional Health - Europe,
Journal Year:
2022,
Volume and Issue:
19, P. 100428 - 100428
Published: June 16, 2022
Several
countries
reported
a
substantial
reduction
in
asthma
exacerbations
associated
with
COVID-19
pandemic-related
restrictions.
However,
it
is
not
known
if
these
early
declines
were
short-term
and
have
rebounded
to
pre-pandemic
levels
following
easing
of
lockdown
Allergy,
Journal Year:
2022,
Volume and Issue:
78(6), P. 1665 - 1670
Published: Nov. 28, 2022
The
impact
of
coronavirus
disease
2019
(COVID-19)
on
allergic
diseases
in
adolescents
is
not
well
described.
Although
there
have
been
previous
studies
that
examined
changes
prevalence
1
year
into
the
pandemic,
a
need
for
follow-up
due
to
nature
infectious
disease.1
Therefore,
this
article
will
examine
among
Korean
before
and
during
COVID-19
from
2009
2021.
data
were
accessed
Korea
Youth
Risk
Behavior
Web-based
Survey
(KYRBS)
KYRBS
self-reported
online
survey
monitors
health-related
behaviors
contribute
leading
cause
death
disability
young
adults.
employs
sample
selection
methods
such
as
stratified
cluster
sampling
so
thoroughly
reflects
entire
population.2
period
pandemic
(2009–2019)
was
divided
intervals
two
or
three
consecutive
years,
while
each
(2020–2021)
individually.
They
manner
obtain
stable
estimates
prevalence.
Cases
asthma,
rhinitis,
atopic
dermatitis
included
basis
having
diagnosed
within
past
12
months.
Allergic
morbidity
defined
at
least
one
conditions
mentioned
above.3
study
protocol
approved
by
institutional
review
boards
Sejong
University
(SJU-HR-E-2020-003)
Disease
Control
Prevention
Agency.
against
covariates
age,
sex,
BMI,
residence
area,
smoking
status,
alcohol
consumption,
parents'
educational
level,
economic
school
performance.
This
measured
through
weighted
complex
analysis
using
linear
binary
logistic
regression
models
which
enabled
us
quantitatively
grasp
extent
change
between
period.
SAS
version
9.4
(SAS
Institute)
SPSS
26.0
(IBM)
used
perform
all
statistical
analyses.
bold
numbers
indicate
significant
difference
two-sided
p-value
less
than
0.05.
There
total
840,488
aged
12–18,
with
52.30
percent
male
mean
age
15.08
years
(Table
S1).
increased
23.19%
(95%
CI,
22.93–23.45)
2011
25.09%
24.76–25.42)
2018
2019.
However,
pronounced
decrease
after
outbreak
(βdiff
−0.095,
95%
CI
−0.145
−0.085;
odds
ratio
[OR]
0.799,
0.779–0.820).
asthma
gradually
decreased
2.23%
2.15–2.31)
1.99%
1.90–2.09)
2019,
then
rapidly
−0.137,
−0.288
−0.110;
OR
0.495,
0.456–0.538).
rhinitis
17.79%
17.54–18.04)
20.45%
20.14–20.76)
it
−0.119,
−0.1698
−0.108;
0.795,
0.772–0.818).
Similarly,
remained
similar,
slightly
6.74%
6.61–6.87)
6.82
6.65–6.99)
−0.030,
-0.045
−0.016;
0.927,
0.892–0.962).
It
observed
female
overweight
obese
subgroups
are
relatively
more
vulnerable
Figure
1).
Also,
reduction
modest
compared
others
because
aeroallergen
main
etiology.
These
results
suggest
some
exceptions
S2).
could
be
interpreted
result
pandemic.
South
announced
first
case
January
2020,
number
confirmed
cases
20
following
month
social
gatherings.
Since,
government
has
implemented
strict
public
health
measures
order
prevent
mitigate
transmission
virus.4,
5
For
example,
business
hour
restrictions,
self-isolation
measures,
distancing
guidelines,
mask
mandates,
nationwide
lockdowns,
closures,
vaccination
recommendations.4,
acted
physical
barriers
environmental
interactions
blocked
direct
and/or
indirect
contact
penetration
allergens,
hence
decreasing
diseases.
consistent
other
Brazil,
India,
Singapore
demonstrated
sustained
admissions
widespread
measures.1,
6
they
utilize
small
heterozygous
samples
only
strength
lies
utilization
almost
million
adolescents.
Nevertheless,
several
limitations
should
taken
account.
First,
excluded
those
who
enrolled
education
system.
Second,
potential
underdiagnosis
reluctance
visit
hospital.7
Third,
hard
estimate
exact
quantity
influence
risk
factor
mental
health.
Finally,
although
questionnaire-based
assessments
our
reliable
(kappa
coefficient:
0.48–0.80),8
objective
measurements
pulmonary
function
tests
advised
verify
severity
disease.
overall
displayed
continuous
increase
followed
minute
(2020–2021).
In
light
findings,
we
would
like
encourage
continued
efforts
monitor
come,
even
over.
understanding
provide
useful
information
establishing
future
policies
response
new
wave
also
recommended
conduct
research
infection
status
types
Word
Count:
835.
authors
thank
Stella
Ting
(Department
English,
Toronto,
Ontario,
Canada)
proofreading
manuscript.
supported
grant
Health
Technology
R&D
Project,
Industry
Development
Institute
(KHIDI),
funded
Ministry
&
Welfare,
Republic
(grant
number:
HV22C0233)
National
Research
Foundation
(NRF)
(MSIT;
NRF-2020R1C1C1005293).
funders
had
no
role
design,
collection,
analysis,
interpretation,
writing
report.
Dr
Katrina
Abuabara
consultant
TARGET
RWE.
Other
declare
conflicts
interest.
Appendix
S1
Please
note:
publisher
responsible
content
functionality
any
supporting
supplied
authors.
Any
queries
(other
missing
content)
directed
corresponding
author
article.
International Immunology,
Journal Year:
2021,
Volume and Issue:
34(4), P. 177 - 188
Published: Nov. 10, 2021
The
coronavirus
disease
2019
(COVID-19)
pandemic
causes
an
overwhelming
number
of
hospitalization
and
deaths
with
a
significant
socioeconomic
impact.
vast
majority
studies
indicate
that
asthma
allergic
diseases
do
not
represent
risk
factor
for
COVID-19
susceptibility
nor
cause
more
severe
course
disease.
This
raises
the
opportunity
to
investigate
underlying
mechanisms
interaction
between
background
acute
respiratory
syndrome
2
(SARS-CoV-2)
infection.
patients
asthma,
atopic
dermatitis,
rhinitis,
chronic
rhinosinusitis,
food
allergies
drug
exhibit
over-expression
type
immune
inflammatory
pathways
contribution
epithelial
cells,
innate
lymphoid
dendritic
T
eosinophils,
mast
basophils,
cytokines
interleukin
(IL)-4,
IL-5,
IL-9,
IL-13,
IL-31.
potential
impact
inflammation-related
on
severity
its
have
been
reported.
In
this
review,
prevalence
other
common
in
is
addressed.
Moreover,
non-allergic
different
control
status,
currently
available
treatments
such
as
inhaled
oral
corticosteroids,
short-
long-acting
β2
agonists,
leukotriene
receptor
antagonists
biologicals
outcome
reviewed.
addition,
possible
protective
inflammation
infection,
expression
SARS-CoV-2
entry
receptors,
antiviral
activity
eosinophils
cross-reactive
T-cell
epitopes,
are
discussed.
Potential
interactions
postulated,
including
recommendations
their
management.
The Journal of Allergy and Clinical Immunology In Practice,
Journal Year:
2021,
Volume and Issue:
10(1), P. 91 - 99.e12
Published: Nov. 14, 2021
Respiratory
viruses,
air
pollutants,
and
aeroallergens
are
all
implicated
in
worsening
pediatric
asthma
symptoms,
but
their
relative
contributions
to
exacerbations
poorly
understood.
A
significant
decrease
has
been
observed
during
the
coronavirus
disease
2019
pandemic,
providing
a
unique
opportunity
study
how
major
triggers
correlate
with
activity.To
determine
whether
changes
respiratory
and/or
pandemic
were
concomitant
decreased
exacerbations.Health
care
utilization
viral
testing
data
between
January
1,
2015,
December
31,
2020,
extracted
from
Children's
Hospital
of
Philadelphia
Care
Network's
electronic
health
record.
Air
pollution
allergen
US
Environmental
Protection
Agency
public
databases
National
Allergy
Bureau-certified
station,
respectively.
Pandemic
(2020)
compared
historical
data.Recovery
in-person
encounters
phased
reopening
(June
6
November
15,
2020)
was
uneven:
primary
well
specialty
reached
94%
74%
prepandemic
levels,
respectively,
whereas
sick
hospital
21%
40%
During
influenza
B
negligible
frequency
when
cases,
syncytial
virus
rhinovirus
infections
low
(though
nonnegligible)
as
well.
No
or
aeroallergen
levels
observations
noted.Our
results
suggest
that
driver
exacerbations.
These
findings
have
broad
relevance
both
clinical
practice
development
policies
aimed
at
reducing
morbidity.
JAMA Network Open,
Journal Year:
2022,
Volume and Issue:
5(3), P. e222933 - e222933
Published: March 17, 2022
Importance
The
association
of
the
COVID-19
pandemic
with
quality
ambulatory
care
is
unknown.
Hospitalizations
for
care–sensitive
conditions
(ACSCs)
are
a
well-studied
measure
care;
however,
they
may
also
be
associated
other
patient-level
and
system-level
factors.
Objective
To
describe
trends
in
hospital
admissions
ACSCs
prepandemic
period
(March
2019
to
February
2020)
compared
2020
2021).
Design,
Setting,
Participants
This
cross-sectional
study
adults
enrolled
commercial
health
maintenance
organization
Michigan
included
1
240
409
unique
(13
011
176
person-months)
206
361
(12
759
675
period.
Exposure
Main
Outcomes
Measures
Adjusted
relative
risk
(aRR)
ACSC
hospitalizations
intensive
unit
stays
adjusted
incidence
rate
ratio
length
stay
vs
2021)
periods,
patient
age,
sex,
calendar
month
admission,
county
residence.
Results
population
period,
which
51.3%
person-months
(n
=
6
547
231)
were
female
patients,
relatively
even
age
distribution
between
ages
24
64
years.
having
any
hospitalization
was
0.72
(95%
CI,
0.69-0.76;P
<
.001).
decrease
slightly
larger
magnitude
than
overall
reduction
non-ACSC,
non–COVID-19
rates
(aRR,
0.82;
95%
0.81-0.83;P
Large
reductions
found
respiratory-related
0.54;
0.50-0.58;P
.001),
non–statistically
significant
diabetes-related
0.91;
0.83-1.00;P
.05)
statistically
all
0.79;
0.74-0.85;P
Among
hospitalizations,
no
change
percentage
that
an
0.99;
0.94-1.04;P
.64),
(adjusted
ratio,
1.02;
0.98-1.06;P
.33).
Conclusions
Relevance
In
this
large
plan,
both
non-ACSC
particularly
seen
ACSCs.
These
likely
due
many
system–level
factors
rates.
Further
research
into
causes
long-term
outcomes
these
needed
understand
how
has
affected
delivery
US.