Food allergy across the globe

Journal of Allergy and Clinical Immunology, Journal Year: 2021, Volume and Issue: 148(6), P. 1347 - 1364

Published: Dec. 1, 2021

Language: Английский

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Skin as the target for allergy prevention and treatment

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(2), P. 133 - 143

Published: Jan. 21, 2024

Language: Английский

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Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

Allergy, Journal Year: 2022, Volume and Issue: 77(10), P. 2937 - 2948

Published: June 22, 2022

The incidence of food allergy (FA) has continued to rise over the last several decades, posing significant burdens on health and quality life. Significant strides into advancement FA diagnosis, prevention, treatment have been made in recent years. In an effort lower reliance resource-intensive challenges, field work toward development highly sensitive specific assays capable high-throughput analysis assist diagnosis FA. looking early infancy as a critical period or acquisition tolerance, evidence increasingly suggested that intervention via introduction allergens maintenance skin barrier function may decrease risk As such, large-scale investigations are underway evaluating infant feeding impact emollient steroid use infants with dry for prevention allergy. On other end spectrum, past few years witness explosive increase clinical trials novel innovative therapeutic strategies aimed at those whom disease already manifested. A milestone field, 2020 marked approval first drug, oral peanut allergen, indication With foundation promising data supporting safety efficacy single- multi-allergen immunotherapy, current efforts turned probiotics, biologic agents, modified optimize improve upon existing paradigms. Through these advancements, hopes gain footing ongoing battle against

Language: Английский

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Epidemiology of Paediatric Italian Food Allergy: Results of the EPIFA study

Journal of Allergy and Clinical Immunology Global, Journal Year: 2024, Volume and Issue: 3(3), P. 100246 - 100246

Published: March 26, 2024

Updated epidemiologic data are important for defining effective public health strategies pediatric food allergy (FA).

Language: Английский

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Early Introduction of Allergenic Foods and the Prevention of Food Allergy

Nutrients, Journal Year: 2022, Volume and Issue: 14(13), P. 2565 - 2565

Published: June 21, 2022

The increasing prevalence of food allergies is a growing public health problem. For children considered high risk developing allergy (particularly due to the presence other or severe eczema), evidence for early introduction allergenic foods, and in particular peanut egg, robust. In such cases, consensus clear that not only should foods be delayed, but they introduced at approximately 4 6 months age order minimize development. appears an effective strategy minimizing burden allergy, though further studies on generalizability this approach low-risk populations needed.

Language: Английский

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Early, continuing exposure to cow's milk formula and cow's milk allergy

Annals of Allergy Asthma & Immunology, Journal Year: 2022, Volume and Issue: 130(2), P. 233 - 239.e4

Published: Oct. 28, 2022

Language: Английский

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How dietary advanced glycation end products could facilitate the occurrence of food allergy

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 153(3), P. 742 - 758

Published: Nov. 30, 2023

BackgroundFood allergy (FA) is one of the most common chronic conditions in children with an increasing prevalence facilitated by exposure to environmental factors predisposed individuals. It has been hypothesized that increased consumption ultra-processed foods, containing high levels dietary advanced glycation end products (AGEs), could facilitate occurrence FA.ObjectiveWe sought provide preclinical and clinical evidence on potential role AGEs facilitating FA.MethodsHuman enterocytes, human small intestine organ culture, PBMCs from at risk for were used investigate direct effect gut barrier, inflammation, TH2 cytokine response, mitochondrial function. Intake 3 Western diet Nε-(carboxymethyl) lysine, Nε-(1-carboxyethyl) lysin, Nδ-(5-hydro-5- methyl-4-imidazolone-2-yl)-ornithine (MG-H1), accumulation skin comparatively investigated FA age-matched healthy controls.ResultsHuman enterocytes exposed showed alteration AGE receptor expression, reactive oxygen species production, autophagy, transepithelial passage food antigens. Small cultures increase CD25+ cells proliferating crypt enterocytes. proliferation rate, activation, release inflammatory cytokines, metabolism. Significant higher intake observed (n = 42) compared controls 66).ConclusionsThese data, supporting a FA, suggest importance limiting as preventive strategy against this condition. Food FA. We Human controls. 66). These

Language: Английский

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Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair—Facts and Challenges

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1070 - 1070

Published: Feb. 21, 2023

Food allergy represents a growing public health and socio-economic problem with an increasing prevalence over the last two decades. Despite its substantial impact on quality of life, current treatment options for food are limited to strict allergen avoidance emergency management, creating urgent need effective preventive strategies. Advances in understanding pathogenesis allow develop more precise approaches targeting specific pathophysiological pathways. Recently, skin has become important target prevention strategies, as it been hypothesized that exposure through impaired barrier might induce immune response resulting subsequent development allergy. This review aims discuss evidence supporting this complex interplay between dysfunction by highlighting crucial role epicutaneous sensitization causality pathway leading progression clinical We also summarize recently studied prophylactic therapeutic interventions repair emerging strategy controversies future challenges. Further studies needed before these promising strategies can be routinely implemented advice general population.

Language: Английский

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Efficacy of probiotics in pediatric atopic dermatitis: A systematic review and meta‐analysis

Clinical and Translational Allergy, Journal Year: 2023, Volume and Issue: 13(7)

Published: July 1, 2023

Atopic dermatitis (AD) is a prevailing skin disease in childhood. Several studies have appraised probiotics as strategy for treating AD. We aimed to assess the validity of treatment AD children.

Language: Английский

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Early‐life risk factors for food allergy: Dietary and environmental factors revisited

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2023, Volume and Issue: 22(6), P. 4355 - 4377

Published: Sept. 7, 2023

Abstract There appears a steep increase in the prevalence of food allergy worldwide past few decades. It is believed that, rather than genetic factors, recently altered dietary and environmental factors are driving forces behind rapid this disease. Accumulating evidence has implied that external exposures occurred prenatal postnatal periods could affect development oral tolerance later life. Understanding potential risk for would greatly benefit progress intervention therapy. In review, we present updated knowledge on early life have been shown to impact allergy. These predominantly include habits, microbial exposures, allergen exposure routes, pollutants, so on. The key evidence, conflicts, research topics each theory discussed, associated interventional strategies prevent disease ameliorate treatment burden included. supported causative role certain establishment life, especially time introducing allergenic foods, skin barrier function, exposures. addition immunomodulatory increasing interest raised toward modern patterns, where adequately powered studies required identify contributions those modifiable factors. This review broadens our understanding connections between diet, environment, early‐life immunity, thus benefiting therapy

Language: Английский

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