The Natural History and Risk Factors for the Development of Food Allergies in Children and Adults

Current Allergy and Asthma Reports, Journal Year: 2024, Volume and Issue: 24(3), P. 121 - 131

Published: Feb. 28, 2024

Abstract Purpose of Review This narrative review explores food allergy prevalence and natural history stratified by life stages, especially in context evolving knowledge over the last few decades. Recent Findings The remains highest early childhood with common triggers being cow’s milk, soy, hen’s egg, wheat, peanut, tree nuts, sesame, fish, shellfish. correlates certain risk factors pertinent postnatal period which appear to predispose an individual developing a allergy. Some allergies (such as milk egg) were previously thought be easily outgrown life; however, recent studies suggest increasing rates persistence these into young adulthood; reason behind this is unknown. Despite this, there also evidence demonstrating that can adolescents adults. Summary An understanding paradigm shifts allows clinicians provide updated, age-appropriate, tailored advice for patients on management prognosis

Language: Английский

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Diversity of complementary diet and early food allergy risk

Pediatric Allergy and Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 1, 2025

Abstract Introduction Diet diversity (DD) in infancy may be protective for early food allergy (FA) but there is limited knowledge about how DD incorporating consumption frequency influences FA risk. Methods Three measures of were investigated 2060 infants at 6 and/or 9 months age within the NorthPop Birth Cohort Study: a weighted score based on intake frequency, number introduced foods, and allergenic foods. In multivariable logistic regression models directed acyclic graphs, associations to parentally reported physician‐diagnosed 18 estimated, including sensitivity stratified analyses. Results High scores (24‐31p) associated with 61% decreased odds [OR (95% CI) = 0.39 0.18–0.88] compared lowest (0‐17p). The association remained significant after exclusion cases. Having 13–14 foods months, independent was 45% 0.55 (0.31–0.98)] having 0–10 When stratifying, significantly reduced seen children eczema no history family. No between months. Conclusion A diverse diet prevent Our results underscore need additional investigations impact infancy.

Language: Английский

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Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair—Facts and Challenges

Nutrients, Journal Year: 2023, Volume and Issue: 15(5), P. 1070 - 1070

Published: Feb. 21, 2023

Food allergy represents a growing public health and socio-economic problem with an increasing prevalence over the last two decades. Despite its substantial impact on quality of life, current treatment options for food are limited to strict allergen avoidance emergency management, creating urgent need effective preventive strategies. Advances in understanding pathogenesis allow develop more precise approaches targeting specific pathophysiological pathways. Recently, skin has become important target prevention strategies, as it been hypothesized that exposure through impaired barrier might induce immune response resulting subsequent development allergy. This review aims discuss evidence supporting this complex interplay between dysfunction by highlighting crucial role epicutaneous sensitization causality pathway leading progression clinical We also summarize recently studied prophylactic therapeutic interventions repair emerging strategy controversies future challenges. Further studies needed before these promising strategies can be routinely implemented advice general population.

Language: Английский

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Nasal food challenge with hen's egg white allergen

Allergy Asthma and Clinical Immunology, Journal Year: 2025, Volume and Issue: 21(1)

Published: Jan. 12, 2025

Nasal allergen provocation tests are an important part of the diagnostics allergic diseases triggered by environmental factors. Recently, increased attention has been paid to potential use this method in diagnosis food allergy. The objective study was evaluate usefulness nasal test a group subjects hen's egg white allergens. material consisted 57 (32 with allergy and 25 healthy controls). carried out assessed using visual analog scale optical rhinometry as well determination sIgE tryptase levels lavage fluid. Subjective symptoms evaluations following application 100 µg revealed moderately positive mucosal response (ΔE = 0.34 OD). challenge is good diagnostic alternative patients. Due insufficient number studies so far, further attempts at standardization required.

Language: Английский

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Food allergen introduction practices and parent/caregiver attitudes based on family history of food allergy

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 6

Published: March 19, 2025

Background The National Institute of Allergy and Infectious Disease (NIAID) addendum guidelines for primary prevention peanut allergy1 provide recommendations regarding introduction, a recent consensus statement highlighted the importance timely introduction other commonly allergenic solids, role family history as risk factor.2ObjectiveTo determine whether children in households with food allergic parent/caregiver or sibling have different rates being fed solids during first year life than lacking this history. Methods A pretested survey was administered between January-February 2021 to U.S. sample 3,062 parents/caregivers born since NIAID Addendum guidelines. Survey-weighted chi-square statistics logistic regression models tested independence key variables across strata interest before after covariate adjustment. Results Peanut, almond, shellfish, tree nuts are more likely be introduced one food-allergic caregivers. Respondents parents (39.3%) siblings FA (35.8%) were familiar 2017 compared (12.9%) without (12.7%). Conclusion Findings suggest that respondents many most prevalent allergens at younger ages, which could due knowledge related NIAID-sponsored national guidance, but even among these higher-risk families overall “early” infancy still remain relatively low.

Language: Английский

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Health disparities in food allergy

Current problems in pediatric and adolescent health care, Journal Year: 2025, Volume and Issue: unknown, P. 101731 - 101731

Published: April 1, 2025

Language: Английский

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Suppressive effect of black tea polyphenol theaflavins in a mouse model of ovalbumin-induced food allergy

Journal of Natural Medicines, Journal Year: 2023, Volume and Issue: 77(3), P. 604 - 609

Published: March 1, 2023

Language: Английский

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Current state and advances in desensitization for peanut allergy in pediatric age

Pediatric Allergy and Immunology, Journal Year: 2024, Volume and Issue: 35(4)

Published: April 1, 2024

Abstract Peanut allergy affects about 1%–3% of the pediatric population in world, with an important increase last decades. Nowadays, international guidelines recommend early introduction peanuts infant diet, poor information quantity and frequency intake. Allergen immunotherapy may represent only therapeutic strategy able to modify natural history peanut allergy. In particular, oral showed most promising results terms efficacy, but significant rates adverse reactions, mostly gastrointestinal. 2020, Food Drug Administration European Medicines Agency approved Palforzia®, drug for patients aged 4–17 years. Several studies are ongoing improve tolerability standardize desensitization protocols. Sublingual permits offer much lower doses than immunotherapy, fewer events shown. Subcutaneous is associated greatest systemic effects. Epicutaneous which Viaskin® patch was approved, has highest safety profile. Innovative evaluating use biological drugs, such as omalizumab or dupilumab, probiotics, Lactobacillus rhamnosus , monotherapy immunotherapy. Therapy constantly evolving, new perspectives develop. image

Language: Английский

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Complementary Feeding Practices: Recommendations of Pediatricians for Infants with and without Allergy Risk

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 239 - 239

Published: Jan. 12, 2024

Aim: To investigate the routine guidance provided by pediatricians concerning timing of complementary feeding (CF) for both healthy infants and those at a heightened risk allergies. Methods: A total 233 participated in an anonymous online survey that included questions about demographics recommendations CF. Specifically, they on types foods, preparation methods, supplements, time intervals introducing new foods to low high allergy risk, delayed food introductions high-risk cases. Results: The respondents advised certain specific ages: fruits, starchy non-gluten grains, vegetables, olive oil, meat were appropriate 6 months; gluten-rich grains 7 yogurt, hard-boiled eggs, legumes 8 fish 8.5 nuts 9 months. Pediatricians, especially with less than 15 years practice, often introduced egg, seafood, legumes, earlier infants. Parenthood male gender associated introduction eggs grains. Conclusions: Greek follow structured schedule CF Interestingly, tend delay common allergens recommend longer between particularly Key Notes: Despite recent evidence-based indications strategies infants, discrepancies persist among regarding choices order introduction, allergy. Guidance is influenced their individual characteristics. Pediatricians

Language: Английский

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Decoding food reactions: a detailed exploration of food allergies vs. intolerances and sensitivities

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 45

Published: May 15, 2024

The food matrix is a complex system encompassing all constituent elements in production. It influences the digestibility of these through direct interactions and affects digestive environment. Furthermore, gastrointestinal possesses precise mechanisms that efficiently process dietary components into essential nutrients, effectively preventing onset abnormal immune responses or dysfunctional host reactions most instances. However, incidence adverse constantly increasing, evidence indicates this environmental. Adverse can be categorized as toxic nontoxic. Toxic are dose-dependent result from natural compounds, processing-induced substances, contaminants. Nontoxic like intolerance hypersensitivity depend on individual susceptibility evoke specific pathological physiological responses. This review aims to elucidate underlying occurrence immune- (food allergies sensitivities) non-immune-mediated intolerance) reactions, emphasizing fundamental distinctions between two categories. Enhanced comprehension distinction will significantly contribute advancing preventive therapeutic approaches establishing guidelines for labeling concerning immune-mediated reactions.

Language: Английский

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