Pediatric Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Language: Английский
Journal of the American Academy of Dermatology, Journal Year: 2024, Volume and Issue: unknown
Published: June 1, 2024
Language: Английский
Citations
9
Cells, Journal Year: 2023, Volume and Issue: 12(24), P. 2793 - 2793
Published: Dec. 8, 2023
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and presents a major public health problem worldwide. It characterized by recurrent and/or course of lesions with intense pruritus. Its pathophysiologic features include barrier dysfunction, aberrant immune cell infiltration, alterations in microbiome that are associated genetic environmental factors. There complex crosstalk between these components, which primarily mediated cytokines. Epidermal dysfunction hallmark AD caused disruption proteins lipids responsible for establishing barrier. To better define role cytokines stratum corneum lipid abnormalities related to AD, we conducted systematic review biomedical literature PubMed from its inception 5 September 2023. Consistent dominant TH2 skewness seen type 2 were featured prominently as possessing central epidermal skin. The TH1 TH17 also identified affect lipids. Considering broad cytokine dysregulation observed pathophysiology, understanding each will help developing therapeutics best achieve homeostasis patients.
Language: Английский
Citations
20
Allergy, Journal Year: 2023, Volume and Issue: 78(8), P. 2290 - 2300
Published: April 10, 2023
Abstract Background Atopic dermatitis (AD) patients display an altered skin microbiome which may not only be indicator but also a driver of inflammation. We aimed to investigate associations among AD patients' microbiome, clinical data, and response systemic therapy in the TREATgermany registry. Methods Skin swabs 157 were profiled with 16S rRNA gene amplicon sequencing before after 3 months treatment dupilumab or cyclosporine. For comparison, 16s data from 258 population‐based healthy controls used. Disease severity was assessed using established instruments such as Eczema Area Severity Index (EASI). Results confirmed previously shown correlation Staphylococcus aureus abundance bacterial alpha diversity measured by EASI. Therapy Dupilumab shifted community toward pattern seen controls. The relative Staphylococci particular S. significantly decreased on both lesional non‐lesional skin, whereas hominis increased. These changes largely independent degree improvement observed for Conclusions Systemic cyclosporine tends restore indicating potential effects IL‐4RA blockade microbiome.
Language: Английский
Citations
19
Asia Pacific Allergy, Journal Year: 2023, Volume and Issue: unknown
Published: March 31, 2023
It is now longer than half a century, humans, animals, and nature of the world are under influence exposure to many newly introduced noxious substances. These exposures nowadays pushing borders be considered as causative or exacerbating factors for chronic disorders including allergic, autoimmune/inflammatory, metabolic diseases. The epithelial linings serve outermost body’s primary physical, chemical, immunological barriers against external stimuli. “epithelial barrier theory” hypothesizes that these diseases aggravated by an ongoing periepithelial inflammation triggered wide range barrier–damaging insults lead “epithelitis” release alarmins. A leaky enables microbiome’s translocation from periphery interepithelial even deeper subepithelial areas together with allergens, toxins, pollutants. Thereafter, microbial dysbiosis, characterized colonization opportunistic pathogen bacteria loss number biodiversity commensal take place. Local inflammation, impaired tissue regeneration, remodeling characterize disease. infiltration inflammatory cells affected tissues shows effort expulse invading bacteria, pollutants away deep surface, representing “expulsion response.” Cells migrate other organs foci may play roles in exacerbation various distant organs. purpose this review highlight appraise recent opinions findings on physiology its role pathogenesis view theory.
Language: Английский
Citations
18
Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 153(5), P. 1456 - 1463.e4
Published: March 3, 2024
Language: Английский
Citations
8
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 941 - 951
Published: March 1, 2024
Abstract: Atopic dermatitis (AD), a common pruritic and chronic inflammatory skin disease, has major impact on patient's quality of life. It is characterized by dry, itchy, eczema-like rashes. AD more prevalent in young children been linked to variety other allergy disorders. Traditional drug therapy certain limitations for treating with AD. However, biologics have good clinical application prospects the medical treatment patients. Dupilumab, fully human monoclonal antibody, specifically binds IL-4 Rα subunit, inhibiting IL-13 signaling blocking occurrence type 2 response. effect infants moderate-to-severe This review explores safety efficacy dupilumab early intervention progression, aim informing practice use patients Keywords: atopic dermatitis, dupilumab, infant, child,
Language: Английский
Citations
7
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 277 - 289
Published: Feb. 1, 2024
Abstract: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Children with severe AD have a multidimensional burden characterized by lesions, itching, frequent infections, sleep deprivation, and high rate of comorbidities. These impact mental health overall quality life not only children but also their parents caregivers. There are few effective available treatment options for young that suitable long-term use. Due to adverse effects, practice guidelines consider systemic agents inappropriate this age group, although they still used off-label extreme cases. The biologic dupilumab has recently been approved aged 6– 11 years (EU) moderate-to-severe (USA) AD, offering hope population patients unmet clinical need. purpose review describe needs prior approval summarize existing data supporting dupilumab's safety efficacy these Keywords: atopic dermatitis, children, dupilumab, pediatric,
Language: Английский
Citations
6
Allergy, Journal Year: 2024, Volume and Issue: 79(10), P. 2605 - 2624
Published: Aug. 4, 2024
Abstract The 4th Davos Declaration was developed during the Global Allergy Forum in which aimed to elevate care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. forum addressed high prevalence AD, a strategic focus on advancing research, treatment, management meet evolving challenges field. This multidisciplinary brought together top leaders from clinical practice, policy, patient advocacy discuss critical aspects including neuroimmunology, environmental factors, comorbidities, breakthroughs prevention, diagnosis, treatment. discussions were geared towards fostering collaborative approach integrate these advancements into practical, patient‐centric care. underlined mounting burden attributing it significant lifestyle changes. It acknowledged progress understanding AD developing targeted therapies but recognized gap translating innovations practice. Emphasis placed need for enhanced awareness, education, stakeholder engagement address this effectively consider factors comprehensive disease strategy. marks milestone journey improve people AD. By promoting holistic that combines application, sets roadmap stakeholders collaborate outcomes reflecting commitment adapt respond dynamic changing world.
Language: Английский
Citations
5
Experimental Dermatology, Journal Year: 2023, Volume and Issue: 33(1)
Published: Nov. 16, 2023
Seborrheic dermatitis (SD) is a chronic inflammatory skin disease characterized by erythematous papulosquamous lesions in sebum rich areas such as the face and scalp. Its pathogenesis appears multifactorial with disbalanced immune system, Malassezia driven microbial involvement barrier perturbations. Microbial has been well described SD, but remains to be properly elucidated. To determine whether impairment critical factor of inflammation SD alongside dysbiosis, cross-sectional study was performed 37 patients mild-to-moderate facial SD. Their lesional non-lesional comprehensively non-invasively assessed standardized 2D-photography, optical coherence tomography (OCT), profiling including species identification, functional assessments ceramide profiling. The presence established through significant increases erythema, epidermal thickness, vascularization superficial roughness compared skin. Lesional showed perturbed an underlying skewed subclass composition, impaired chain elongation increased unsaturation. Changes composition correlated indicating interdependency composition. significantly Staphylococcus decreased Cutibacterium abundances similar mycobial Principal component analysis highlighted properties main discriminating features. conclude, associated dysfunction changes No differences abundance were observed. Restoring cutaneous might valid therapeutic approach treatment
Language: Английский
Citations
12
The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2023, Volume and Issue: 11(5), P. 1421 - 1428
Published: March 22, 2023
Language: Английский
Citations
11