American Journal of Men s Health,
Journal Year:
2024,
Volume and Issue:
18(6)
Published: Nov. 1, 2024
Guijiajiao-Lujiaojiao
(GL)
is
a
combination
of
Traditional
Chinese
Medicine
(TCM)
that
can
be
used
to
treat
oligoasthenozoospermia
(OAS).
However,
its
mechanistic
role
in
OAS
needs
better
understood
and
necessitates
more
studies.
This
study
was
planned
investigate
GL's
therapeutic
effects
the
tripterygium
wilfordii
polyglycoside
(GTW)-induced
rat
model.
In
total,
60
Sprague-Dawley
(SD)
rats
at
8
weeks
age
were
assigned
six
groups:
blank
(NC),
model
(GTW),
GL
low-dose
(GL-L,
0.3
g/kg/day),
medium-dose
(GL-M,
0.6
high-dose
(GL-H,
1.2
+
PI3K
inhibitor
LY294002
(GL-H
g/kg/day
LY
mg/kg/day)
groups.
The
characterized
after
examine
sperm
concentration
viability,
serum
hormone
levels,
testes
histopathology,
specific
protein
markers.
treatment
efficacy
evaluated
by
mRNA
expression
among
other
parameters.
Compared
with
GTW
group,
viability
spermatozoa
significantly
increased
intervention
(
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 18, 2024
Impaired
spermatogenesis
and
male
infertility
are
common
consequences
of
chemotherapy
drugs
used
in
patients
with
testicular
cancer.
The
present
study
investigated
the
effects
sodium
alginate
(NaAL)
on
toxicity
caused
by
bleomycin,
etoposide,
cisplatin
(BEP).
Rats
group
1
received
normal
saline,
while
groups
2
3
were
treated
25
50
mg/kg
NaAL,
respectively.
Group
4
was
a
21-day
cycle
BEP
(0.5
5
cisplatin),
6
regimen
plus
Then,
sperm
parameters,
testosterone
levels,
histopathology
stereological
levels
malondialdehyde
(MDA),
nitric
oxide
(NO),
total
antioxidant
capacity
(TAC),
expression
apoptosis-associated
genes
including
Bcl2,
Bax,
Caspase3,
p53,
TNF-α
evaluated.
Our
findings
revealed
that
NaAL
improved
histopathology,
stereology
parameters
BEP-administrated
rats.
also
testis
status
enhancing
TAC
ameliorating
MDA
NO.
Further,
modifications
to
suggested
alleviated
BEP-induced
apoptosis
inflammation.
Collectively,
protects
rats'
testes
against
BEP-evoked
damage
through
modulation
nitro-oxidative
stress,
apoptosis,
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
163, P. 114810 - 114810
Published: May 8, 2023
Garlic
(Allium
sativum
L.)
is
a
primary
dietary
component
worldwide
because
of
its
health
benefits
and
use
as
traditional
medicine.
Elephant
garlic
ampeloprasum
L.),
related
species
in
the
same
genus,
less
intense
sweeter
than
A.
sativum.
The
object
this
study
was
to
investigate
alleviative
effects
aged
black
(ABG)
elephant
(ABEG)
on
obesity
muscle
atrophy
induced
by
high
fat
diet-induced
obese
mice.
We
demonstrated
that
ABG
ABEG
alleviated
enhanced
myogenic
differentiation
myotube
hypertrophy,
effect
mediated
upregulation
Akt/mTOR/p70S6K
signaling.
Furthermore,
candidate
bioactive
compound
suggested
through
analysis
using
gas
chromatography-mass
spectroscopy
ultra-high
performance
liquid
chromatography-quadrupole
time-of-flight
mass
spectroscopy.
In
conclusion,
may
alleviate
treat
obesity-induced
atrophy.
Andrologia,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Cadmium
(Cd),
an
environmental
pollutant
present
in
soil,
water,
and
food,
is
known
to
pose
significant
risks
male
reproductive
health
by
inducing
oxidative
stress
toxicity.
Scrophularia
striata
extract
(SSE)
rich
natural
antioxidants
that
play
a
crucial
role
neutralizing
toxins
protecting
various
organs.
This
study
aimed
evaluate
the
therapeutic
potential
of
SSE
mitigating
testicular
damage
impairments
spermatogenesis
induced
Cd
using
animal
model.
Adult
mice
were
randomly
assigned
six
groups:
control,
Cd,
100
mg/kg,
200
mg/kg
plus
Cd.
Mice
intraperitoneally
injected
with
0.35
for
35
days,
or
without
SSE.
At
study’s
conclusion,
parameters
assessed,
including
sperm
count,
motility,
viability,
morphology,
DNA
integrity,
testosterone
levels,
histopathology,
levels
malondialdehyde
(MDA),
nitric
oxide
(NO),
total
antioxidant
capacity
(TAC)
testes.
The
results
demonstrated
significantly
improved
spermatogenesis,
as
indicated
chromatin
integrity.
Additionally,
histopathology
notably
SSE‐treated
groups.
While
exposure
elevated
testes,
treatment
effectively
enhanced
defense
increasing
TAC
reducing
NO
MDA
levels.
Overall,
provided
substantial
protection
against
chronic
modulating
stress,
highlighting
its
promising
herbal
therapy
addressing
toxicity
infertility
linked
pollutants.
Cells,
Journal Year:
2022,
Volume and Issue:
11(18), P. 2845 - 2845
Published: Sept. 12, 2022
Preservation
of
human
spermatozoa
in
vitro
at
normothermia
or
hypothermia
maintaining
their
functions
and
fertility
for
several
days
plays
a
significant
role
reproductive
biology
medicine.
However,
it
is
well
known
that
left
deteriorate
over
time
irreversibly
as
the
consequence
various
stresses
such
change
osmolarity,
energy
deficiency,
oxidative
damage,
leading
to
substantial
limitations
including
need
semen
examinations,
preservation,
assisted
technology.
These
problems
may
be
addressed
with
aid
non-freezing
storage
techniques.
The
main
most
effective
preservation
strategies
are
partial
total
replacement
seminal
plasma
culture
medium,
named
extenders,
temperature-induced
metabolic
restriction.
Semen
extenders
consist
buffers,
osmolytes,
antioxidants,
etc.
protect
against
above-mentioned
adverse
factors.
Extended
has
negative
effect
on
sperm
parameters,
whereas
its
ART
outcomes
remains
inconsistent.
duration,
temperature,
pre-treatment
should
determined
according
aims
preservation.
Advanced
techniques
nanotechnology
omics
have
been
introduced
show
great
potential
lifespan
extension
sperm.
It
certain
more
patients
will
benefit
from
near
future.
This
review
provided
an
overview
current
knowledge
prospects
prolonged
vitro.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2023,
Volume and Issue:
38(1)
Published: Oct. 4, 2023
Abstract
There
is
a
growing
concern
that
antidepressant
drugs
impair
sexual
function
and
adversely
impact
spermatogenesis
male
fertility.
Vitamin
C
natural
antioxidant
plays
vital
role
in
the
reproductive
system.
The
present
study
investigated
ameliorating
potential
of
vitamin
against
citalopram
(CTL)‐evoked
testicular
toxicity
impairment
mice.
Mice
were
randomly
divided
into
six
groups:
control,
CTL,
100,
200,
CTL
plus
200.
Adult
mice
intraperitoneally
(ip)
injected
with
10
mg/kg
for
35
days
or
without
C.
At
end
study,
body
testes
weight,
sperm
parameters,
histopathology
testes,
testosterone
level,
levels
malondialdehyde
(MDA),
nitric
oxide
(NO),
total
capacity
(TAC),
apoptosis
(TUNEL
assay)
evaluated.
Our
findings
revealed
restored
by
improving
count,
motility,
viability,
morphology,
chromatin
integrity.
Testosterone
significantly
improved
C‐administrated
groups.
Furthermore,
administration
markedly
alleviated
CTL‐induced
nitro‐oxidative
damage,
enhancing
TAC
levels,
reducing
NO
MDA
levels.
Whilst
therapy
induced
significant
increase
number
TUNEL‐positive
cells
compared
to
prevented
apoptotic
effects
CTL.
Together,
protects
damage
via
mitigating
stress
apoptosis,
which
provides
evidence
as
beneficial
drug‐associated
sub/infertility.
Journal of Obstetrics and Gynaecology Research,
Journal Year:
2023,
Volume and Issue:
49(4), P. 1180 - 1188
Published: Feb. 3, 2023
Abstract
Aim
The
present
study
aimed
to
explore
the
potential
ameliorative
effects
of
L‐arginine
(LA),
L‐carnitine
(LC),
and
bone
marrow
mesenchymal
stem
cell‐conditioned
medium
(BMSC‐CM)
on
endometriosis
(EMS)
model
in
vivo
vitro.
Methods
animals
were
divided
into
two
main
groups,
normal
EMS‐induced
mice.
Normal
groups
injected
with
or
without
LA
(250
mg/kg),
LC
BMSC‐CM
(a
final
volume
100
μL
CM/mouse).
At
end
study,
level
total
antioxidant
capacity
(TAC),
nitric
oxide
(NO),
oxidative
status
(TOS)
measured
plasma.
Furthermore,
immature
oocytes
collected
from
cultured
a
maturation
medium.
Subsequently,
rates
vitro
maturation,
fertilization
(IVF),
embryonic
development
evaluated.
Results
results
revealed
that
administration
LA,
LC,
ameliorated
through
maintaining
TAC
alleviating
TOS
NO
levels.
More
importantly,
rates,
blastocyst
development,
cell
numbers
significantly
increased
BMSC‐CM‐administrated
compared
control
group.
In
both
EMS
highest
IVF,
cleavage,
percentages
associated
treatment
(
p
<
0.05).
Conclusion
Altogether,
have
therapeutic
impaired
oocyte
quality
promote
subsequent
vitro,
probably
normalization
nitro‐oxidative
stress,
thus
offering
alternatives
conventional
therapies
during
assisted
reproductive
technologies
for
patients
EMS‐associated
sub/infertility.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: May 19, 2023
Platostoma
palustre
(or
Mesona
chinensis
Benth)
is
an
important
medicinal
and
edible
plant
in
China
Southeast
Asian
countries.
To
study
the
effects
of
different
processing
methods
on
quality,
nutrition,
flavor
P.
,
we
adopted
LC-MS
HS-GC-MS
to
compare
influences
tedding
(S),
sweating
(M),
drying
(H)
metabolites
volatile
substances
.
Biochemical
determinations
revealed
that
M
treatment
could
promote
accumulation
contents
total
sugar,
soluble
pectin
compared
with
H
S
treatments
but
decrease
flavonoid
contents.
uncovered
98
differential
27
among
three
treatments,
respectively.
Overall,
facilitated
stabilization
improvement
quality
polysaccharides
substances,
while
level
amino
acids
The
current
provided
a
theoretical
reference
for
establishing
standardized
sustaining
stability
future.
