Novel Research in Microbiology Journal,
Journal Year:
2023,
Volume and Issue:
7(6), P. 2188 - 2198
Published: Nov. 1, 2023
Vulvovaginal
Candidiasis
(VVC)
is
a
significant
public
health
concern,
and
current
article
focuses
primarily
on
understanding
this
infection's
molecular
processes.
The
hosts
defence
mechanisms
their
dysregulation,
such
as
the
innate
immune
response
genetic
susceptibility
factors,
play
crucial
role
in
determining
to
VVC.
Candida-host
interactions
vaginal
environment,
including
adhesion
tissue
invasion,
have
been
extensively
investigated,
revealing
intricate
strategies
employed
by
Candida
spp.
colonize
persist
human
host.
Moreover,
virulence
factors
secreted
spp.,
hydrolytic
enzymes
toxins,
contribute
damage
modulation
of
response,
aiding
survival
evasion
host
defences.
formation
biofilms
complex
structures,
which
are
composed
fungal
cells
encased
an
extracellular
matrix,
has
emerged
essential
aspect
VVC
pathogenesis.
Biofilms
confer
enhanced
resistance
antifungal
agents,
leading
treatment
challenges
recurrent
infections.
Advancements
various
diagnostic
techniques
also
played
pivotal
research.
Molecular
diagnostics,
next-generation
sequencing,
proteomic
approaches
offer
improved
accuracy
rapid
identification
enabling
precise
diagnosis
personalized
strategies.
Such
for
developing
novel
therapeutic
targets,
disrupting
mechanisms,
inhibiting
factor
production,
targeting
biofilm
formation.
These
advances
hold
promise
more
effective
preventive
strategies,
interventions,
tools.
Overall,
review
aimed
discuss
recent
research
that
provides
valuable
insights
into
infection
driving
vulvovaginal
diagnosis,
ultimately
improving
quality
life
women
affected
disease.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(3), P. 186 - 186
Published: Feb. 28, 2024
Kodamaea
ohmeri
is
an
environmental
yeast
considered
a
rare
emerging
pathogen.
In
clinical
settings,
the
correct
identification
of
this
relevant
because
some
isolates
are
associated
with
resistance
to
antifungals.
There
lack
available
data
regarding
geographical
distribution,
virulence,
and
drug
profile
K.
ohmeri.
To
contribute
knowledge
yeast,
study
aimed
describe
in
depth
three
fungemia
Honduras.
The
was
carried
out
by
sequencing
ribosomal
ITS
region.
addition,
susceptibility
antifungals
determined,
properties
virulence
were
evaluated
(exoenzyme
production,
biofilm
formation,
cell
adhesion,
invasion).
showed
strong
protease,
phospholipase,
hemolysin
activity,
addition
being
producers.
Adherence
invasion
capacity
evident
HeLa
Raw
264.7
lines,
respectively.
This
expands
understanding
underlying
biological
traits
ohmeri,
it
first
report
detection
Honduras
as
cause
human
infection.
Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(9), P. 879 - 879
Published: Aug. 27, 2023
Candidiasis
is
one
of
the
most
frequent
nosocomial
infections
affecting
an
increasing
number
at-risk
patients.
Candida
albicans
remains
causative
agent
candidiasis,
but,
in
last
decade,
C.
auris
has
emerged
as
a
formidable
multi-drug-resistant
pathogen.
Both
species
are
fully
capable
forming
biofilms,
which
contribute
to
resistance,
urgency
for
new
effective
antifungal
therapies.
Repurposing
existing
drugs
could
significantly
accelerate
development
novel
therapies
against
candidiasis.
Here,
we
have
screened
Hub
library
from
Broad
Institute,
containing
over
6000
compounds,
search
inhibitors
and
biofilm
formation.
The
primary
screen
identified
57
initial
hits
33
auris.
Confirmatory
concentration-dependent
assays
were
used
validate
activity
and,
at
same
time,
establish
their
anti-biofilm
potency.
Based
on
these
results,
ebselen,
temsirolimus,
compound
BAY
11-7082
leading
repositionable
compounds.
Subsequent
experiments
established
spectrum
yeasts
filamentous
fungi.
In
addition,
vivo
was
examined
murine
models
hematogenously
disseminated
infections.
Although
promising,
further
vitro
studies
needed
confirm
potential
use
therapy
candidiasis
possibly
other
fungal
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 17, 2023
Candida
albicans
is
a
diploid
human
fungal
pathogen
that
displays
significant
genomic
and
phenotypic
heterogeneity
over
range
of
virulence
traits
in
the
context
variety
environmental
niches.
Here,
we
show
effects
Rob1
on
biofilm
filamentation
dependent
both
specific
condition
clinical
strain
C.
.
The
reference
SC5314
ROB1
heterozygote
with
two
alleles
differ
by
single
nucleotide
polymorphism
at
position
946
resulting
serine
or
proline
containing
isoform.
An
analysis
224
sequenced
genomes
indicates
only
documented
to
date
dominant
allele
contains
946.
Remarkably,
are
functionally
distinct
rare
946S
supports
increased
vitro
formation
vivo,
suggesting
it
gain-of-function
allele.
amongst
most
highly
filamentous
invasive
strains
characterized
date.
Introduction
into
poorly
filamenting
isolate
increases
conversion
an
laboratory
homozygote
formation.
In
mouse
model
oropharyngeal
infection,
predominant
946P
establishes
commensal
state
while
phenocopies
parent
invades
mucosae.
These
observations
provide
explanation
for
phenotypes
highlight
role
heterozygosity
as
driver
heterogeneity.
fungus
colonizes
oral
cavity
gastrointestinal
tracts
but
also
causes
mucosal
well
disease.
expression
isolates
heterogenous
genetic
basis
this
high
interest.
expresses
robust
relative
many
other
isolates.
derivatives
heterozygous
transcription
factor
contain
SNP
drives
filamentation,
formation,
candidiasis.
finding
explain,
part,
outlier
phenotype
plays
strain-to-strain
variation
pathogens.
Mycological Progress,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: June 20, 2024
Abstract
The
present
study
suggests
that
the
Esca
pathogenic
fungus
Phaeomoniella
chlamydospora
can
form
biofilm
in
vitro
and
possibly
grapevine
host
tissues.
This
phenomenon
was
revealed
by
detailed
examination
of
development
three
isolates
fungus,
showing
dimorphic
growth
with
formation
yeast-like
cells
center,
which
were
embedded
a
polysaccharide-rich
extracellular
matrix,
filamentous
at
colony
margins.
colonies
produced
acetate,
chemical
proved
to
be
an
enhancer
matrix
production.
dynamic
correlated
ability
strains
produce
suggesting
it
acts
as
quorum
sensing
molecule
process.
P.
also
demonstrated
tissues
sole
nutrient
source,
planta
take
part
pathogenesis
Esca.
biofilms
formed
may
contribute
previously
reported
inhibition
sap
flow
infected
plants,
while
its
sensing-mediated
nature
partly
explain
controversial
literature
data
on
occurrence
pathogen
symptom
severity
host.
Novel Research in Microbiology Journal,
Journal Year:
2023,
Volume and Issue:
7(6), P. 2188 - 2198
Published: Nov. 1, 2023
Vulvovaginal
Candidiasis
(VVC)
is
a
significant
public
health
concern,
and
current
article
focuses
primarily
on
understanding
this
infection's
molecular
processes.
The
hosts
defence
mechanisms
their
dysregulation,
such
as
the
innate
immune
response
genetic
susceptibility
factors,
play
crucial
role
in
determining
to
VVC.
Candida-host
interactions
vaginal
environment,
including
adhesion
tissue
invasion,
have
been
extensively
investigated,
revealing
intricate
strategies
employed
by
Candida
spp.
colonize
persist
human
host.
Moreover,
virulence
factors
secreted
spp.,
hydrolytic
enzymes
toxins,
contribute
damage
modulation
of
response,
aiding
survival
evasion
host
defences.
formation
biofilms
complex
structures,
which
are
composed
fungal
cells
encased
an
extracellular
matrix,
has
emerged
essential
aspect
VVC
pathogenesis.
Biofilms
confer
enhanced
resistance
antifungal
agents,
leading
treatment
challenges
recurrent
infections.
Advancements
various
diagnostic
techniques
also
played
pivotal
research.
Molecular
diagnostics,
next-generation
sequencing,
proteomic
approaches
offer
improved
accuracy
rapid
identification
enabling
precise
diagnosis
personalized
strategies.
Such
for
developing
novel
therapeutic
targets,
disrupting
mechanisms,
inhibiting
factor
production,
targeting
biofilm
formation.
These
advances
hold
promise
more
effective
preventive
strategies,
interventions,
tools.
Overall,
review
aimed
discuss
recent
research
that
provides
valuable
insights
into
infection
driving
vulvovaginal
diagnosis,
ultimately
improving
quality
life
women
affected
disease.
