Cardiovascular disease in patients with severe mental illness

Nature Reviews Cardiology, Journal Year: 2020, Volume and Issue: 18(2), P. 136 - 145

Published: Oct. 30, 2020

Language: Английский

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Mental health status of individuals with a mood-disorder during the COVID-19 pandemic in Australia: Initial results from the COLLATE project

Journal of Affective Disorders, Journal Year: 2020, Volume and Issue: 275, P. 69 - 77

Published: July 2, 2020

Language: Английский

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The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management

World Psychiatry, Journal Year: 2022, Volume and Issue: 21(3), P. 364 - 387

Published: Sept. 8, 2022

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to treatment. Despite evidence for the efficacy of multimodal-ity interventions, majority persons affected by this do not achieve sustain full syndromal recovery. It eagerly anticipated that combining datasets across various information sources (e.g., hierarchical "multi-omic" measures, electronic health records), analyzed using advanced computational methods machine learning), will inform future diagnosis treatment selection. In interim, identifying clinically meaningful subgroups with having differential specific treatments at point-of-care an empirical priority. This paper endeavours synthesize salient domains clinical characterization adult patient bipolar disorder, overarching aim improve outcomes informing management considerations. Extant data indicate characterizing select provides actionable guides shared decision making. For example, it robustly established presence mixed features - especially during depressive episodes physical psychiatric comorbidities informs treatment, suicide risk. addition, early environmental exposures sexual abuse, emotional neglect) are highly associated more complicated presentations, inviting need developmentally-oriented integrated approaches. There have been significant advances validating subtypes I vs. II disorder), particularly regard pharmacological interventions. As other severe mental disorders, social functioning, interpersonal/family relationships internalized stigma relevant relapse risk, outcomes, quality life. The elevated standardized mortality ratio completed suicidal behaviour invites domain all patients. framework describe above domains, providing a synthesis extant literature recommendations support tools metrics can be implemented point-of-care.

Language: Английский

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All-cause and cause-specific mortality among people with bipolar disorder: a large-scale systematic review and meta-analysis

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2508 - 2524

Published: June 1, 2023

Abstract Objective Bipolar disorder (BD) is associated with premature mortality. All-cause and specific mortality risks in this population remain unclear, more studies are still needed to further understand issue guide individual public strategies prevent bipolar Thus, a systematic review meta‐analysis of assessing risk people BD versus the general was conducted. The primary outcome all‐cause mortality, whilst secondary outcomes were due suicide, natural, unnatural, specific‐causes Results Fifty-seven included (BD; n = 678,353). All‐cause increased (RR 2.02, 95% CI: 1.89–2.16, k 39). Specific‐cause highest for suicide 11.69, 9.22–14.81, 25). Risk death unnatural causes 7.29, 6.41–8.28, 17) natural 1.90, 1.75–2.06, also increased. Among analyzed, infectious had higher RR 4,38, 95%CI: 1.5–12.69, 3), but analysis limited by inclusion few studies. Mortality respiratory 3.18, 2.55–3.96, 6), cardiovascular 1.76, 1.53–2.01, 27), cerebrovascular 1.57, 1.34–1.84, 13) as well. No difference identified cancer 0.99, 0.88–1.11, 16). Subgroup analyses meta-regression did not affect findings. Conclusion presented meta-analysis show that only causes, somatic comorbidities implicated. Not prevention promotion physical health conditions individuals may mitigate population. Notwithstanding our knowledge largest synthesis evidence on BD-related well-designed warranted inform field.

Language: Английский

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Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(11), P. 1591 - 1610

Published: Nov. 18, 2022

Obesity promotes diverse pathologies, including atherosclerosis and dementia, which frequently involve vascular defects endothelial cell (EC) dysfunction. Each organ has distinct EC subtypes, but whether ECs are differentially affected by obesity is unknown. Here we use single-cell RNA sequencing to analyze transcriptomes of ~375,000 from seven organs in male mice at progressive stages identify organ-specific vulnerabilities. We find that deregulates gene expression networks, lipid handling, metabolic pathways AP1 transcription factor inflammatory signaling, an organ- EC-subtype-specific manner. The transcriptomic aberrations worsen with sustained only partially mitigated dietary intervention weight loss. For example, substantially attenuates dysregulation liver, not kidney, transcriptomes. Through integration human genome-wide association study data, further a subset disease risk genes induced obesity. Our work catalogs the impact on endothelium, constitutes useful resource reveals leads for investigation as potential therapeutic targets.

Language: Английский

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Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(9), P. 3731 - 3737

Published: June 14, 2022

Abstract Schizophrenia is frequently associated with obesity, which linked neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto changes in schizophrenia. We obtained MRI-derived cortical and subcortical measures body mass index (BMI) from 1260 individuals schizophrenia 1761 controls 12 independent research sites within ENIGMA-Schizophrenia Working Group. jointly modeled statistical effects BMI using mixed effects. was additively structure many same regions as schizophrenia, but alterations were more widespread pronounced. Both primarily thickness, fewer surface area. While, negatively significant associations between area or volumes positive. Lastly, replicated among large studies closely resembled major depressive disorders. confirmed People both showed pronounced than people only one these conditions. Obesity appears to be a relevant factor could account for heterogeneity imaging findings differences outcomes

Language: Английский

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Stellate ganglion block in disparate treatment-resistant mental health disorders: A case series

Scandinavian Journal of Pain, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 1, 2025

Abstract Objectives A significant subset of patients with mental health disorders (MHDs) fail to respond standard management and are termed as treatment-resistant. This cohort has limited options for managing their condition. Autonomic dysfunction been reported in the neurobiology MHDs including anxiety, depression, obsessive-compulsive disorder (OCD), panic disorder, bipolar (BD). Stellate ganglion block (SGB) is an emerging treatment that dampens sympathetic activity shown be benefit post-traumatic stress disorder. Methods Patients treatment-resistant disparate were reviewed by a multidisciplinary team comprising psychiatrist, clinical psychologist, pain medicine physician. offered SGB novel strategy conditions. Validated outcome measures completed at baseline, 4 weeks, 16 weeks post-intervention. Results Four heterogenous who received presented this report. resulted improvement BD, OCD alcohol addiction, opioid anxiety. Conclusion could have role MHDs.

Language: Английский

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Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis

Frontiers in Psychology, Journal Year: 2021, Volume and Issue: 12

Published: June 3, 2021

This study aimed to conduct a bibliometric analysis of published studies on the association between coronary heart disease (CHD) and depression or anxiety. The also identify leading authors, institutions, countries determine research hotspots obtain some hints from speculated future frontiers. Publications about CHD anxiety 2004 2020 were collected Web Science Core Collection (WOSCC) database. Bibliographic information, such as authorship, country, citation frequency, interactive visualization, was generated using VOSviewer1.6.16 CiteSpace5.6.R5. In total, 8,073 articles identified in WOSCC United States (2,953 publications), Duke University Harvard (214 Psychosomatic Medicine (297 Denollet Johan. (99 publications) most productive journal, author, respectively. three “The relationship CHD,” “depression myocardial infarction,” characteristic women suffering after MI.” four frontiers are predicted be “treating patients with multimorbidity,” “psychometric properties instruments for assessing patients,” post-PCI “other mental diseases patients.” Bibliometric depressive disorders might new directions research.

Language: Английский

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Obesity as a Risk Factor for Accelerated Brain Ageing in First-Episode Psychosis—A Longitudinal Study

Schizophrenia Bulletin, Journal Year: 2021, Volume and Issue: 47(6), P. 1772 - 1781

Published: May 6, 2021

Abstract Background Obesity is highly prevalent in schizophrenia, with implications for psychiatric prognosis, possibly through links between obesity and brain structure. In this longitudinal study first episode of psychosis (FEP), we used machine learning structural magnetic resonance imaging (MRI) to the impact psychotic illness on ageing/neuroprogression shortly after onset. Methods We acquired 2 prospective MRI scans average 1.61 years apart 183 FEP 155 control individuals. a model trained an independent sample 504 controls estimate individual ages participants calculated BrainAGE by subtracting chronological from estimated age. Results Individuals had higher initial than (3.39 ± 6.36 vs 1.72 5.56 years; β = 1.68, t(336) 2.59, P .01), but similar annual rates ageing over time (1.28 2.40 1.07±1.74 years/actual year; t(333) 0.93, .18). Across both cohorts, greater baseline body mass index (BMI) predicted faster (β 0.08, .01). For each additional BMI point, aged month per year. Worsening functioning (Global Assessment Functioning; −0.04, t(164) −2.48, .01) increases especially negative symptoms Positive Negative Syndrome Scale 0.11, t(175) 3.11, .002) were associated FEP. Conclusions Brain alterations are manifest already during get worse those worsening clinical outcomes or BMI. As ageing, may represent modifiable risk factor that linked via effects

Language: Английский

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Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 26(11), P. 6806 - 6819

Published: April 16, 2021

Abstract Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived subcortical volumes and body mass index (BMI) 1134 1601 control individuals 17 independent research sites within ENIGMA-BD Working Group. jointly modeled BMI using mixed-effects modeling tested for mediation group differences by nonparametric bootstrapping. All models controlled age, sex, hemisphere, total intracranial volume, data collection site. Relative to controls, had significantly higher BMI, larger lateral ventricular smaller amygdala, hippocampus, pallidum, caudate, thalamus. was positively amygdala negatively pallidal volumes. When analyzed jointly, both remained ventricles amygdala. Adjusting decreased vs volume. Specifically, 18.41% association between volume mediated ( Z = 2.73, p 0.006). similar regional as BD, including ventricles, pallidum. Higher may part account one most replicated findings BD. Comorbidity could explain why alterations more pronounced some Future prospective imaging studies should investigate whether be a modifiable risk factor neuroprogression.

Language: Английский

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