Advanced Drug Delivery Reviews,
Journal Year:
2022,
Volume and Issue:
189, P. 114467 - 114467
Published: July 30, 2022
Despite
significant
advances
in
early
detection
and
personalized
treatment,
cancer
is
still
among
the
leading
causes
of
death
globally.
One
possible
anticancer
approaches
that
presently
receiving
a
lot
attention
development
nanocarriers
capable
specific
efficient
delivery
drugs.
Graphene-based
materials
are
promising
this
respect,
due
to
their
high
drug
loading
capacity
biocompatibility.
In
review,
we
present
an
overview
on
interactions
graphene-based
with
normal
mammalian
cells
at
molecular
level
as
well
cellular
subcellular
levels,
including
plasma
membrane,
cytoskeleton,
membrane-bound
organelles
such
lysosomes,
mitochondria,
nucleus,
endoplasmic
reticulum,
peroxisome.
parallel,
assemble
knowledge
about
cancerous
cells,
considered
potential
applications
these
for
therapy
metastasis
targeted
delivery,
differentiation
non-cancer
stem
cells.
We
highlight
influence
key
parameters,
size
surface
chemistry
govern
efficiency
internalization
biocompatibility
particles
vitro
vivo.
Finally,
review
aims
correlate
parameters
nanomaterials
specially
graphene
oxide,
modifications,
non-cancerous
designing
engineering
them
bio-applications
especially
therapeutic
purposes.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
11
Published: Feb. 12, 2021
The
immune
system
has
to
cope
with
a
wide
range
of
irregularly
shaped
pathogens
that
can
actively
move
(e.g.,
by
flagella)
and
also
dynamically
remodel
their
shape
transition
from
yeast-shaped
hyphal
fungi).
goal
this
review
is
draw
general
conclusions
how
the
size
geometry
pathogen
affect
its
uptake
processing
phagocytes
system.
We
compared
both
theoretical
experimental
studies
different
cells,
model
particles,
pathogenic
microbes
(particularly
fungi)
showing
particle
size,
shape,
rigidity,
surface
roughness
are
important
parameters
for
cellular
subsequent
responses,
particularly
inflammasome
activation
T
cell
activation.
Understanding
physical
properties
particles
responses
aid
design
better
vaccines.
Journal of Nanobiotechnology,
Journal Year:
2018,
Volume and Issue:
16(1)
Published: Dec. 1, 2018
Atomic
force
microscopy
(AFM)
allows
for
nanometer-scale
investigation
of
cells
and
molecules.
Recent
advances
have
enabled
its
application
in
cancer
research
diagnosis.
The
physicochemical
properties
live
undergo
changes
when
their
physiological
conditions
are
altered.
These
can
therefore
reflect
complex
processes
occurring
cells.
When
the
process
carcinogenesis
stimulated
by
external
stimuli,
morphology,
elasticity,
adhesion
may
change.
AFM
perform
surface
imaging
ultrastructural
observation
with
atomic
resolution
under
near-physiological
conditions,
collecting
spectroscopy
information
which
study
mechanical
For
this
reason,
has
potential
to
be
used
as
a
tool
high
into
ultrastructure
tumor
This
review
describes
working
principle,
mode,
technical
points
microscopy,
reviews
applications
prospects
research.
Cell Communication and Signaling,
Journal Year:
2021,
Volume and Issue:
19(1)
Published: March 10, 2021
Abstract
The
epithelial-mesenchymal
transition
(EMT)
is
intrinsically
linked
to
alterations
of
the
intracellular
cytoskeleton
and
extracellular
matrix.
After
EMT,
cells
acquire
an
elongated
morphology
with
front/back
polarity,
which
can
be
attributed
actin-driven
protrusion
formation
as
well
gain
vimentin
expression.
Consequently,
deform
remodel
surrounding
matrix
in
order
facilitate
local
invasion.
In
this
review,
we
highlight
recent
bioengineering
approaches
elucidate
EMT
functional
changes
cytoskeleton.
First,
review
transitions
between
multicellular
clusters
dispersed
individuals
on
planar
surfaces,
often
exhibit
coordinated
behaviors
driven
by
leader
EMT.
Second,
consider
role
vimentin,
probed
at
subcellular
length
scales
within
confined
spaces.
Third,
discuss
topographical
patterning
via
a
contact
guidance
like
mechanism.
Finally,
address
how
disorganize
disseminate
3D
These
new
technologies
enable
controlled
physical
microenvironments
higher-resolution
spatiotemporal
measurements
single
cell
level.
closing,
future
directions
for
field
outstanding
questions
regarding
human
cancer
progression.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
269, P. 115905 - 115905
Published: Jan. 1, 2024
Coal
fly
ash
(CFA),
a
byproduct
of
coal
combustion,
is
hazardous
industrial
solid
waste.
Its
excessive
global
production,
coupled
with
improper
disposal
practices,
insufficient
utilization
and
limited
awareness
its
inherent
hazards,
poses
significant
threat
to
both
ecological
environment
human
health.
Based
on
the
physicochemical
properties
CFA
leachates,
we
elucidate
forms
potential
pathways
for
entry
into
body,
as
well
leaching
behavior,
maximum
tolerance
biological
half-life
toxic
elements
present
in
CFA.
Furthermore,
provide
an
overview
current
strategies
methods
mitigating
these
harmful
from
Moreover,
systemically
summarize
effect
organisms
across
various
tiers
complexity,
analyze
epidemiological
findings
concerning
health
implications
resulting
exposure,
delve
biotoxicological
mechanisms
leachates
at
cellular
molecular
levels.
This
review
aims
enhance
understanding
toxicity
CFA,
thereby
promoting
increased
public
regarding
management
this
Annual Review of Biophysics,
Journal Year:
2024,
Volume and Issue:
53(1), P. 367 - 395
Published: Feb. 21, 2024
The
mechanical
phenotype
of
a
cell
determines
its
ability
to
deform
under
force
and
is
therefore
relevant
cellular
functions
that
require
changes
in
shape,
such
as
migration
or
circulation
through
the
microvasculature.
On
practical
level,
can
be
used
global
readout
cell's
functional
state,
marker
for
disease
diagnostics,
an
input
tissue
modeling.
We
focus
our
review
on
current
knowledge
structural
components
contribute
determination
properties
highlight
physiological
processes
which
cells
critical
relevance.
ongoing
efforts
understand
how
efficiently
measure
control
will
define
progress
field
drive
phenotyping
toward
clinical
applications.
Nanoscale,
Journal Year:
2018,
Volume and Issue:
10(45), P. 20930 - 20945
Published: Jan. 1, 2018
AFM
measurements
could
be
employed
to
complement
standard
biopsy
procedures,
offering
an
objective,
novel
and
quantitative
diagnostic
approach
with
the
properties
of
a
blind
assay,
allowing
unbiased
evaluation
sample.
