Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression DOI Creative Commons
Zhiwei He, Kun Cai, Zhirui Zeng

et al.

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(3)

Published: March 14, 2022

Dysregulation of autophagy and circular RNAs (circRNAs) are involved in the pancreatic cancer (PC) progression. However, regulatory network between circRNAs, autophagy, PC progression remains unknown. Herein, we demonstrated that autophagy-associated circRNA circ-autophagy related 7 (circATG7) was elevated tissues compared to adjacent tissues, cells treated with EBSS hypoxia. circATG7 expression positively associated tumor diameter lymph node invasion patients PC. overexpression promoted cell proliferation, mobility, vitro, while knockdown induced opposite effects. ATG7 inhibition attenuated effects on biological functions cells. CircATG7 is located cytoplasm nucleus. Cytoplasmic sponged miR-766-5p decreased its expression, increased ATG7, a target gene miR-766-5p. Nuclear acted as scaffold increase interaction human antigen R protein mRNA enhanced ATG stability. Furthermore, regulates proliferation metastasis vivo via ATG7-dependent autophagy. In conclusion, our results accelerates miR-766-5p/ATG7 HUR/ATG7 depends autophagic flux. Thus, may be potential therapeutic for

Language: Английский

Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System DOI Open Access
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5954 - 5954

Published: May 25, 2022

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role information transmission throughout the nervous system. Hundreds of such chemicals have been discovered last century, continuing to be identified studied concerning their action on brain health. These substances observed influence numerous functions, including emotions, thoughts, memories, learning, movements. Thus, disturbances neurotransmitters' homeostasis started being correlated with a plethora neurological neurodegenerative disorders. In this respect, present paper aims describe most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) noncanonical neurotransmitters exosomes, steroids, D-aspartic acid), explain link some relevant conditions. Moreover, brief overview recently developed detection methods is offered, followed by several considerations modulation these towards restoring homeostasis.

Language: Английский

Citations

282
Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics DOI Creative Commons
Amir Ajoolabady,

Shuyi Wang,

Guido Kroemer

et al.

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 225, P. 107848 - 107848

Published: April 4, 2021

Language: Английский

Citations

223
The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies DOI Creative Commons
Stella Voulgaropoulou, Thérèse van Amelsvoort, Jos Prickaerts

et al.

Brain Research, Journal Year: 2019, Volume and Issue: 1725, P. 146476 - 146476

Published: Sept. 24, 2019

Alzheimer's disease constitutes a growing cause of cognitive impairment in aging population. Given that current treatments do not produce the desired therapeutic effects, need for finding alternative biological and pharmacological approaches is critical. Accumulating evidence suggests inflammatory oxidative stress responses as potential causal factors impairments healthy aging. Curcumin has received increased interest due to its unique molecular structure targets antioxidant pathways well (directly) amyloid aggregation; one major hallmarks disease. Therefore, this review summarizes preclinical clinical findings on curcumin enhancer normal Databases used literature searches include PubMed, EMBASE Web Science; addition, clinicaltrials.gov was search studies. Overall, animal research shown very promising results potentiating cognition, both physiologically behaviourally. However, human studies are limited less consistent, complicating their interpretation. These inconsistencies may be related differences methodology included Taking into account measurements important biomarkers, optimal dosages curcumin, food interactions, duration treatment would increase our understanding curcumin's effects cognition. In increasing bioavailability could benefit future research.

Language: Английский

Citations

199
Targeting autophagy-related protein kinases for potential therapeutic purpose DOI Creative Commons

Honggang Xiang,

Jifa Zhang,

Congcong Lin

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2019, Volume and Issue: 10(4), P. 569 - 581

Published: Oct. 18, 2019

Autophagy, defined as a scavenging process of protein aggregates and damaged organelles mediated by lysosomes, plays significant role in the quality control macromolecules organelles. Since kinases are integral to autophagy process, it is critically important understand autophagic regulation. At present, intervention processes small-molecule modulators targeting specific has becoming reasonable prevalent strategy for treating several varieties human disease, especially cancer. In this review, we describe some autophagy-related kinase targets kinase-mediated phosphorylation mechanisms We also summarize inhibitors/activators these targets, highlighting opportunities new therapeutic agents.

Language: Английский

Citations

189
Role of tau protein in Alzheimer's disease: The prime pathological player DOI
Shibi Muralidar, Senthil Visaga Ambi, Saravanan Sekaran

et al.

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 163, P. 1599 - 1617

Published: Aug. 9, 2020

Language: Английский

Citations

184
Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease DOI
Sachchida Nand, Charan Singh,

Arti Singh

et al.

Molecular Neurobiology, Journal Year: 2020, Volume and Issue: 57(7), P. 3075 - 3088

Published: May 27, 2020

Language: Английский

Citations

147
The Dual Role of Autophagy in Cancer Development and a Therapeutic Strategy for Cancer by Targeting Autophagy DOI Open Access
Chul Won Yun, Juhee Jeon, Gyeongyun Go

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 22(1), P. 179 - 179

Published: Dec. 26, 2020

Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful conditions, including the accumulation of damaged proteins and organelles as well nutrient deprivation. The mechanism autophagy initiated by creation autophagosomes, which capture encapsulate abnormal components. Afterward, autophagosomes assemble with lysosomes recycle or remove degradative cargo. regulation has bipolar roles in cancer suppression promotion cancers. Furthermore, modulates features tumorigenesis, metastasis, stem cells, drug resistance against anticancer agents. Some regulators are used modulate for therapy but dual limit their application therapy, present main reason failure. In this review, we summarize mechanisms autophagy, Finally, discuss whether targeting promising effective therapeutic strategy therapy.

Language: Английский

Citations

143
The effects of metformin on autophagy DOI Open Access
Guangli Lu, Zhen Wu, Jia Shang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 137, P. 111286 - 111286

Published: Jan. 30, 2021

Metformin is the first-line option for treating newly diagnosed diabetic patients and also involved in other pharmacological actions, including antitumor effect, anti-aging polycystic ovarian syndrome prevention, cardiovascular action, neuroprotective etc. However, mechanisms of metformin actions were not fully illuminated. Recently, increasing researches showed that autophagy a vital medium playing actions. Nevertheless, results on effects inconsistent. Apart from few clinical evidences, more data focused kinds no-clinical models. First, many studies could induce via number signaling pathways, AMPK-related pathways (e.g. AMPK/mTOR, AMPK/CEBPD, MiTF/TFE, AMPK/ULK1, AMPK/miR-221), Redd1/mTOR, STAT, SIRT, Na+/H+ exchangers, MAPK/ERK, PK2/PKR/AKT/ GSK3β, TRIB3. Secondly, some process inhibiting autophagy, such as (AMPK/NF-κB undetermined pathways), Hedgehog, miR-570-3p, miR-142-3p, MiR-3127-5p. Thirdly, two types PI3K/AKT/mTOR endoplasmic reticulum (ER) stress bidirectionally impact effectiveness autophagy. Finally, multiple signal reviewed collectively terms affecting The combining its discussed. It would help better apply to treat diseases term mediating

Language: Английский

Citations

126
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment DOI
Yasaman Esmaeili,

Zahra Yarjanli,

Fatemeh Pakniya

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 147 - 175

Published: March 4, 2022

Language: Английский

Citations

125
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy DOI Creative Commons
Liwen Luo,

Xiuying Jian,

Hui Sun

et al.

Stem Cells, Journal Year: 2021, Volume and Issue: 39(4), P. 467 - 481

Published: Jan. 18, 2021

Abstract Degeneration of the cartilage endplate (CEP) induces intervertebral disc degeneration (IVDD). Nucleus pulposus cell (NPC) apoptosis is also an important exacerbating factor in IVDD, but cascade mechanism IVDD not clear. We investigated NPCs and when stimulated by normal stem (CESC)-derived exosomes (N-Exos) degenerated CESC-derived (D-Exos) vitro vivo. Tert-butyl hydroperoxide (TBHP) was used to induce inflammation CESCs. The bioinformatics differences between N-Exos D-Exos were analyzed using mass spectrometry, heat map, Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis. NPC examined TUNEL staining. involvement AKT autophagy signaling pathways inhibitor LY294002. Magnetic resonance imaging, Western blotting, immunofluorescence staining evaluate therapeutic effects rats with IVDD. TBHP effectively induced CEP rat. more conducive activation than D-Exos. apoptotic rate decreased obviously after treatment compared inhibited attenuated rat via pathways. These results are first findings confirm that delayed progression exosomes. on inhibition slowing effective due PI3K/AKT/autophagy pathway, which explained increase incidence CEP.

Language: Английский

Citations

113