Phytotherapy Research,
Journal Year:
2022,
Volume and Issue:
36(3), P. 1326 - 1337
Published: Jan. 25, 2022
Traumatic
brain
injury
(TBI)
is
a
common
disease
worldwide
with
high
mortality
and
disability
rate
closely
related
to
the
inflammatory
response.
However,
molecular
mechanisms
during
pathophysiological
responses
are
not
completely
understood.
This
study
was
conducted
investigate
protective
effect
of
curcumin
on
TBI
p38/MAPK
signal
pathway.
We
found
that
remarkably
ameliorated
secondary
after
TBI,
including
effects
neurological
severity
score
inflammation.
After
injection
curcumin,
function
mice
decreased
significantly.
Curcumin
exhibited
antiinflammatory
pharmacological
effects,
as
reflected
by
inhibition
factors
(e.g.,
interleukin
[IL]-1β,
IL-6,
tumor
necrosis
factor
[TNF]-α).
Additionally,
notably
reduced
expression
p-p38
according
western
blotting
immunohistochemical
analyses.
In
conclusion,
alleviated
posttraumatic
inflammation
thus
shows
potential
for
treating
associated
TBI.
Phytotherapy Research,
Journal Year:
2021,
Volume and Issue:
36(1), P. 147 - 163
Published: Sept. 24, 2021
Piperine
(PIP)
is
an
alkaloid
found
primarily
in
Piper
longum,
and
this
natural
compound
has
been
shown
to
exert
effects
on
proliferation
survival
against
various
types
of
cancer.
In
particular,
PIP
potent
inhibitory
breast
cancer
(BC),
the
most
prevalent
type
women
worldwide.
targets
numerous
signaling
pathways
associated
with
therapy
BC
cells
through
following
mechanisms:
(a)
induction
arrest
cell
cycle
apoptosis;
(b)
alteration
protein
expression;
(c)
reduction
transcription
factors;
(d)
inhibition
tumor
growth.
have
ability
resist
conventional
drugs,
so
one
strategies
combination
other
phytochemicals
such
as
paclitaxel,
thymoquinone,
hesperidin,
bee
venom,
tamoxifen,
mitoxantrone,
piperlongumin,
curcumin.
Nanotechnology-based
drug
encapsulation
systems
are
currently
used
enhance
release
PIP.
This
includes
polymer
nanoparticles,
carbon
nanotubes,
liposomes.
present
review,
chemistry
bioavailability
PIP,
its
molecular
BC,
nanotechnological
discussed.
Future
research
directions
also
discussed
further
understand
promising
product.
Phytotherapy Research,
Journal Year:
2022,
Volume and Issue:
36(3), P. 1241 - 1257
Published: Feb. 7, 2022
Gut
microbiota
plays
a
key
role
in
the
pathophysiology
of
type
2
diabetes
mellitus
(T2D).
Mulberry
leaf
has
hypoglycemic
effect,
but
potential
mechanism
is
not
fully
understood.
This
study
aimed
to
explore
influences
and
mechanisms
mulberry
water
extract
(MLWE)
intervention
on
mice
with
T2D
induced
through
high-fat
high-sucrose
diet
combined
streptozotocin
by
combination
fecal
metabolomics
gut
analysis.
Results
showed
that
MLWE
could
decrease
fasting
blood
glucose
body
weight
while
ameliorating
lipid
profiles,
insulin
resistance,
liver
inflammation,
accumulation
droplets
mice.
reverse
abundances
phyla
Actinobacteria
Bacteroidetes
ratio
Firmicutes/Bacteroidetes,
increase
Cyanobacteria
Epsilonbacteraeota
feces
The
genera
Alloprevotella,
Parabacteroides,
Muribaculaceae,
Romboutsia
be
reversed,
Oscillatoriales_cyanobacterium
Gastranaerophilales
reinforced
supplementation.
levels
nine
metabolites
were
improved,
among
which
glycine,
Phe-Pro,
urocanic
acid,
phylloquinone,
lactate
correlated
Gastranaerophilales.
Taken
together,
we
conclude
can
effectively
alleviate
mediating
host-microbial
metabolic
axis.
Phytotherapy Research,
Journal Year:
2022,
Volume and Issue:
36(5), P. 2246 - 2263
Published: April 8, 2022
Cannabis
sativa
L.
is
increasingly
emerging
for
its
protective
role
in
modulating
neuroinflammation,
a
complex
process
orchestrated
among
others
by
microglia,
the
resident
immune
cells
of
central
nervous
system.
Phytocannabinoids,
especially
cannabidiol
(CBD),
terpenes,
and
other
constituents
trigger
several
upstream
downstream
microglial
intracellular
pathways.
Here,
we
investigated
molecular
mechanisms
CBD-
terpenes-enriched
C.
extract
(CSE)
an
vitro
model
neuroinflammation.
We
evaluated
effect
CSE
on
inflammatory
response
induced
exposure
to
lipopolysaccharide
(LPS)
BV-2
cells,
compared
with
CBD
β-caryophyllene
(CAR),
CB2
receptors
(CB2r)
inverse
full
agonist,
respectively.
The
LPS-induced
upregulation
pro-inflammatory
cytokines
IL-1β,
IL-6,
TNF-α
was
significantly
attenuated
only
partially
CBD,
whereas
CAR
ineffective.
In
these
anti-inflammatory
effects
exerted
phytocomplex
were
dependent
CB2r
modulation
they
mediated
regulation
enzymes
responsible
endocannabinoids
metabolism,
inhibition
reactive
oxygen
species
release
JNK/p38
cascade
consequent
NF-κB
p65
nuclear
translocation
suppression.
Our
data
suggest
that
multitarget
mechanism
could
represent
novel
therapeutic
strategy
neuroinflammatory-related
diseases.
Phytotherapy Research,
Journal Year:
2022,
Volume and Issue:
36(3), P. 1326 - 1337
Published: Jan. 25, 2022
Traumatic
brain
injury
(TBI)
is
a
common
disease
worldwide
with
high
mortality
and
disability
rate
closely
related
to
the
inflammatory
response.
However,
molecular
mechanisms
during
pathophysiological
responses
are
not
completely
understood.
This
study
was
conducted
investigate
protective
effect
of
curcumin
on
TBI
p38/MAPK
signal
pathway.
We
found
that
remarkably
ameliorated
secondary
after
TBI,
including
effects
neurological
severity
score
inflammation.
After
injection
curcumin,
function
mice
decreased
significantly.
Curcumin
exhibited
antiinflammatory
pharmacological
effects,
as
reflected
by
inhibition
factors
(e.g.,
interleukin
[IL]-1β,
IL-6,
tumor
necrosis
factor
[TNF]-α).
Additionally,
notably
reduced
expression
p-p38
according
western
blotting
immunohistochemical
analyses.
In
conclusion,
alleviated
posttraumatic
inflammation
thus
shows
potential
for
treating
associated
TBI.
