Cited by Icariside II Alleviates Chondrocyte Inflammatory Injury by Inhibiting the TNIP2/NF-κB Pathway

Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis DOI

Jianmei Gao, Y.L. He, Feng Shi

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Sirt6-mediated gut microbiota plays a vital role in poststroke depression (PSD). Icariside Ⅱ (ICS Ⅱ) is naturally-occurring neuroprotectant with Sirt6 induction potency. However, it unknown whether ICS protects against PSD through modulation of microbiota. This study aimed to reveal the effect and potential mechanisms on PSD, microbiota-gut-brain axis was investigated. Using middle cerebral artery occlusion (MCAO) chronic unpredictable mild stress (CUMS) establish post-stroke (PSD) mice, we assessed anti-depressant effects via behavioral tests, immunohistochemistry, western blot. Transcriptome profiling, molecular docking, surface plasmon resonance were used identify key targets. 16S rDNA genomic-derived taxonomic profiling fecal transplantation (FMT) conducted figure out mechanistic short-chain fatty acids (SCFAs). ameliorated depressive-like behaviors mice as evidenced by sucrose preference test, forced swimming test tail suspension test. restored mitochondrial function, reduced oxidative damage pro-inflammatory cytokines both brain intestine regulation Sirt6/NF-κB pathway. significantly increased abundance (such asAkkermansia Ligilactobacillus), enhanced SCFAs concentrations, repaired intestinal barrier integrity upreglated tight junction protein expression. FMT from II-treated replicated these benefits, confirming microbiota's role. Mechanistically, directly bound its activity. Ⅱ-mediated neuroprotection neutralized or hydrogen peroxide-induced enteric glial cells when absent. Our findings expand pharmacological properties II demonstrating ability ameliorate axis. Ⅱ, novel activator, could be translated into an alternative microbiota-targeted avenue for coping PSD.

Language: Английский

Citations

Ferroptosis: an important player in the inflammatory response in diabetic nephropathy DOI

Jialing Li, Luxin Li, Zhen Zhang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 4, 2023

Diabetic nephropathy (DN) is a chronic inflammatory disease that affects millions of diabetic patients worldwide. The key to treating DN early diagnosis and prevention. Once the patient enters clinical proteinuria stage, renal damage difficult reverse. Therefore, developing treatment methods critical. pathogenesis results from various factors, among which immune response inflammation play major roles. Ferroptosis newly discovered type programmed cell death characterized by iron-dependent lipid peroxidation excessive ROS production. Recent studies have demonstrated activation closely related occurrence development ferroptosis. Moreover, hyperglycemia induces iron overload, peroxidation, oxidative stress, inflammation, fibrosis, all are pathogenesis, indicating ferroptosis plays role in DN. this review focuses on regulatory mechanisms ferroptosis, mutual processes involved inflammation. By discussing analyzing relationship between DN, we can deepen our understanding develop new therapeutics targeting or inflammation-related for with

Language: Английский

Citations

Epimedium Aqueous Extract Ameliorates Cerebral Ischemia/Reperfusion Injury through Inhibiting ROS/NLRP3-Mediated Pyroptosis DOI

Xiaoyu Wu,

Jiajia Wei,

Yang Yi

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 999 - 999

Published: April 25, 2023

Cerebral ischemia/reperfusion causes exacerbated neuronal damage involving excessive neuroinflammation and oxidative stress. ROS is considered a signal molecule to activate NLRP3; thus, the ROS/NLRP3/pyroptosis axis plays vital role in pathogenesis of cerebral injury (CIRI). Therefore, targeting inhibition may be promising therapeutic tactic for CIRI.

Language: Английский

Citations

Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway DOI

Juanjuan Han,

Li-nan Zhan,

Yue Huang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 1, 2024

Abstract Ferroptosis is a recently identified form of programmed cell death that plays an important role in the pathophysiological process osteoarthritis (OA). Herein, we investigated protective effect moderate mechanical stress on chondrocyte ferroptosis and further revealed internal molecular mechanism. Intra-articular injection sodium iodoacetate (MIA) was conducted to induce rat model OA vivo, meanwhile, interleukin-1 beta (IL-1β) treated chondrocytes vitro. The phenotype analyzed by histology microcomputed tomography, transmission electron microscope immunofluorescence. expression cartilage metabolism-related factors immunohistochemical Western blot. Animal experiments moderate-intensity treadmill exercise could effectively reduce matrix degradation MIA-induced rats. Cell showed 4-h cyclic tensile strain intervention activate Nrf2 inhibit NF-κB signaling pathway, increase Col2a1, GPX4, SLC7A11, decrease MMP13 P53, thereby restraining IL-1β-induced degeneration. Inhibition pathway relieved Meanwhile, overexpression recombinant lentivirus reversed positive CTS chondrocytes. Moderate antioxidant system, p65 regulating GPX4.

Language: Английский

Citations

Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease DOI

Yu Gu,

Zifan Hu,

Danwen Zheng

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 126, P. 155435 - 155435

Published: Feb. 13, 2024

Language: Английский

Citations

Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review DOI

Nemanja Živanović, Marija Lesjak, Nataša Simin

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 334 - 334

Published: March 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Language: Английский

Citations

Trilobatin suppresses aging-induced cognitive impairment by targeting SIRT2: Involvement of remodeling gut microbiota to mediate the brain-gut axis DOI

Dianyou Xie, Lin Mu,

Yun-mei Luo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155744 - 155744

Published: May 15, 2024

Language: Английский

Citations

Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization DOI

Lingling Deng,

Boshu Ouyang,

Hanlin Shi

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 317, P. 116810 - 116810

Published: June 17, 2023

Language: Английский

Citations

Trilobatin rescues fulminant hepatic failure by targeting COX2: Involvement of ROS/TLR4/NLRP3 signaling DOI

Fangqin Hou,

Xiaoyu Wu,

Miaoxian Gong

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 120, P. 155059 - 155059

Published: Sept. 1, 2023

Language: Английский

Citations

Natural flavonoids act as potent ferroptosis inhibitors and their potentials in the treatment of ferroptosis-associated diseases DOI

Lu Liu, Lun Wang,

Ying Xiao

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2024, Volume and Issue: 10, P. 100377 - 100377

Published: Jan. 26, 2024

Ferroptosis, an iron-dependent cell death characterized by lethal lipid peroxidation, has been involved in the pathogenesis of various diseases, such as ischemia/reperfusion injury, neurodegenerative and inflammatory disorders. Pharmacological inhibition ferroptosis represents a promising strategy for treatment above diseases. Flavonoids, class natural products found medicinal plants functional foods, are known numerous activities, especially newly discovered anti-ferroptotic activity. Our review aims to expand our understanding flavonoids' activity on multiple biological systems highlight importance utilizing flavonoids ferroptosis-associated A systematic literature search was conducted using Google Scholar, PubMed, Web Science, ScienceDirect, Springer Link. The following keywords: flavonoids, products, ferroptosis, mechanism, available information comprehensively studied compiled. We recent advances molecular mechanisms its roles diverse further systematically summarize inhibitory underlying suggest that ROS accumulation labile Fe2+ availability well activation Nrf2 signaling responsible inhibition. also discuss their clinical applications ferroptosis-related Taken together, exhibit prospect This is expected not only facilitate design development flavonoid-based inhibitors, but diseases therapies.

Language: Английский

Citations