Effects of Ginsenoside Rb1 on the Crosstalk between Intestinal Stem Cells and Microbiota in a Simulated Weightlessness Mouse Model DOI Open Access

Beibei Zong,

Jingyi Wang,

K. Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8769 - 8769

Published: Aug. 12, 2024

Exposure to the space microenvironment has been found disrupt homeostasis of intestinal epithelial cells and alter composition microbiota. To investigate this in more detail examine impact ginsenoside Rb1, we utilized a mouse model hindlimb unloading (HU) for four weeks simulate effects microgravity. Our findings revealed that HU mice had ileum injury with decrease number stem (ISCs) level cell proliferation. The niche functions ISCs were also impaired mice, including reduction Paneth Wnt signaling, along an increase oxidative stress. administration Rb1 during entire duration alleviated observed defects, suggesting its beneficial influence on homeostasis. Hindlimb resulted gut dysbiosis. supplementation or addition derivative compound K bacterial culture vitro promoted growth probiotic species such as Akkermansia. co-housing experiment further showed treatment ground control alone could alleviate defects co-housed Rb1-treated mice. Together, these results underscore close relationship between dysbiosis ISC model. It highlights mitigating HU-induced by promoting expansion probiotics. These animal-based insights provide valuable knowledge development improved approaches maintaining astronauts.

Language: Английский

Exploring the role of a novel postbiotic bile acid: Interplay with gut microbiota, modulation of the farnesoid X receptor, and prospects for clinical translation DOI
Beibei Wang, Dong Woo Han, Xin‐Yue Hu

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 287, P. 127865 - 127865

Published: Aug. 6, 2024

Language: Английский

Citations

7
Ginsenoside Rg1 Enriches Gut Microbial Indole-3-acetic acid to Alleviate Depression-like Behavior in Mice via Oxytocin Signaling DOI
Siqi Yu, Zhe Yin, Ming Ling

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156186 - 156186

Published: Oct. 28, 2024

Language: Английский

Citations

4
Traditional Chinese medicine Yiqi Huoxue Huatan recipe inhibits atherosclerosis by regulating intestinal flora and its associated metabolites DOI Creative Commons
Hongtao Huang,

Wei Lv,

Hanjun Zhao

et al.

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100593 - 100593

Published: Feb. 1, 2025

Language: Английский

Citations

0
Systemic lupus erythematosus and atherosclerosis: immune pathways and the uncharted territory of gut microbiota and metabolism DOI Creative Commons
Quanren Pan, Xuemei Huang, Chaobin Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Patients with Systemic Lupus Erythematosus (SLE) are significantly more susceptible to atherosclerosis, which may elevate their mortality risk. The review explores recent understandings of the origins and remedies for atherosclerosis associated SLE. Our focus is particularly on consequences immune system disparities, interruptions in intestinal bacteria, metabolic complications. influence SLE extends past usual risk elements, including processes specific disease. list encompasses excessive cell activity, production autoantibodies, inflammatory responses. A variety therapies linked encompass cholesterol-lowering medications, anti-inflammatory drugs, suppressors, antimalarials, interferon treatments, NET inhibitors, methods aimed at T B-cells. However, existing research has its shortcomings, necessitating additional clinical trials ascertain efficacy security these therapies. direct interactions among SLE, gut microbiota, metabolism, underexplored, presenting innovation opportunities. Research into microbial strains metabolites’ effects responses progression patients needed. Such could uncover novel therapeutic targets biomarkers, advancing prevention treatment strategies cardiovascular

Language: Английский

Citations

0
Metformin’s dual impact on Gut microbiota and cardiovascular health: A comprehensive analysis DOI Open Access
Turky Omar Asar, Fahad A. Al‐Abbasi, Ryan A. Sheikh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117128 - 117128

Published: July 29, 2024

Cardiovascular diseases (CVD) cause significant global morbidity, mortality and public health burden annually. CVD alters richness, diversity, composition of Gut microbiota along with RAS histopathological differences. Present study explores Metformin role in mitigating doxorubicin induced cardiovascular toxicity/remodeling. Animals were divided into 4 groups n=6: Group I (N. Control) free access to diet water; II (MET. on oral (250 mg/kg) daily; III (DOX. alternate day intraperitoneal Doxorubicin (3 totaling 18 mg/kg; IV MET. received both daily mg/kg). microbial analysis was made from stool before animals sacrificed for biochemical analysis. Significant alterations observed ɑ β-diversity new genus Firmicutes, specifically Clostridia_UCG-014, Eubacterium ruminantium, Tunicibacter, prevalent the DOX. Control DOX.MET groups. Proteobacteria, represented by Succinivibrio, absent all Additionally, Parabacteroides Bacteroidia phylum except N. control. In group, levels Angiotensin ( 7.75± 0.49 nmol/min, p<0.01) Renin (2.60±0.26 ng/ml/hr) significantly reduced. Conversely, CK-MB, Fibrinogen, Troponin, CRP p < 0.0001), TNFɑ (p 0.05) elevated. Histopathological examination revealed substantial cardiac changes, including Fibrinogen fat deposition eosinophilic infiltration, as well liver damage characterized binucleated cells damaged hepatocytes, altered renal tissues DOX.MET.Control group. The findings suggest that modifies gut microbiota, particularly impacting Firmicutes Proteobacteria phyla. reduction levels, alongside increased inflammatory markers myocardial damage, highlights complex interactions potential adverse effects associated MET therapy health.

Language: Английский

Citations

3
Metabolic insights into gut microbiota in the pharmacology of natural medicines DOI
Zixin Chen,

Junchi Zhou,

Xiao Zheng

et al.

Chinese Journal of Natural Medicines, Journal Year: 2025, Volume and Issue: 23(2), P. 158 - 168

Published: Feb. 1, 2025

Language: Английский

Citations

0
Effects of Ginsenoside Rb1 on the Crosstalk between Intestinal Stem Cells and Microbiota in a Simulated Weightlessness Mouse Model DOI Open Access

Beibei Zong,

Jingyi Wang,

K. Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8769 - 8769

Published: Aug. 12, 2024

Exposure to the space microenvironment has been found disrupt homeostasis of intestinal epithelial cells and alter composition microbiota. To investigate this in more detail examine impact ginsenoside Rb1, we utilized a mouse model hindlimb unloading (HU) for four weeks simulate effects microgravity. Our findings revealed that HU mice had ileum injury with decrease number stem (ISCs) level cell proliferation. The niche functions ISCs were also impaired mice, including reduction Paneth Wnt signaling, along an increase oxidative stress. administration Rb1 during entire duration alleviated observed defects, suggesting its beneficial influence on homeostasis. Hindlimb resulted gut dysbiosis. supplementation or addition derivative compound K bacterial culture vitro promoted growth probiotic species such as Akkermansia. co-housing experiment further showed treatment ground control alone could alleviate defects co-housed Rb1-treated mice. Together, these results underscore close relationship between dysbiosis ISC model. It highlights mitigating HU-induced by promoting expansion probiotics. These animal-based insights provide valuable knowledge development improved approaches maintaining astronauts.

Language: Английский

Citations

1