Exploring the impact of environmental factors on male reproductive health through epigenetics

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: 132, P. 108832 - 108832

Published: Jan. 6, 2025

Language: Английский

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Conceptual developments in sperm competition: a very brief synopsis

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2020, Volume and Issue: 375(1813), P. 20200061 - 20200061

Published: Oct. 18, 2020

The past half century has seen the development of field post-ejaculatory sexual selection, sequel to selection for mate-acquisition (pre-ejaculatory) described by Darwin. In richness and diversity adaptations, rivals that pre-ejaculatory selection. Anisogamy—and hence two sexes—likely arose primeval gamete competition, sperm competition remains a major force maintaining high numbers. equivalent male–male matings, was an intense ancestral form typically weakening as mobility internal fertilization developed in many taxa, when some expenditure became diverted into competition. Sperm theory been relatively successful explaining variation relative testes size numbers per ejaculate is becoming more phenotype. generated other male adaptations such seminal fluid proteins variously modify female reproduction towards interests, copulatory plugs, prolonged copulations guarding behaviour reduce remating probability, which result conflict. This short survey conceptual developments intended broad overview, mainly primer new researchers. article part theme issue ‘Fifty years competition'.

Language: Английский

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The life history of Drosophila sperm involves molecular continuity between male and female reproductive tracts

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(11)

Published: March 7, 2022

SignificanceIn species with internal fertilization, sperm spend an important part of their lives within the female. To examine life history during this time, we used semiquantitative proteomics and sex-specific isotopic labeling in fruit flies to determine extent molecular continuity between male female reproductive tracts provide a global catalog sperm-associated proteins. Multiple seminal fluid proteins associate immediately after mating. Few remain long-term storage, whereas female-derived constitute one-fifth postmating proteome by then. Our data reveal "hand-off" from males females, which postulate be component sperm-female interactions.

Language: Английский

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The role of female reproductive fluid in sperm competition

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2020, Volume and Issue: 375(1813), P. 20200077 - 20200077

Published: Oct. 18, 2020

The role of non-gametic components the ejaculate (seminal fluid) in fertility and sperm competitiveness is now well established. Surprisingly, however, we know far less about female reproductive fluid (FRF) context sexual selection, insights into male–FRF interactions competition have only recently emerged. Despite this limited knowledge, evidence from taxonomically diverse species has revealed effects FRF on traits that previously been implicated studies competition. Specifically, through differential a range traits, including chemoattraction alterations velocity, shown to exert positive phenotypic males are preferred as mating partners, or those most compatible genetically males. these tantalizing putative sexually selected functions FRF, largely lack mechanistic understanding processes. Taken together, presented here highlights likely ubiquity FRF-regulated biases fertilization success across taxa, thus potentially elevating importance other so studied This article part theme issue ‘Fifty years competition'.

Language: Английский

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Molecular Diversification of the Seminal Fluid Proteome in a Recently Diverged Passerine Species Pair

Molecular Biology and Evolution, Journal Year: 2019, Volume and Issue: 37(2), P. 488 - 506

Published: Oct. 29, 2019

Seminal fluid proteins (SFPs) mediate an array of postmating reproductive processes that influence fertilization and fertility. As such, it is widely held SFPs may contribute to postmating, prezygotic barriers between closely related taxa. We investigated seminal (SF) diversification in a recently diverged passerine species pair (Passer domesticus Passer hispaniolensis) using combination proteomic comparative evolutionary genomic approaches. First, we characterized compared the SF proteome two species, revealing consistencies with known aspects SFP biology function other taxa, including presence involved immunity sperm maturation. Second, whole-genome resequencing data, assessed patterns differentiation house Spanish sparrows. These analyses detected divergent selection on immunity-related genes positive selective sweeps regions containing number also exhibited protein abundance species. Finally, analyzed molecular evolution across 11 found significantly higher rate rest genome, as well significant enrichments for functional pathways set positively selected genes. Our results suggest important determinant composition evolution. Assessing role speciation taxa should be prioritized given potential incompatibilities

Language: Английский

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How female × male and male × male interactions influence competitive fertilization inDrosophila melanogaster

Evolution Letters, Journal Year: 2020, Volume and Issue: 4(5), P. 416 - 429

Published: Sept. 5, 2020

How males and females contribute to joint reproductive success has been a long-standing question in sexual selection. Under postcopulatory selection, paternity is predicted derive from complex interactions among engaging cryptic female choice sperm competition. Such have identified as potential sources of genetic variation sexually selected traits but are also expected inhibit trait diversification. To date, studies between competing focused almost exclusively on genotypes not phenotypic traits. Here, we characterize within- between-sex Drosophila melanogaster using isogenic lines with heritable both male known influence competitive fertilization. We confirmed, expanded on, previously reported genotypic within the sexes, showed that several events, including transfer, ejection, storage, were explained by two- three-way sex-specific phenotypes. documented lengths males' seminal receptacle, which experienced rapid female-male co-diversification. Our results highlight nonindependence competition demonstrate sexes do limit ability multivariate systems respond directional

Language: Английский

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Sperm and alternative reproductive tactics: a review of existing theory and empirical data

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2020, Volume and Issue: 375(1813), P. 20200075 - 20200075

Published: Oct. 18, 2020

Males that exhibit alternative reproductive tactics (ARTs) often differ in the risk of sperm competition and energetic trade-offs they experience. The resulting patterns selection could lead to between-tactic differences ejaculate traits. Despite extensive research on male ARTs, there is no comprehensive review whether what traits exist between ARTs. We existing theory evolution relevant ARTs then conduct a vote-counting empirical data comparing males adopting general expectation sneaker should produce are more competitive (e.g. higher quality or performance), we find does not predict explicitly how majority studies significant difference performance dominant males. However, when difference, tend have trait values than propose ways future theoretical can improve our understanding highlight studying species with will broader knowledge evolution. This article part theme issue ‘Fifty years competition’.

Language: Английский

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The Physiological and Evolutionary Ecology of Sperm Thermal Performance

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: March 24, 2022

Ongoing anthropogenic climate change has increased attention on the ecological and evolutionary consequences of thermal variation. Most research in this field focused physiology behavior diploid whole organisms. The performance haploid gamete stages directly tied to reproductive success received comparatively little attention, especially context ecology wild (i.e., not domesticated) Here, we review evidence for effects temperature sperm phenotypes, emphasizing data from organisms whenever possible. We find that are pervasive, above normal temperatures particular detrimental. That said, there is traits can evolve adaptively response change, adaptive phenotypic plasticity also place results curves, encourage framework be used as a guide experimental design maximize relevance well comparability across studies. highlight gaps our understanding require more fully understand adaptation global change.

Language: Английский

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Functional Diversity and Evolution of the Drosophila Sperm Proteome

Molecular & Cellular Proteomics, Journal Year: 2022, Volume and Issue: 21(10), P. 100281 - 100281

Published: Aug. 17, 2022

Spermatozoa are central to fertilization and the evolutionary fitness of sexually reproducing organisms. As such, a deeper understanding sperm proteomes (and associated reproductive tissues) has proven critical advancement fields sexual selection biology. Due their extraordinary complexity, proteome depth-of-coverage is dependent on advancements in technology related bioinformatics, both which have made significant decade since last Drosophila was published. Here, we provide an updated version melanogaster (DmSP3) using improved separation detection methods genome annotation. Combined with previous versions proteome, DmSP3 contains total 3176 proteins, first label-free quantitation for 2125 proteins. The top 20 most abundant proteins included structural elements α- β-tubulins leucyl-aminopeptidases. Both gene content protein abundance were significantly reduced X chromosome, consistent prior genomic studies chromosome evolution. We identified 9 16 Y-linked including known testis-specific male fertility factors. also almost one-half ribosomal DmSP3. role this subset unknown. Surprisingly, our expanded 122 seminal fluid (Sfps), originally accessory glands. show that fraction 'sperm-associated Sfps' recalcitrant concentrated salt detergent treatments, suggesting subclass Sfps expressed testes may additional functions sperm, per se. Overall, results add growing landscape biology particular provides quantitative evidence at level findings supporting meiotic sex-chromosome inactivation model male-specific

Language: Английский

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Fertilization mode differentially impacts the evolution of vertebrate sperm components

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 10, 2022

Abstract Environmental change frequently drives morphological diversification, including at the cellular level. Transitions in environment where fertilization occurs (i.e., mode) are hypothesized to be a driver of extreme diversity sperm morphology observed animals. Yet how mode impacts evolution components—head, midpiece, and flagellum—each with different functional roles that must act as an integrated unit remains unclear. Here, we test this hypothesis by examining component lengths across 1103 species vertebrates varying (external vs. internal fertilization). Sperm length is explained part vertebrates, but influences varies among components vertebrate clades. We also identify evolutionary responses not influenced mode: midpieces evolve rapidly both external fertilizers. Fertilization thus through complex component- clade-specific responses.

Language: Английский

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