Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products

Polymers, Journal Year: 2023, Volume and Issue: 15(10), P. 2292 - 2292

Published: May 12, 2023

Natural products have proven their value as drugs that can be therapeutically beneficial in the treatment of various diseases. However, most natural low solubility and poor bioavailability, which pose significant challenges. To solve these issues, several drug nanocarriers been developed. Among methods, dendrimers emerged vectors for due to superior advantages, such a controlled molecular structure, narrow polydispersity index, availability multiple functional groups. This review summarizes current knowledge on structures dendrimer-based compounds, with particular focus applications alkaloids polyphenols. Additionally, it highlights challenges perspectives future development clinical therapy.

Language: Английский

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Targeting the STAT3 pathway with STAT3 degraders

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(9), P. 811 - 823

Published: Aug. 7, 2024

Language: Английский

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Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 2, 2024

Due to the complex pathophysiological mechanisms involved in cancer progression and metastasis, current therapeutic approaches lack efficacy have significant adverse effects. Therefore, it is essential establish novel strategies for combating cancer. Phytochemicals, which possess multiple biological activities, such as antioxidant, anti-inflammatory, antimutagenic, immunomodulatory, antiproliferative, anti-angiogenesis, antimetastatic properties, can regulate interfere various stages of development by suppressing signaling pathways. The systematic comprehensive review was conducted based on Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) criteria, using electronic databases, including PubMed, Scopus, Science Direct, until end December 2023. After excluding unrelated articles, 111 related articles were included this review. In review, major pathways metabolism are highlighted with promising anticancer role phytochemicals. This through their ability AMP-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) pathway. AMPK/PGC-1α pathway plays a crucial cell via targeting energy homeostasis mitochondria biogenesis, glucose oxidation, fatty acid thereby generating ATP growth. As result, may represent approach treatment. Accordingly, alkaloids, phenolic compounds, terpene/terpenoids, miscellaneous phytochemicals been introduced agents regulating Novel delivery systems also

Language: Английский

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Induction mechanisms of autophagy and endoplasmic reticulum stress in intestinal ischemia-reperfusion injury, inflammatory bowel disease, and colorectal cancer

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115984 - 115984

Published: Dec. 8, 2023

In recent years, the incidence of intestinal ischemia-reperfusion injury (II/RI), inflammatory bowel disease (IBD), and colorectal cancer (CRC) has been gradually increasing, posing significant threats to human health. Autophagy endoplasmic reticulum stress (ERS) play important roles in II/RI. Damage caused by ischemia cellular can activate ERS, which turn initiates autophagy clear damaged organelles abnormal proteins, thereby alleviating ERS maintaining environment. IBD, chronic inflammation damages tissues activates ERS. is initiated upregulating ATG genes downregulating factors that inhibit autophagy, clearing organelles, bacteria. Simultaneously, persistent stimulation also trigger leading protein imbalance folding ER lumen. The activation maintain homeostasis initiating process, reducing responses cell apoptosis intestine. CRC, excessive proliferation synthesis lead increased regulated signaling pathways such as IRE1α PERK, initiate proteins negative effects It be seen a crucial regulatory role development diseases. Therefore, progress targeted therapy for diseases based on provides novel strategies managing this paper, we review advances regulation diseases, emphasizing potential molecular mechanisms therapeutic applications.

Language: Английский

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Recognition and Comprehensive Quantitation of Stachydrine Analogues in Leonurus japonicus Based on HILIC-QTOF MS and qHNMR

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Quaternary ammonium salts (QAs) are a class of highly active compounds widely used in medicine and agriculture. However, many QAs lack conjugated system, making their recognition quantitation challenging. Stachydrine is representative unconjugated QA with high content Leonurus japonicus Houtt. (Lamiaceae) serves as quality control compound for the aerial parts L. (LJH). Based on previous studies LJH biosynthetic principles plants, we speculated that series undiscovered stachydrine analogues (STAs) may be present LJH. Using HILIC-QTOF MS technology, this study successfully identified other four STAs besides stachydrine. To further determine total STAs, quantitative 1H NMR (qHNMR) method was established. Notably, effects different concentrations acids bases chemical shifts (δH) accuracy were investigated. Finally, from origins quantified by optimized qHNMR method, it found Zhejiang province higher than provinces. The comprehensive use provides reference rapid QAs.

Language: Английский

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Advance in identified targets of berberine

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, diabetes. Studies have that berberine exhibits polypharmacological effects, antibacterial, anti-inflammatory, antioxidant, hypoglycemic activities. To further elucidate multifaceted pharmacological mechanisms berberine, we reviewed 7 targets identified through co-crystal structure analysis, filamentous temperature-sensitive protein Z (FtsZ), QacR, BmrR, phospholipase A2 (PLA2), RamR, NIMA-related kinase (NEK7), mesenchymal-epithelial transition (MET). Through target fishing, molecular docking, surface plasmon resonance (SPR) analyses, combined with cellular experiments, 6 berberine. These findings provide a comprehensive summary berberine’s direct targets, offering theoretical foundation for exploration its diverse

Language: Английский

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Molecular mechanisms of berberine’s effects on tumor cells

Kazan medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Malignant neoplasms remain one of the leading causes mortality worldwide, underscoring need for development novel and effective therapeutic strategies their treatment. In recent years, scientific community has actively pursued search pharmaceutical preparations with minimal adverse effects high efficacy, capable achieving complete remission in patients. this context, berberine, a natural phytochemical compound derived from various species Berberis, garnered increasing attention due to its diverse pharmacological properties. Berberine, recognized as nutraceutical, exhibits broad spectrum biological activities, including anti-inflammatory, antioxidant, antitumor effects. vitro vivo studies have demonstrated that berberine exerts inhibitory on several types cancer, breast, lung, liver, colorectal cancers. Its properties are associated key molecular mechanisms through which it targets tumor cells. review, we comprehensively examined pathways mediated. Specifically, activates caspase cascade, induction apoptosis cells, inhibits cell proliferation by blocking signaling such PI3K/Akt/mTOR. Additionally, modulates expression genes migration invasion, matrix metalloproteinases E-cadherin, making promising candidate approaches. It is also noteworthy anti-inflammatory properties, may contribute prevention carcinogenesis protecting cells oxidative stress inflammatory processes linked cancer development. These position agent further research clinical application, both monotherapy combination other anticancer drugs. Thus, represents an intriguing subject investigation action potential use oncology, could lead more safer patients malignant neoplasms.

Language: Английский

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Anticancer Potential of Indole Phytoalexins and Their Analogues

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2388 - 2388

Published: May 19, 2024

Indole phytoalexins, found in economically significant Cruciferae family plants, are synthesized response to pathogen attacks or stress, serving as crucial components of plant defense mechanisms against bacterial and fungal infections. Furthermore, recent research indicates that these compounds hold promise for improving human health, particularly terms potential anticancer effects have been observed various studies. Since our last comprehensive overview 2016 focusing on the antiproliferative substances, brassinin camalexin most extensively studied. This review analyses multifaceted pharmacological camalexin, highlighting their potential. In this article, we also provide an activity new synthetic analogs indole which were tested at university with aim enhancing efficacy compared parent compound.

Language: Английский

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Aldo-keto reductases: Role in cancer development and theranostics

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 32(8), P. 1287 - 1308

Published: Jan. 1, 2024

Aldo-keto reductases (AKRs) are a superfamily of enzymes that play crucial roles in various cellular processes, including the metabolism xenobiotics, steroids, and carbohydrates. A growing body evidence has unveiled involvement AKRs development progression cancers. aberrantly expressed wide range malignant tumors. Dysregulated expression enables acquisition hallmark traits cancer by activating oncogenic signaling pathways contributing to chemoresistance. have emerged as promising oncotherapeutic targets given their pivotal role progression. Inhibition aldose reductase (AR), either alone or combination with chemotherapeutic drugs, evolved pragmatic therapeutic option for cancer. Several classes synthetic aldo-keto (AKR) inhibitors been developed potential anticancer agents, some which shown promise clinical trials. Many AKR from natural sources also exhibit effects. Small molecule targeting specific isoforms preclinical studies. These disrupt activation modulating transcription factors kinases sensitizing cells chemotherapy. In this review, we discuss physiological functions human AKRs, aberrant malignancies, hallmarks, signaling, drug resistance. Finally, (ARIs) drugs is summarized.

Language: Английский

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Synergistic Inhibitory Effect of Berberine and Low-Temperature Plasma on Non-Small-Cell Lung Cancer Cells via PI3K-AKT-Driven Signaling Axis

Molecules, Journal Year: 2023, Volume and Issue: 28(23), P. 7797 - 7797

Published: Nov. 27, 2023

Low-temperature plasma (LTP) is an emerging biomedical technique that has been proposed as a potential approach for cancer therapy. Meanwhile, berberine (BER), active ingredient extracted from various medical herbs, such Coptischinesis, proven antitumor effects in broad spectrum of cells. In this study, we seek to develop novel dual therapeutic method by integrating pre-administration BER and LTP exposure evaluating its comprehensive effect on the human non-small-cell lung (NSCLC) cell lines (A549 H1299) vitro. Cell viability, cycle, apoptosis, intracellular extracellular ROS were investigated. The results showed cotreatment significantly decreased arrested cycle S phase, promoted increased ROS. Additionally, RNA Sequencing (RNA-Seq) technology was used explore mechanisms. differentially expressed genes among different treatment groups NSCLC cells analyzed mainly enriched phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. Moreover, notably depressed total protein expression level PI3K AKT with immunoblotting. conclusion, have synergistic inhibitory via PI3K-AKT pathway, which could provide promising strategy supplementary therapy anti-NSCLC battle.

Language: Английский

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