Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 39, P. 101752 - 101752
Published: June 1, 2024
Language: Английский
Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0322708 - e0322708
Published: May 14, 2025
Background Alzheimer’s disease (AD) is an irreversible neurodegenerative brain disorder, and autophagy crafts a new dawn on AD therapeutics. However, whether LINC00672 exerts its biological effects involvement in autophagy-mediated mechanisms remain obscure. Methods SH-SY5Y cells were treated with Amyloid Beta 1–42 (Aβ1-42, Aβ), while mouse model was established using streptozotocin (STZ). The of overexpression cell proliferation, apoptosis, evaluated Aβ-stimulated cells. Besides, the impact cognitive function pathological changes hippocampal tissues validated mice. Additionally, interaction between GPNMB silencing determined vitro. Results Aβ stimulation diminished viability, augmented restricted activation cells, these alterations partially abolished by overexpression. Furthermore, upregulation could improve impairment, attenuate neuronal damage even death STZ-treated knockdown aggravated improved injury relatively restrained after Conclusions exerted protective effect progression upregulating to promote autophagy.
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: July 19, 2024
Vacuole membrane protein 1 (VMP1) is an integral that plays a pivotal role in cellular processes, particularly the regulation of autophagy. Autophagy, self-degradative mechanism, essential for maintaining homeostasis by degradation and recycling damaged organelles proteins. VMP1 involved autophagic processes include formation autophagosomes subsequent fusion with lysosomes. Moreover, modulates endoplasmic reticulum (ER) calcium levels, which significant various functions, including folding signaling. Recent studies have also linked to response against viral infections lipid droplet (LD). Dysregulation has been observed several pathological conditions, neurodegenerative diseases such as Parkinson's disease (PD), pancreatitis, hepatitis, tumorogenesis, underscoring its potential therapeutic target. This review aims provide overview VMP1's multifaceted roles implications pathology.
Language: Английский
Citations
2
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118785 - 118785
Published: Sept. 4, 2024
Language: Английский
Citations
2
Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36470 - e36470
Published: Aug. 17, 2024
Alzheimer's disease (AD) is a neurological with memory loss and cognitive decline, which affects large proportion of the aging population. Regrettably, there are no drug to reverse or cure AD development for primary theory amyloid beta deposition has mostly failed. Therefore, an urgent need investigate novel strategies preventing AD. Recent studies demonstrate that imbalance mitochondrial homeostasis driver in Aβ accumulation, can lead occurrence deterioration impairment patients. This suggests regulating neuronal may be new strategy We summarize importance neuron its regulatory mechanisms this review. In addition, we results indicating dysfunction subjects, including impaired energy production, oxidative stress, protein homeostasis, fusion fission, biogenesis autophagy, altered motility, hope providing possible therapeutic approaches
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10829 - 10829
Published: Oct. 9, 2024
Abnormal protein accumulations in the brain are linked to aging and pathogenesis of dementia various types, including Alzheimer’s disease. These can be reduced by cell indigenous mechanisms. Among these is autophagy, whereby proteins transferred lysosomes for degradation. Autophagic dysfunction hampers elimination pathogenic aggregations that contribute death. We had observed adhesion molecule L1 interacts with microtubule-associated 1 light-chain 3 (LC3), which needed autophagy substrate selection. increases survival an LC3-dependent manner via its extracellular LC3 interacting region (LIR). also Aβ reduces plaque load AD model mouse. Based on results, we investigated whether could aggregated clearance. here show autophagy-related 12 (ATG12) LIR domain, whereas interaction ubiquitin-binding p62/SQSTM1 does not depend LIR. Aβ, bound L1, carried autophagosome leading elimination. Showing mitophagy-related L1-70 fragment ubiquitinated, expect pathway contributes propose enhancing functions may therapy humans.
Language: Английский
Citations
1
Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 39, P. 101752 - 101752
Published: June 1, 2024
Language: Английский
Citations
0