Cited by Brusatol improves the efficacy of sorafenib in Huh7 cells via ferroptosis resistance dependent Nrf2 signaling pathway

Targeting cell death mechanisms: the potential of autophagy and ferroptosis in hepatocellular carcinoma therapy DOI

Beibei Liu,

Ling Liu,

Yang Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 9, 2024

Ferroptosis is a type of cell death that plays remarkable role in the growth and advancement malignancies including hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) have considerable impact on HCC by functioning as either oncogenes or suppressors. Recent research has demonstrated non-coding ability to control ferroptosis cells, hence impacting tumors resistance these cells drugs. Autophagy mechanism conserved throughout evolution maintaining balance body under normal settings. Nevertheless, occurrence dysregulation autophagy evident progression various human disorders, specifically cancer. dual roles cancer, potentially influencing both survival death. prevalent kind liver genetic mutations changes molecular pathways might worsen its advancement. The subject debate, it capacity repress promote tumor growth. activation can apoptosis, proliferation glucose metabolism, facilitate spread through EMT. Inhibiting hinder enhance respond treatment. regulated several signaling pathways, such STAT3, Wnt, miRNAs, lncRNAs, circRNAs. Utilizing anticancer drugs target may advantageous implications for efficacy cancer

Language: Английский

Citations

Brusatol Inhibits the Viability of Anaplastic Thyroid Carcinoma Cells by Modulating the JAK1/STAT3 Signaling Pathway DOI

C. Zhang,

Runbo Xie, Yuchen Gao

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Brusatol inhibits malignant phenotypes and lipid metabolism of osteosarcoma cells by regulating PI3K/AKT and MAPK pathways DOI

Xuhui Yuan,

Sun‐Kyoung Yu, Lan Lin

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156464 - 156464

Published: Feb. 12, 2025

Language: Английский

Citations

The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside DOI

Xin Jin,

C. Huang,

Yue Tian

et al.

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 3, 2024

Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.

Language: Английский

Citations

ATF family members as therapeutic targets in cancer: From mechanisms to pharmacological interventions DOI

Xueyao Zhang,

Zhijia Li, Xiaochun Zhang

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107355 - 107355

Published: Aug. 22, 2024

The activating transcription factor (ATF)/ cAMP-response element binding protein (CREB) family represents a large group of basic zone leucine zip (bZIP) factors (TFs) with variety physiological functions, such as endoplasmic reticulum (ER) stress, amino acid heat oxidative integrated stress response (ISR) and thus inducing cell survival or apoptosis. Interestingly, ATF has been increasingly implicated in autophagy ferroptosis recent years. Thus, the is important for homeostasis its dysregulation may promote disease progression including cancer. Current therapeutic approaches to modulate include direct modulators, upstream post-translational modifications (PTMs) modulators. This review summarizes structural domain PTMs feature ATF/CREB comprehensively explores molecular regulatory mechanisms. On this basis, their pathways affecting proliferation, metastasis, drug resistance various types cancer cells are sorted out discussed. We then systematically summarize status applications existing modulators finally look forward future prospect clinical treatment tumors by modulating family.

Language: Английский

Citations

Brusatol improves the efficacy of sorafenib in Huh7 cells via ferroptosis resistance dependent Nrf2 signaling pathway DOI

Xujin Liu,

Tianyi Liu,

Zhonghua Zhou

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150762 - 150762

Published: Sept. 27, 2024

Language: Английский

Citations