The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response DOI Creative Commons
Liqian Zhu, Clinton Jones, Gaiping Zhang

et al.

Journal of Immunology Research, Journal Year: 2018, Volume and Issue: 2018, P. 1 - 9

Published: Jan. 1, 2018

Macrophages are crucial members of the mononuclear phagocyte system essential to protect host from invading pathogens and central inflammatory response with their ability acquire specialized phenotypes (M1) anti-inflammatory (M2) produce a pool mediators. Equipped broad range receptors, such as Toll-like receptor 4 (TLR4), CD14, Fc gamma receptors (Fc γ Rs), macrophages can efficiently recognize phagocytize secrete cytokines by triggering various secondary signaling pathways. Phospholipase C (PLC) is family enzymes that hydrolyze phospholipids, most significant which phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. Cleavage at internal phosphate ester generates two second messengers, inositol 1,4,5-trisphosphate (IP3) diacylglycerol (DAG), both mediate in diverse cellular functions including response. Recent studies have shown some PLC isoforms involved multiple stages TLR4-, CD14-, Rs-mediated activation nuclear factor kappa B (NF- κ B), mitogen-activated protein kinase (MAPK), interferon regulatory factors (IRFs), all associated regulation Therefore, implicated pathogenesis numerous diseases. This review provides an overview our current knowledge on how regulates macrophage-mediated

Language: Английский

Mesenchymal Stem Cell-Macrophage Crosstalk and Maintenance of Inflammatory Microenvironment Homeostasis DOI Creative Commons
Di Lu, Yan Xu, Qiuli Liu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: June 25, 2021

Macrophages are involved in almost every aspect of biological systems and include development, homeostasis repair. Mesenchymal stem cells (MSCs) have good clinical application prospects due to their ability regulate adaptive innate immune cells, particularly macrophages, they been used successfully for many disorders, including inflammatory bowel disease (IBD), acute lung injury, wound healing, which reported as macrophage-mediated disorders. In the present review, we focus on interaction between MSCs macrophages summarize methods communication, such cell-to-cell contact, soluble factor secretion, organelle transfer. addition, discuss roles MSC-macrophage crosstalk development maintenance microenvironments. Finally, provide optimal strategies applications immune-related treatments.

Language: Английский

Citations

97
The Dynamic Interplay Between Cardiac Inflammation and Fibrosis DOI Creative Commons

Toby P. Thomas,

Laurel A. Grisanti

Frontiers in Physiology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 15, 2020

Heart failure is a leading cause of death worldwide. While there are multiple etiologies contributing to the development heart failure, all result in impairments cardiac function that characterized by changes remodeling and compliance. Fibrosis associated with nearly forms an important contributor disease pathogenesis. Inflammation also plays critical role large degree interconnectedness between inflammatory fibrotic response. This review discusses cellular molecular mechanisms inflammation fibrosis interplay two.

Language: Английский

Citations

89
Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels DOI Creative Commons
Long You,

Seunghwa Cha,

Mi‐Yeon Kim

et al.

Journal of Ginseng Research, Journal Year: 2021, Volume and Issue: 46(6), P. 711 - 721

Published: Dec. 22, 2021

The immune system is one of the most important parts human body and immunomodulation major function system. In response to outside pathogens or high inflammation, stimulated suppressed. Thus, identifying effective potent immunostimulants immunosuppressants critical. Ginsenosides are a type steroid saponin derived from ginseng. Most harmless even have tonic effects. this review, we mainly focus on immunostimulatory immunosuppressive roles two types ginsenosides: protopanaxadiol (PPD)-type protopanaxatriol (PPT)-type. PPT-type ginsenosides include Rg1, Rg2, Rh4, Re notoginsenoside R1, PPD-type Rg3, Rh2, Rb1, Rb2, Rc, Rd, compound K (CK) PPD, which activate responses. addition, Rg1 Rg6 belong together with CK show properties. Current explorations in immunological areas preliminary stages. Therefore, review may provide some novel ideas researchers who study immunoregulatory ginsenosides.

Language: Английский

Citations

72
Immunogenicity Challenges Associated with Subcutaneous Delivery of Therapeutic Proteins DOI Open Access
Nicole L. Jarvi, Sathy V. Balu‐Iyer

BioDrugs, Journal Year: 2021, Volume and Issue: 35(2), P. 125 - 146

Published: Feb. 1, 2021

Language: Английский

Citations

69
Macrophages in heterotopic ossification: from mechanisms to therapy DOI Creative Commons
Yifei Huang, Xinyi Wang,

Daixuan Zhou

et al.

npj Regenerative Medicine, Journal Year: 2021, Volume and Issue: 6(1)

Published: Oct. 26, 2021

Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It caused by an injury that stimulates abnormal tissue healing and regeneration, inflammation involved this process. worth noting macrophages are crucial mediators inflammation. In regard, abundant recruited to HO site contribute progression. Macrophages can acquire different functional phenotypes promote mesenchymal stem cell (MSC) osteogenic differentiation, chondrogenic angiogenesis expressing cytokines other factors such as transforming growth factor-β1 (TGF-β1), morphogenetic protein (BMP), activin A (Act A), oncostatin M (OSM), substance P (SP), neurotrophin-3 (NT-3), vascular endothelial factor (VEGF). addition, significantly hypoxic microenvironment, which primarily drives Thus, these have led interest role exploring whether a "butterfly effect" event. Heterogeneous regarded "butterflies" drive sequence events ultimately HO. review, we discuss how recruitment contributes particular, review molecular mechanisms through participate MSC angiogenesis, microenvironment. Understanding diverse may unveil potential targets for prevention treatment

Language: Английский

Citations

61
Innate Immune Memory and the Host Response to Infection DOI Open Access
Edward R. Sherwood,

Katherine R. Burelbach,

Margaret A. McBride

et al.

The Journal of Immunology, Journal Year: 2022, Volume and Issue: 208(4), P. 785 - 792

Published: Feb. 3, 2022

Abstract Unlike the adaptive immune system, innate system has classically been characterized as being devoid of memory functions. However, recent research shows that myeloid and lymphoid cells have ability to retain prior pathogen exposure become primed elicit a robust, broad-spectrum response subsequent infection. This phenomenon termed or trained immunity. Innate is induced via activation pattern recognition receptors actions cytokines on hematopoietic progenitors stem in bone marrow leukocytes periphery. The phenotype sustained epigenetic modifications reprogram transcriptional patterns metabolism. These augment antimicrobial functions, such leukocyte expansion, chemotaxis, phagocytosis, microbial killing, facilitate an augmented host Alternatively, may contribute pathogenesis chronic diseases, atherosclerosis Alzheimer’s disease.

Language: Английский

Citations

61
The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) Cell and Macrophage (CAR-M) Therapy against Breast Cancer DOI Open Access
Giuseppe Schepisi, Caterina Gianni, Michela Palleschi

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(5), P. 1597 - 1597

Published: March 4, 2023

Breast cancer represents one of the most common tumor histologies. To date, based on specific histotype, different therapeutic strategies, including immunotherapies, capable prolonging survival are used. More recently, astonishing results that were obtained from CAR-T cell therapy in haematological neoplasms led to application this new strategy solid tumors as well. Our article will deal with chimeric antigen receptor-based immunotherapy (CAR-T and CAR-M therapy) breast cancer.

Language: Английский

Citations

31
Efficacy evaluation of chimeric antigen receptor-modified human peritoneal macrophages in the treatment of gastric cancer DOI Creative Commons
Xuhui Dong,

Jiqiang Fan,

Wangxu Xie

et al.

British Journal of Cancer, Journal Year: 2023, Volume and Issue: 129(3), P. 551 - 562

Published: June 29, 2023

Abstract Background Gastric cancer is one of the most common cancers. Peritoneal carcinomatosis (PC) appears to be pattern recurrence, and more than half GC patients eventually die from PC. Novel strategies for management with PC are urgently needed. Recently, rapid progress has been made in adoptive transfer therapy by using macrophages as effector cells due their capabilities phagocytosis, antigen presentation, high penetration. Here, we generated a novel macrophage-based investigated anti-tumoral effects on potential toxicity. Methods We developed Chimeric Antigen Receptor-Macrophage (CAR-M) based genetically modifying human peritoneal (PMs), expressing HER2-FcεR1γ-CAR (HF-CAR). tested HF-CAR variety models vitro vivo. Results HF-CAR-PMs specifically targeted HER2-expressed GC, harboured FcεR1γ moieties trigger engulfment. Intraperitoneal administration significantly facilitated HER2-positive tumour regression mouse model prolonged overall survival rate. In addition, combined use oxaliplatin exhibited augment anti-tumour activity benefit. Conclusions could represent an exciting therapeutic option cancer, which should carefully designed clinical trials.

Language: Английский

Citations

30
Anti-Tumor Strategies by Harnessing the Phagocytosis of Macrophages DOI Open Access
Siyuan Li,

Yong-Lin Guo,

Jia-Wen Tian

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(10), P. 2717 - 2717

Published: May 11, 2023

Macrophages are essential for the human body in both physiological and pathological conditions, engulfing undesirable substances participating several processes, such as organism growth, immune regulation, maintenance of homeostasis. play an important role anti-bacterial anti-tumoral responses. Aberrance phagocytosis macrophages may lead to development diseases, including tumors. Tumor cells can evade macrophages, "educate" become pro-tumoral, resulting reduced macrophages. Hence, harnessing is approach bolster efficacy anti-tumor treatment. In this review, we elucidated underlying mechanisms, equilibrium among phagocytic signals, receptors their respective signaling pathways, macrophage activation, well mitochondrial fission. We also reviewed recent progress area application strategies on basis mechanism, targeting antibody-dependent cellular (ADCP), activators. covered studies Chimeric Antigen Receptor Macrophage (CAR-M)-based therapy. Furthermore, summarized shortcomings future applications each strategy look into prospects with hope providing research directions developing phagocytosis-promoting

Language: Английский

Citations

26
New cell sources for CAR-based immunotherapy DOI Creative Commons
Marzieh Mazinani, Fatemeh Rahbarizadeh

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: May 6, 2023

Chimeric antigen receptor (CAR) T cell therapy, in which a patient's own lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success some hematological malignancies preclinical clinical trials, resulting six FDA-approved CAR-T products currently available the market. Despite impressive outcomes, concerns about treatment failure associated with low efficacy or high cytotoxicity of cells remain. While main focus been on improving exploring alternative cellular sources for CAR generation garnered growing interest. In current review, we comprehensively evaluated other rather than conventional generation.

Language: Английский

Citations

25