Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
14
Published: April 26, 2023
Microglia,
characterized
by
responding
to
damage,
regulating
the
secretion
of
soluble
inflammatory
mediators,
and
engulfing
specific
segments
in
central
nervous
system
(CNS),
function
as
key
immune
cells
CNS.
Emerging
evidence
suggests
that
microglia
coordinate
responses
CNS
play
a
pivotal
role
pathogenesis
age-related
neurodegenerative
diseases
(NDDs).
Remarkably,
autophagy
participates
regulation
subcellular
substances,
which
includes
degradation
misfolded
proteins
other
harmful
constituents
produced
neurons.
Therefore,
regulates
neuronal
homeostasis
maintenance
process
neuroinflammation.
In
this
review,
we
aimed
at
highlighting
NDDs.
Besides
mechanistic
co-interaction
between
different
kinds
NDDs,
also
emphasized
potential
therapeutic
agents
approaches
could
be
utilized
onset
progression
these
through
modulating
autophagy,
including
promising
nanomedicines.
Our
review
provides
valuable
reference
for
subsequent
studies
focusing
on
treatments
disorders.
The
exploration
development
nanomedicines
greatly
enhances
current
understanding
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117092 - 117092
Published: July 7, 2024
Sepsis-associated
encephalopathy
(SAE)
is
a
disease
characterized
by
neuroinflammation
and
cognitive
dysfunction
caused
systemic
infection.
Inflammation-induced
microglial
activation
closely
associated
with
in
SAE.
It
widely
understood
that
melatonin
has
strong
anti-inflammatory
immunomodulatory
properties
beneficial
for
sepsis-related
brain
damage.
However,
the
mechanism
of
action
SAE
not
been
fully
elucidated.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3648 - 3648
Published: March 25, 2024
In
this
study,
binary
amorphous
solid
dispersions
(ASDs,
fisetin-Eudragit®)
and
ternary
inclusions
(ASIs,
fisetin-Eudragit®-HP-β-cyclodextrin)
of
fisetin
(FIS)
were
prepared
by
the
mechanochemical
method
without
solvent.
The
nature
FIS
in
ASDs
ASIs
was
confirmed
using
XRPD
(X-ray
powder
diffraction).
DSC
(Differential
scanning
calorimetry)
full
miscibility
multicomponent
delivery
systems.
FT-IR
(Fourier-transform
infrared
analysis)
interactions
that
stabilize
FIS's
state
identified
functional
groups
involved.
study
culminated
evaluating
impact
amorphization
on
water
solubility
conducting
vitro
antioxidant
assays:
2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)-ABTS,
2,2-diphenyl-1-picrylhydrazyl-DPPH,
Cupric
Reducing
Antioxidant
Capacity-CUPRAC,
Ferric
Power-FRAP
neuroprotective
inhibition
acetylcholinesterase-AChE
butyrylcholinesterase-BChE.
addition,
molecular
docking
allowed
for
determination
possible
bonds
between
mentioned
above
enzymes.
best
preparation
turned
out
to
be
ASI_30_EPO
(ASD
fisetin-Eudragit®
containing
30%
combination
with
HP-β-cyclodextrin),
which
showed
an
improvement
apparent
(126.5
±
0.1
µg∙mL-1)
properties
(ABTS:
IC50
=
10.25
µg∙mL-1,
DPPH:
27.69
CUPRAC:
IC0.5
9.52
FRAP:
8.56
(inhibition
AChE:
39.91%,
BChE:
42.62%).
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
14
Published: April 26, 2023
Microglia,
characterized
by
responding
to
damage,
regulating
the
secretion
of
soluble
inflammatory
mediators,
and
engulfing
specific
segments
in
central
nervous
system
(CNS),
function
as
key
immune
cells
CNS.
Emerging
evidence
suggests
that
microglia
coordinate
responses
CNS
play
a
pivotal
role
pathogenesis
age-related
neurodegenerative
diseases
(NDDs).
Remarkably,
autophagy
participates
regulation
subcellular
substances,
which
includes
degradation
misfolded
proteins
other
harmful
constituents
produced
neurons.
Therefore,
regulates
neuronal
homeostasis
maintenance
process
neuroinflammation.
In
this
review,
we
aimed
at
highlighting
NDDs.
Besides
mechanistic
co-interaction
between
different
kinds
NDDs,
also
emphasized
potential
therapeutic
agents
approaches
could
be
utilized
onset
progression
these
through
modulating
autophagy,
including
promising
nanomedicines.
Our
review
provides
valuable
reference
for
subsequent
studies
focusing
on
treatments
disorders.
The
exploration
development
nanomedicines
greatly
enhances
current
understanding
