Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity DOI Open Access
Natalia Rosiak, Ewa Tykarska, Judyta Cielecka‐Piontek

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3648 - 3648

Опубликована: Март 25, 2024

In this study, binary amorphous solid dispersions (ASDs, fisetin-Eudragit®) and ternary inclusions (ASIs, fisetin-Eudragit®-HP-β-cyclodextrin) of fisetin (FIS) were prepared by the mechanochemical method without solvent. The nature FIS in ASDs ASIs was confirmed using XRPD (X-ray powder diffraction). DSC (Differential scanning calorimetry) full miscibility multicomponent delivery systems. FT-IR (Fourier-transform infrared analysis) interactions that stabilize FIS's state identified functional groups involved. study culminated evaluating impact amorphization on water solubility conducting vitro antioxidant assays: 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)-ABTS, 2,2-diphenyl-1-picrylhydrazyl-DPPH, Cupric Reducing Antioxidant Capacity-CUPRAC, Ferric Power-FRAP neuroprotective inhibition acetylcholinesterase-AChE butyrylcholinesterase-BChE. addition, molecular docking allowed for determination possible bonds between mentioned above enzymes. best preparation turned out to be ASI_30_EPO (ASD fisetin-Eudragit® containing 30% combination with HP-β-cyclodextrin), which showed an improvement apparent (126.5 ± 0.1 µg∙mL-1) properties (ABTS: IC50 = 10.25 µg∙mL-1, DPPH: 27.69 CUPRAC: IC0.5 9.52 FRAP: 8.56 (inhibition AChE: 39.91%, BChE: 42.62%).

Язык: Английский

The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review DOI

Yizhen Jiang,

Xiangwen Tang,

Peng Deng

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 60(11), С. 6383 - 6394

Опубликована: Июль 15, 2023

Язык: Английский

Процитировано

15
Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS/TNF-α-NLRP3 inflammasomes pathway DOI

Sagar Mahawar,

Debarati Rakshit,

Inklisan Patel

и другие.

Nanomedicine Nanotechnology Biology and Medicine, Год журнала: 2024, Номер 59, С. 102752 - 102752

Опубликована: Май 12, 2024

Язык: Английский

Процитировано

6
Melatonin regulates microglial M1/M2 polarization via AMPKα2-mediated mitophagy in attenuating sepsis-associated encephalopathy DOI Open Access
Yang Yang,

Jinyong Ke,

Yang Cao

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 117092 - 117092

Опубликована: Июль 7, 2024

Sepsis-associated encephalopathy (SAE) is a disease characterized by neuroinflammation and cognitive dysfunction caused systemic infection. Inflammation-induced microglial activation closely associated with in SAE. It widely understood that melatonin has strong anti-inflammatory immunomodulatory properties beneficial for sepsis-related brain damage. However, the mechanism of action SAE not been fully elucidated.

Язык: Английский

Процитировано

6
Role of microglia autophagy and mitophagy in age-related neurodegenerative diseases DOI Creative Commons
Mingkai Lin, Hongwen Yu,

Qiuyan Xie

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 14

Опубликована: Апрель 26, 2023

Microglia, characterized by responding to damage, regulating the secretion of soluble inflammatory mediators, and engulfing specific segments in central nervous system (CNS), function as key immune cells CNS. Emerging evidence suggests that microglia coordinate responses CNS play a pivotal role pathogenesis age-related neurodegenerative diseases (NDDs). Remarkably, autophagy participates regulation subcellular substances, which includes degradation misfolded proteins other harmful constituents produced neurons. Therefore, regulates neuronal homeostasis maintenance process neuroinflammation. In this review, we aimed at highlighting NDDs. Besides mechanistic co-interaction between different kinds NDDs, also emphasized potential therapeutic agents approaches could be utilized onset progression these through modulating autophagy, including promising nanomedicines. Our review provides valuable reference for subsequent studies focusing on treatments disorders. The exploration development nanomedicines greatly enhances current understanding

Язык: Английский

Процитировано

13
Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity DOI Open Access
Natalia Rosiak, Ewa Tykarska, Judyta Cielecka‐Piontek

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3648 - 3648

Опубликована: Март 25, 2024

In this study, binary amorphous solid dispersions (ASDs, fisetin-Eudragit®) and ternary inclusions (ASIs, fisetin-Eudragit®-HP-β-cyclodextrin) of fisetin (FIS) were prepared by the mechanochemical method without solvent. The nature FIS in ASDs ASIs was confirmed using XRPD (X-ray powder diffraction). DSC (Differential scanning calorimetry) full miscibility multicomponent delivery systems. FT-IR (Fourier-transform infrared analysis) interactions that stabilize FIS's state identified functional groups involved. study culminated evaluating impact amorphization on water solubility conducting vitro antioxidant assays: 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)-ABTS, 2,2-diphenyl-1-picrylhydrazyl-DPPH, Cupric Reducing Antioxidant Capacity-CUPRAC, Ferric Power-FRAP neuroprotective inhibition acetylcholinesterase-AChE butyrylcholinesterase-BChE. addition, molecular docking allowed for determination possible bonds between mentioned above enzymes. best preparation turned out to be ASI_30_EPO (ASD fisetin-Eudragit® containing 30% combination with HP-β-cyclodextrin), which showed an improvement apparent (126.5 ± 0.1 µg∙mL-1) properties (ABTS: IC50 = 10.25 µg∙mL-1, DPPH: 27.69 CUPRAC: IC0.5 9.52 FRAP: 8.56 (inhibition AChE: 39.91%, BChE: 42.62%).

Язык: Английский

Процитировано

5