Gut microbiota in brain tumors: An emerging crucial player

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 29(S1), P. 84 - 97

Published: Jan. 10, 2023

In recent decades, various roles of the gut microbiota in physiological and pathological conditions have been uncovered. Among many interacting pathways between host flora, gut-brain axis has drawn increasing attention is generally considered a promising way to understand treat brain tumors, one most lethal neoplasms. this narrative review, we aimed unveil dissect sophisticated mechanisms by which exerts its influence on tumors. Furthermore, summarized latest research regarding gastrointestinal microbial landscape effect malfunction different Finally, outlined ongoing developing approaches manipulation their corresponding related neuro-malignancies. Collectively, recapitulated advances alterations along with potential interactive tumors encouraged increased efforts area.

Language: Английский

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Radiotherapy of high-grade gliomas: dealing with a stalemate

Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 190, P. 104110 - 104110

Published: Aug. 30, 2023

Language: Английский

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Glioblastoma: molecular features, emerging molecular targets and novel therapeutic strategies

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104764 - 104764

Published: May 1, 2025

Language: Английский

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Circadian rhythm related genes signature in glioma for drug resistance prediction: a comprehensive analysis integrating transcriptomics and machine learning

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 5, 2025

Gliomas, 24% of all primary brain tumors, have diverse histology and poor survival rates, with about 70% recurring due to acquired or de novo resistance. Insomnia in patients is correlated strongly circadian rhythm disruptions. The correlation between disorders drug resistance some tumors has been proved. However, the precise mechanism underlying relationship glioma not elucidated. Circadian rhythm-related genes (CRRGs) were identified using least absolute shrinkage selection operator (LASSO) regression, stochastic gradient descent (SGD) was performed form a score (CRRS) model. studies immune cell infiltration, genetic variations, differential gene expression pattern, single analysis for exploring mechanisms chemotherapy glioma. CRRGs chemosensitivity also confirmed by IC 50 (half maximal inhibitory concentration) analysis. Signatures 16 screened out identified. Based on CRRS model, an optimal comprehensive nomogram created, exhibiting favorable potential predicting samples. Immune cell–cell communication, indicated that high group closely related innate cells. IC50 showed CRRG knockdown enhanced A significant CRRGs, glioma, cells found, which might hold role

Language: Английский

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Unravelling the link between circadian clock genes and brain tumors: From pathological disruptions to potential therapeutic interventions

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 27, 2025

The circadian clock is present in nearly all tissues (including glial cells), which play crucial roles brain functions and development. Circadian genes (CCGs) are responsible for regulating numerous cancer-associated biological mechanisms, including the regulation of cell cycle genes, apoptosis, proliferation. A range studies have already confirmed potential link between tumors CCGs, Bmal1, Clock, Period 1, 2, 3, Cry1, Cry2, retinoid-related orphan receptor-α (ROR-α). Growing evidence regarding gliomas glioblastoma multiforme (GBM) indicates significance modulation CCG cancer biology. Various revealed how tumor cells can disrupt CCGs to safeguard their survival. It has also recently been demonstrated case (especially GBM) that should be targeted development novel therapies or ameliorate current treatments impair abolish growth. Multiple pharmacological modulators reported as effective tumors, such temozolomide, inhibitors casein kinase 1 curcumin, norepinephrine, melatonin, REV-ERB agonists, agonists retinoic acid-related receptor, cryptochrome protein stabilizers, 1A-116. In this review, an overview genetics clock, pathological disruptions discussed. addition, interventions modulate reviewed.

Language: Английский

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Insights about circadian clock in glioma: From molecular pathways to therapeutic drugs

CNS Neuroscience & Therapeutics, Journal Year: 2022, Volume and Issue: 28(12), P. 1930 - 1941

Published: Sept. 6, 2022

Abstract Glioma is characterized as the most aggressive brain tumor that occurred in central nervous system. The circadian rhythm an essential cyclic change system generated by endogenous clock. Current studies found clock affects glioma pathophysiology. It still controversial whether disruption a cause or effect of tumorigenesis. This review discussed association between cell cycle and provided prominent molecular theoretical basis for therapy. We illustrated external factors affecting including thermodynamics, hypoxia, post‐translation, microRNA, while internal characteristics concerning involve stemness, metabolism, radiotherapy sensitivity, chemotherapy sensitivity. also summarized pathways therapeutic drugs involved rhythm. There are many questions this field waiting further investigation. results chronotherapy sensitizing radiation therapy have shown great potential improving clinical outcomes. These findings will help us understand

Language: Английский

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Green synthesis of metal nanocarriers: a perspective for targeting glioblastoma

Drug Discovery Today, Journal Year: 2024, Volume and Issue: unknown, P. 104219 - 104219

Published: Oct. 1, 2024

Language: Английский

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Development and validation of a nomogram to predict overall survival in patients with glioma: a population-based study

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

The objective is to investigate the prognostic factors associated with gliomas and develop assess a predictive nomogram model connected survival that may serve as an additional resource for clinical management of glioma patients.

Language: Английский

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Overview on Common Genes Involved in the Onset of Glioma and on the Role of Migraine as Risk Factor: Predictive Biomarkers or Therapeutic Targets?

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(12), P. 1969 - 1969

Published: Nov. 28, 2022

Gliomas are relatively rare but fatal cancers, and there has been insufficient research to specifically evaluate the role of headache as a risk factor. Nowadays, gliomas difficult cure due infiltrative nature absence specific adjuvant therapies. Until now, mutations in hundreds genes have identified most relevant discoveries showed alterations related migraine potential factors for brain tumor onset. Prognostic biomarkers required at time diagnosis better adapt therapies cancer patients. In this review, we aimed highlight significant modulation CLOCK, BMLA1 NOTCH glioma onset development, praising these be good potentially attractive therapeutic markers tumors. A improved knowledge regarding triggering or modulating maybe key early diagnosing patients affected by simple headache. addition, investigating on can suggest targets treating These considerations open up possibility personalized treatments that target each tumor’s genetic abnormality.

Language: Английский

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Quantum Biology of Circadian Rhythms

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 101 - 117

Published: Jan. 1, 2023

Language: Английский

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