Magnetic Resonance in Medical Sciences,
Journal Year:
2024,
Volume and Issue:
23(3), P. 268 - 290
Published: Jan. 1, 2024
More
than
5
years
have
passed
since
the
Diffusion
Tensor
Image
Analysis
ALong
Perivascular
Space
(DTI-ALPS)
method
was
proposed
with
intention
of
evaluating
glymphatic
system.
This
is
handy
due
to
its
noninvasiveness,
provision
a
simple
index
in
straightforward
formula,
and
possibility
retrospective
analysis.
Therefore,
ALPS
adopted
evaluate
system
for
many
disorders
studies.
The
purpose
this
review
look
back
discuss
at
moment.
Neurobiology of Disease,
Journal Year:
2025,
Volume and Issue:
205, P. 106791 - 106791
Published: Jan. 6, 2025
Neurodegenerative
diseases
(ND)
are
characterized
by
the
accumulation
of
aggregated
proteins.
The
glymphatic
system,
through
its
rapid
exchange
mechanisms
between
cerebrospinal
fluid
(CSF)
and
interstitial
(ISF),
facilitates
movement
metabolic
substances
within
brain,
serving
functions
akin
to
those
peripheral
lymphatic
system.
This
emerging
waste
clearance
mechanism
offers
a
novel
perspective
on
removal
pathological
in
ND.
article
elucidates
recent
discoveries
regarding
system
updates
relevant
concepts
model.
It
discusses
potential
roles
ND,
including
Alzheimer's
disease
(AD),
Parkinson's
(PD),
multiple
atrophy
(MSA),
proposes
as
therapeutic
target
for
these
conditions.
CNS Neuroscience & Therapeutics,
Journal Year:
2022,
Volume and Issue:
29(1), P. 111 - 121
Published: Oct. 2, 2022
The
aim
of
the
study
was
to
evaluate
glymphatic
function
and
its
related
factors
in
patients
with
Parkinson's
disease
(PD)
PD
different
ages
using
diffusion
tensor
image
analysis
along
perivascular
space
(DTI-ALPS)
method.Medical
records
imaging
data
93
idiopathic
42
age-
sex-matched
healthy
controls
(HCs)
were
retrospectively
reviewed
analyzed.
diffusivity
spaces,
projection
fibers,
association
fibers
calculated
on
(DTI)
acquire
(ALPS)
index.PD
exhibited
a
reduced
ALPS
index
compared
HCs.
Negative
correlations
between
clinical
information
including
age,
age
at
onset,
sleep
scale
2nd
version
(PDSS-2)
scores,
history
diabetes
mellitus
revealed
group.
Besides,
negative
correlation
severity
motor
symptoms
identified
subgroup
aged
65
above,
rather
than
younger
ones.The
results
demonstrate
that
index,
potential
noninvasive
measure
compromised
activity,
is
involved
pathophysiology
PD,
especially
ones
those
disorders.
Brain,
Journal Year:
2023,
Volume and Issue:
147(1), P. 100 - 108
Published: Aug. 16, 2023
Abstract
Recently,
an
astrocytic
aquaporin
4-dependent
drainage
system,
that
is,
the
glymphatic
has
been
identified
in
live
murine
and
human
brain.
Growing
evidence
suggests
function
is
impaired
patients
with
several
neurodegenerative
diseases,
including
Alzheimer’s
Parkinson’s
disease.
As
third
most
common
disease,
although
animal
studies
have
indicated
early
dysfunction
likely
important
pathological
mechanism
underpinning
amyotrophic
lateral
sclerosis
(ALS),
no
available
study
conducted
to
thoroughly
assess
vivo
ALS
date,
particularly
early-stage
ALS.
Thus,
using
diffusion
tensor
imaging
analysis
along
perivascular
space
(ALPS)
index,
approximate
measure
of
vivo,
we
aimed
explore
whether
ALS,
diagnostic
performance
ALPS
index
distinguishing
between
healthy
subjects.
We
also
identify
relationships
clinical
disabilities
sleep
problems
In
this
retrospective
study,
King’s
Stage
1
were
defined
as
enrolled
56
32
age-
sex-matched
control
All
participants
completed
screening,
assessment
analysis.
For
assessment,
Pittsburgh
Sleep
Quality
Index,
Epworth
Sleepiness
Scale
polysomnography
used.
Compared
subjects,
had
a
significantly
lower
after
family-wise
error
correction
(P
<
0.05).
Moreover,
receiver
operating
characteristic
showed
area
under
curve
for
was
0.792
(95%
confidence
interval
0.700–0.884).
Partial
correlation
analyses
correlated
disability
disturbances
Multivariate
efficiency
(r
=
0.419,
P
0.002)
periodic
limb
movements
−0.294,
0.017)
significant
predictive
factors
conclusion,
our
continues
support
role
pathology,
provide
additional
insights
into
value
its
suggest
improvement
may
be
promising
strategy
slowing
process
Future
are
needed
therapeutic
individuals
presymptomatic-stage
diseases.
Annals of Neurology,
Journal Year:
2023,
Volume and Issue:
94(4), P. 672 - 683
Published: June 28, 2023
Emerging
pathological
evidence
suggests
that
there
is
an
association
between
glymphatic
dysfunction
and
the
progression
of
Parkinson's
disease
(PD).
However,
clinical
this
remains
lacking.In
study,
index
for
diffusion
tensor
image
analysis
along
perivascular
space
(ALPS
index)
was
calculated
to
evaluate
function.Overall,
289
patients
with
PD
were
enrolled
in
cross-sectional
study.
The
ALPS
found
be
negatively
correlated
age,
severity,
dyskinesia.
In
longitudinal
information
on
a
total
95
5-year
follow-up
examinations
collected
from
Progression
Marker
Initiative,
33
which
classified
into
low
group,
all
others
mid-high
group
based
first
tertile
baseline
index.
results
regression
indicated
significant
main
effect
autonomic
dysfunction,
as
well
activities
daily
living.
addition,
had
faster
deterioration
MDS-UPDRS
part
III
II,
Symbol
Digit
Modalities
Test
Hopkins
Verbal
Learning
Test.
Path
showed
acted
mediator
tTau/
Aβ1-42
cognitive
change
score
at
year
4
5.The
index,
neuroimaging
marker
function,
motor
symptoms,
predictive
symptoms
function.
Additionally,
function
may
mediate
role
toxic
protein
decline.
ANN
NEUROL
2023;94:672-683.
NMR in Biomedicine,
Journal Year:
2024,
Volume and Issue:
37(9)
Published: May 7, 2024
Abstract
Cerebrospinal
fluid
(CSF)
plays
a
critical
role
in
metabolic
waste
clearance
from
the
brain,
requiring
its
circulation
throughout
various
brain
pathways,
including
ventricular
system,
subarachnoid
spaces,
para‐arterial
interstitial
and
para‐venous
spaces.
The
complexity
of
CSF
has
posed
challenge
obtaining
noninvasive
measurements
dynamics.
assessment
dynamics
circulatory
pathways
is
possible
using
diffusion
magnetic
resonance
imaging
(MRI)
with
optimized
sensitivity
to
incoherent
water
movement
across
brain.
This
review
presents
an
overview
both
established
emerging
MRI
techniques
designed
measure
their
potential
clinical
applications.
discussion
offers
insights
into
optimization
acquisition
parameters
enhance
specificity
metrics
on
underlying
Lastly,
we
emphasize
importance
cautious
interpretations
diffusion‐based
imaging,
especially
when
differentiating
between
tissue‐
fluid‐related
changes
or
elucidating
structural
versus
functional
alterations.
Cells,
Journal Year:
2023,
Volume and Issue:
12(11), P. 1450 - 1450
Published: May 23, 2023
Amyotrophic
lateral
sclerosis
(ALS)
and
frontotemporal
dementia
(FTD)
are
fatal
neurodegenerative
disorders
often
co-occurring
in
the
same
patient,
a
feature
that
suggests
common
origin
of
two
diseases.
Consistently,
pathological
inclusions
proteins
as
well
mutations
genes
can
be
identified
both
ALS/FTD.
Although
many
studies
have
described
several
disrupted
pathways
within
neurons,
glial
cells
also
regarded
crucial
pathogenetic
contributors
Here,
we
focus
our
attention
on
astrocytes,
heterogenous
population
perform
functions
for
optimal
central
nervous
system
homeostasis.
Firstly,
discuss
how
post-mortem
material
from
ALS/FTD
patients
supports
astrocyte
dysfunction
around
three
pillars:
neuroinflammation,
abnormal
protein
aggregation,
atrophy/degeneration.
Furthermore,
summarize
current
attempts
at
monitoring
living
using
either
novel
imaging
strategies
or
soluble
biomarkers.
We
then
address
pathology
is
recapitulated
animal
cellular
models
used
these
to
understand
molecular
mechanisms
driving
platforms
pre-clinical
testing
therapeutics.
Finally,
present
clinical
trials
ALS/FTD,
restricting
discussion
treatments
modulate
functions,
directly
indirectly.
