Quantitative Imaging in Medicine and Surgery,
Journal Year:
2024,
Volume and Issue:
14(3), P. 2296 - 2308
Published: March 1, 2024
Background:
Obesity
is
considered
a
risk
factor
for
the
development
of
several
neurodegenerative
diseases,
including
Parkinson's
disease
(PD).
Recent
studies
have
revealed
that
glymphatic
function
compromised
in
PD
patients.
This
study
aims
to
investigate
impact
different
body
mass
index
(BMI)
statuses
on
system
patients
using
diffusion
tensor
image
analysis
along
perivascular
space
(DTI-ALPS)
method.
Journal of Neurology,
Journal Year:
2024,
Volume and Issue:
271(8), P. 5598 - 5609
Published: June 24, 2024
Abstract
Background
Although
brain
glymphatic
dysfunction
is
a
contributing
factor
to
the
cognitive
deficits
in
Parkinson’s
disease
(PD),
its
role
longitudinal
progression
of
remains
unknown.
Objective
To
investigate
function
PD
with
mild
impairment
(MCI)
that
progresses
dementia
(PDD)
and
determine
predictive
value
identifying
individuals
at
high
risk
for
developing
dementia.
Methods
We
included
64
patients
meeting
criteria
MCI
categorized
them
as
either
progressed
PDD
(converters)
(
n
=
29)
or
did
not
progress
(nonconverters)
35),
depending
on
whether
they
developed
during
follow-up.
Meanwhile,
35
age-
gender-matched
healthy
controls
(HC)
were
included.
Bilateral
diffusion-tensor
imaging
analysis
along
perivascular
space
(DTI-ALPS)
indices
enlarged
spaces
(EPVS)
volume
fraction
bilateral
centrum
semiovale,
basal
ganglia
(BG),
midbrain
compared
among
three
groups.
Correlations
DTI-ALPS
index
EPVS,
well
performance
analyzed.
Additionally,
we
investigated
mediation
effect
EPVS
function.
Results
converters
had
lower
composites
scores
executive
domains
than
nonconverters
P
<
0.001).
Besides,
significantly
left
hemisphere
0.001)
larger
BG-PVS
0.03)
HC
nonconverters.
Lower
increased
associated
worse
global
However,
there
was
no
significant
mediating
effect.
Receiver
operating
characteristic
revealed
could
effectively
identify
an
area
under
curve
(AUC)
0.850.
Conclusion
The
reduction
activity,
measured
by
DTI-ALPS,
potentially
be
used
non-invasive
indicator
forecasting
conversion
before
onset
patients.
European Journal of Neurology,
Journal Year:
2023,
Volume and Issue:
31(1)
Published: Oct. 12, 2023
We
aimed
to
evaluate
(i)
glymphatic
system
function
in
patients
with
focal
epilepsy
comparison
healthy
controls,
and
(ii)
the
association
between
anti-seizure
medication
(ASM)
response
by
using
diffusion
tensor
image
analysis
along
perivascular
space
(DTI-ALPS).
Schizophrenia Bulletin,
Journal Year:
2024,
Volume and Issue:
50(5), P. 1223 - 1231
Published: April 6, 2024
Abstract
Background
and
Hypothesis
Despite
the
well-documented
structural
functional
brain
changes
in
schizophrenia,
potential
role
of
glymphatic
dysfunction
remains
largely
unexplored.
This
study
investigates
system’s
function
utilizing
diffusion
tensor
imaging
(DTI)
to
analyze
water
along
perivascular
space
(ALPS),
examines
its
correlation
with
clinical
symptoms.
Study
Design
A
cohort
consisting
43
people
schizophrenia
108
healthy
controls
was
examined.
We
quantified
metrics
x-,
y-,
z-axis
both
projection
association
fibers
derive
DTI-ALPS
index,
a
proxy
for
activity.
The
differences
ALPS
index
between
groups
were
analyzed
using
2-way
ANCOVA
controlling
age
sex,
while
partial
correlations
assessed
variables.
Results
People
showed
significantly
reduced
across
whole
within
hemispheres
(F
=
9.001,
P
.011;
F
10.024,
5.927,
.044;
false
discovery
rate
corrected),
indicating
schizophrenia.
group
by
cognitive
performance
interaction
effects
on
not
observed.
Moreover,
lower
associated
poorer
specific
neuropsychological
tests
Conclusion
Our
highlights
correlated
more
pronounced
impairments.
suggests
that
may
contribute
pathophysiology
offering
new
insights
into
underlying
mechanisms.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 2, 2024
In
recent
years,
the
glymphatic
system
has
received
increasing
attention
due
to
its
possible
implications
in
biological
mechanisms
associated
with
neurodegeneration.
field
of
human
brain
mapping,
this
led
development
diffusion
tensor
image
analysis
along
perivascular
space
(DTI-ALPS)
index.
While
index
been
repeatedly
used
investigate
differences
between
neurodegenerative
disorders
and
healthy
controls,
a
comprehensive
evaluation
stability
across
multiple
measurements
different
is
still
missing.
study,
we
perform
Bayesian
meta-analysis
aiming
assess
consistency
DTI-ALPS
results
previously
reported
for
12
studies
on
Parkinson's
disease
11
Alzheimer's
disease.
We
also
evaluated
if
measured
value
can
quantitatively
inform
diagnostic
process,
allowing
disambiguation
these
two
disorders.
Our
results,
expressed
terms
Bayes'
Factor
values,
confirmed
that
consistent
measuring
functioning
subjects
patients
both
(Log10(BF10)
=
30)
10).
Moreover,
showed
be
compare
directly,
therefore
providing
first
proof
concept
supporting
reliability
taking
into
consideration
neuroimaging
measurement
process.
study
underscores
potential
advancing
our
understanding
pathologies
enhancing
clinical
diagnostics.
Japanese Journal of Radiology,
Journal Year:
2024,
Volume and Issue:
42(10), P. 1146 - 1156
Published: May 31, 2024
Abstract
Purpose
To
investigate
glymphatic
system
function
in
patients
with
brain
tumors,
including
both
primary
and
secondary
using
diffusion
tensor
imaging
along
perivascular
spaces
(DTI-ALPS).
Methods
We
retrospectively
analyzed
the
MR
DTI
of
24
unilateral
tumors
compared
them
age
sex-matched
controls.
DTI-ALPS
index
ipsi-
contralateral
hemispheres.
The
region
interest
was
placed
periventricular
vessels
adjacent
to
lateral
ventricles.
Differences
between
sex,
age,
kind
tumor
(primary
or
metastasis)
were
evaluated.
Correlations
tumor's
apparent
coefficient
(ADC)
also
investigated.
Results
significantly
lower
(
p
<
0.05)
tumor-affected
hemisphere
(mean
=
1.26
±
0.24)
than
1.43
0.28).
A
comparison
healthy
controls
revealed
no
significant
difference
on
matched
ipsilateral
side.
However,
side
larger
HC.
Additionally,
statistically
differences
found
when
analyzing
vs.
entity.
we
did
not
find
a
correlation
patient
ADC.
Conclusion
decreased
may
be
related
impaired
function.
cancer
is
often
systemic
disease;
thus,
from
generally
considered
as
normal
control.
Nonetheless,
does
only
reflect
but
it
can
influenced
by
factors
such
axonal
degeneration.
Therefore,
directly
waste
clearance
changes
should
interpreted
carefully.
European Journal of Neurology,
Journal Year:
2024,
Volume and Issue:
31(12)
Published: Oct. 19, 2024
Abstract
Background
and
purpose
Glymphatic
dysfunction
may
play
a
significant
role
in
the
development
of
neurodegenerative
diseases.
We
aimed
to
evaluate
association
between
glymphatic
risk
malignant
event/clinical
milestones
Parkinson
disease
(PD).
Methods
This
study
included
236
patients
from
August
2014
December
2020.
Diffusion
tensor
imaging
analysis
along
perivascular
space
(DTI‐ALPS)
index
was
calculated
as
an
approximate
measure
function.
The
primary
outcomes
were
four
clinical
including
recurrent
falls,
wheelchair
dependence,
dementia,
placement
residential
or
nursing
home
care.
associations
DTI‐ALPS
with
examined
using
multivariate
Cox
proportional
hazards
regression
models.
Then,
logistic
repeated
variables
individually
combination
two
explore
ability
distinguish
who
reached
within
5‐year
period.
Results
A
total
175
PD
baseline
follow‐up
assessments
included.
lower
independently
associated
increased
dementia.
Additionally,
103
monitored
over
5
years,
model
combining
showed
better
performance
for
predicting
dependence
years
than
alone.
Conclusions
dysfunction,
measured
by
index,
PD.
finding
implies
that
therapy
targeting
system
serve
viable
strategy
slowing
down
progression
Quantitative Imaging in Medicine and Surgery,
Journal Year:
2025,
Volume and Issue:
15(2), P. 1411 - 1424
Published: Jan. 24, 2025
Increased
iron
accumulation
measured
by
quantitative
susceptibility
mapping
(QSM)
has
been
observed
in
various
brain
regions,
especially
substantia
nigra
(SN),
Parkinson's
disease
(PD).
Glymphatic
dysfunction
evaluated
diffusion
tensor
image
analysis
along
the
perivascular
space
(DTI-ALPS)
PD
also
attracted
much
attention
recently.
This
study
aimed
to
compare
and
combine
DTI-ALPS
QSM
of
SN
diagnosis
severity
assessment
PD.
As
a
case-control
study,
we
retrospectively
recruited
60
patients
matched
healthy
controls.
The
index,
SN,
their
combination
were
calculated
further
compared
between
two
groups.
Receiver
operating
characteristic
(ROC)
curves
used
assess
diagnostic
performance.
We
analyzed
correlation
Movement
Disorder
Society-Unified
Disease
Rating
Scale
(MDS-UPDRS)
part
III
score
with
SN.
average
was
significantly
lower,
whereas
bilateral
higher
[median
(interquartile
range):
1.38
(1.26-1.53);
0.09
(0.07-0.10)]
controls
[1.52
(1.41-1.71),
P<0.001;
0.08
(0.07-0.09),
P=0.020].
showed
area
under
curve
(AUC)
0.801
than
that
(0.729)
or
(0.624)
discriminating
from
Moreover,
significant
correlations
MDS-UPDRS
(rho
=-0.276,
P=0.034).
are
potential
biomarkers
for
them
may
improve
