Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 29
Published: Nov. 7, 2023
Journal of Cancer Research and Therapeutics, Journal Year: 2025, Volume and Issue: 21(2), P. 323 - 333
Published: May 1, 2025
ABSTRACT Cancer metastasis is the leading cause of death in patients. In recent years, there has been a growing recognition role tumor-associated microflora tumor metastasis. The connection between oral and gut microenvironment also extensively studied. migration closely associated with development. Although awareness regarding significant impact microbial communities on human health, focus their relationship host organisms, particularly those related to microflora, remains inadequate. As an integral part body, crucial for regulating cancer risk preventing recurrence. oral-gut axis plays indispensable immunity, many types cancers, such as colorectal, pancreatic, breast, are significantly influenced by internal communities. However, further exploration into mechanisms underlying intratumoral necessary achieve comprehensive understanding. We have summarized analyzed articles PubMed. This article reviews immune system, explores translocation intestinal flora microenvironment, analyzes specific involved during evolution progression tumors, elaborates correlations occurrence development tumors changes microflora. Finally, summary these abovementioned points provided.
Language: Английский
Citations
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Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Aug. 6, 2024
Recent studies have shown that gut microbiota may be related to the occurrence of brain tumors, but direct evidence is lacking. This study used Mendelian randomization (MR) method explore potential causal link between and tumors.
Language: Английский
Citations
2
Cancer Reports, Journal Year: 2023, Volume and Issue: 7(2)
Published: Dec. 9, 2023
Abstract Background Glioblastoma (GB) is an aggressive and deadly brain tumor with a poor prognosis despite the current standard of care, including surgery, radiation, chemotherapy. Recent Findings In recent years, there has been increasing interest in potential immunotherapies, seen to be effective treating other cancers, treatment GB. This comprehensive review presents in‐depth analysis remarkable progress immunotherapy GB treatment, focusing on human clinical studies. It also analyzes findings, challenges, limitations that underscore transformative managing Of particular significance, it delves into intriguing interaction microbiome as novel avenue for enhancing outcomes Conclusion study sheds light complex therapy landscape cutting‐edge strategies show promise patient prognosis.
Language: Английский
Citations
4
Neuro-Oncology, Journal Year: 2024, Volume and Issue: 26(11), P. 1964 - 1980
Published: July 11, 2024
Abstract Brain tumors, particularly glioblastoma (GBM), are devastating and challenging to treat, with a low 5-year survival rate of only 6.6%. Mouse models established understand tumorigenesis develop new therapeutic strategies. Large-scale genomic studies have facilitated the identification genetic alterations driving human brain tumor development progression. Genetically engineered mouse (GEMMs) clinically relevant widely used investigate origin. Additionally, syngeneic implantation models, utilizing cell lines derived from GEMMs or other sources, popular for their consistent relatively short latency period, addressing various cancer research questions. In recent years, success immunotherapy in specific types has led surge immunology-related which specifically necessitates utilization immunocompetent models. this review, we provide comprehensive summary adult emphasizing key features such as model origin, alteration background, oncogenic mechanisms, immune-related characteristics. Our review serves valuable resource community, aiding selection appropriate study immunology.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Abstract Craniopharyngioma (CP) is an intracranial tumor with high mortality and morbidity. Though biologically benign, CP will damage the hypothalamus, inducing comorbidities such as obesity, metabolic syndrome, cognitive impairments. The roles of gut microbiome serum metabolome in CP‐associated hypothalamic are aimed to be explored. Patients characterized by increased Shannon diversity, Eubacterium , Clostridium Roseburia alongside decreased Alistipes Bacteroides . CP‐enriched taxa positively correlated dyslipidemia decline, while CP‐depleted negatively associated fatty liver. Subsequent metabolomics identified notably up‐regulated purine metabolism, integrative analysis indicated association between altered microbiota elevated hypoxanthine. Phenotypic study multi‐omics Rax‐CreER T2 ::Braf V600E/+ ::Pten Flox/+ mouse model validated potential involvement dysregulated metabolism comorbidities. To further consolidate this, intervention experiments performed it found that hypoxanthine co‐variated severity abundance induced along redox imbalance target organs (liver brain cortex). Overall, demonstrated signatures hypothalamic‐comorbidities, unveiled may mediate development progression hypothalamic‐comorbidities.
Language: Английский
Citations
1
MedComm, Journal Year: 2024, Volume and Issue: 6(1)
Published: Dec. 20, 2024
Abstract Metastatic brain tumors, also called metastasis (BM), represent a challenging complication of advanced tumors. Tumors that commonly metastasize to the include lung cancer and breast cancer. In recent years, prognosis for BM patients has improved, significant advancements have been made in both clinical preclinical research. This review focuses on originating from We briefly overview history epidemiology BM, as well current diagnostic treatment paradigms. Additionally, we summarize multiomics evidence mechanisms tumor occurrence development era artificial intelligence discuss role microenvironment. Preclinically, introduce establishment models, detailed molecular mechanisms, cutting‐edge methods. is primarily treated with comprehensive approach, including local treatments such surgery radiotherapy. For cancer, targeted therapy immunotherapy shown efficacy, while monoclonal antibodies, tyrosine kinase inhibitors, antibody–drug conjugates are effective BM. Multiomics approaches assist diagnosis treatment, revealing complex Moreover, agents often need cross blood–brain barrier achieve high intracranial concentrations, small‐molecule nanoparticles, peptide drugs. Addressing imperative.
Language: Английский
Citations
1
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 20, 2024
The role of inflammation in the aetiopathogenesis malignant brain tumours is increasingly recognised. Chronic inflammation, characterised by a sustained immune response and tissue remodelling, contributes to development progression tumours. Activated microglia infiltrating cells release proinflammatory cytokines reactive oxygen species, creating neuroinflammatory environment that promotes tumour growth. This persistent leads DNA damage, mutations epigenetic changes, thus favouring malignancy. Epidemiological studies have linked chronic inflammatory diseases infections an increased risk Underlying mechanisms include activating signalling pathways such as nuclear factor kappa B (NF-κB) signal transducer activator transcription 3 (STAT3), which promote cell proliferation survival. In contrast, mediators angiogenesis evasion system. text discusses markers bacterial viral developing
Language: Английский
Citations
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Clinical Neurology and Neurosurgery, Journal Year: 2023, Volume and Issue: 236, P. 108102 - 108102
Published: Dec. 23, 2023
Language: Английский
Citations
0
Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 29
Published: Nov. 7, 2023
Citations
0