Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Allergy, Journal Year: 2023, Volume and Issue: 79(2), P. 353 - 383

Published: Dec. 12, 2023

Abstract Nutritional Immunity is one of the most ancient innate immune responses, during which body can restrict nutrients availability to pathogens and restricts their uptake by gut mucosa (mucosal block). Though this be a beneficial strategy infection, it also associated with non‐communicable diseases—where pathogen missing; leading increased morbidity mortality as micronutritional distribution in hindered. Here, we discuss acute response respect nutrients, opposing nutritional demands regulatory inflammatory cells particularly focus on some linked inflammation such iron, vitamins A, Bs, C, other antioxidants. We propose that while absorption certain micronutrients hindered inflammation, dietary lymph path remains available. As such, several clinical trials investigated role lymphatic system protein absorption, following ketogenic diet an intake antioxidants, vitamins, minerals, reducing ameliorating disease.

Language: Английский

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Pharmacodynamic Mechanisms of Cicadae Periostracum in Parkinson’s Disease: A Metabolomics-Based Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 544 - 544

Published: Jan. 10, 2025

Cicadae Periostracum (CP) is a traditional Chinese animal-derived medicine with the potential to treat Parkinson’s disease (PD). This study aims explore pharmacodynamic mechanisms of CP against PD-based on metabolomics technology and provide theoretical basis for developing new anti-PD medicine. First, MPP+-induced SH-SY5Y cells were used evaluate activity CP. In animal study, an MPTP-induced PD mouse model was employed assess CP’s therapeutic effects. Immunofluorescence (IF) staining Western blotting (WB) its neuroprotective neurons. A Serum analysis conducted examine regulatory effects metabolites identify vital metabolic pathways. Finally, cellular experiments performed validate critical Cellular demonstrated that mitigates cytotoxicity, inhibits apoptosis, restores mitochondrial homeostasis. Animal revealed significantly alleviates dyskinesia in mice, enhances motor performance, neuronal integrity while reducing α-synuclein (α-syn) aggregation striatum (STR), showing strong effect. Metabolomic can improve disorders ten biomarkers are mainly involved amino acid metabolism fatty β-oxidation closely related oxidative stress pathway verification performed, results show exerted through dual signaling pathways Bcl-2/Bax/Caspase-3 Nrf2/HO-1. provides comprehensive strategy elucidating by which exerts PD, highlighting drugs.

Language: Английский

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Integrated genetic analysis and single cell-RNA sequencing for brain image-derived phenotypes and Parkinson's disease

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 138, P. 111317 - 111317

Published: March 11, 2025

Previous studies have reported Parkinson's disease (PD) patients usually changes in brain image-derived phenotypes (IDPs). However, the role of genetic factors their association and biological mechanism remains unclear. We aimed to unveil links between IDPs PD. Using genome-wide study (GWAS) summary statistics single-cell RNA sequencing (scRNA-seq) data, we performed a comprehensive analysis 624 The correlations causality were examined by linkage disequilibrium score regression (LDSC), two-sample bidirectional Mendelian randomization (MR) meta-analysis. Potential shared genes identified using MAGMA PLACO. Finally, pathway enrichment FUMA Metascape, scRNA-seq determine mechanisms gene expression atlas across various cell types tissue. LDSC revealed that 50 genetically correlated with PD (P < 0.05), which 5 IDPs, exhibited putative on through MR 0.05). For instance, increased volume right thalamus (IVW: OR = 2.08, 95 % CI: 1.33 3.25, PFDR 0.03) was positively risk PD, also supported replicated 1.63, 1.17-2.26, 0.02) FinnGen meta-analysis (OR 1.78, 1.36-2.31, 5.00 × 10-4). Additionally, 56 unique pleiotropic genes, such as FAM13A, notable neuronal cells. Biological these enriched tissues variety pathways negative regulation neuron apoptotic processes. indicated architecture These findings might provide insights therapeutic intervention early prediction at imaging level.

Language: Английский

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Targeting mitochondria-regulated ferroptosis: A new frontier in Parkinson’s Disease therapy

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110439 - 110439

Published: March 1, 2025

Language: Английский

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Exploring the metabolic implications of blue light exposure during daytime in rats

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116436 - 116436

Published: May 8, 2024

Excessive exposure to light is a global issue. Artificial pollution has been shown disrupt the body's natural circadian rhythm. To investigate impacts of on metabolism, we studied Sprague-Dawley rats chronically exposed red or blue during daytime nighttime. Rats in experimental group were extended for 4 hours nighttime simulate effects excessive usage. Strikingly, found systemic metabolic alterations only induced by daytime. Furthermore, conducted metabolomic analyses cerebrospinal fluid, serum, heart, liver, spleen, adrenal, cerebellum, pituitary, prostate, spermatophore, hypothalamus and kidney from control Significant changes metabolites have observed Metabolic encompassing pyruvate glutathione metabolism homocysteine degradation, phosphatidylethanolamine biosynthesis, phospholipid exhibit analogous patterns those inherent specific physiological processes, notably neurodevelopment, cellular injury, oxidative stress, autophagic pathways. Our study provides insights into tissue-specific may help explain potential mechanisms photopathogenesis.

Language: Английский

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Developmental and Neuroprotective Effects of α-Terpineol in MPTP-Induced Parkinsonism in Zebrafish Larvae

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(3)

Published: May 8, 2025

Language: Английский

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Association of accelerometer-measured physical activity intensity, sedentary time, and exercise time with incident Parkinson’s disease

npj Digital Medicine, Journal Year: 2023, Volume and Issue: 6(1)

Published: Nov. 28, 2023

Abstract Evidence regarding the association between physical activity and Parkinson’s disease (PD) risk is generally limited due to use of self-report questionnaires. We aimed quantify separate combined effects accelerometer-measured light (LPA), moderate-to-vigorous (MVPA), sedentary time exercise timing with incident PD. 96,422 participants without prior PD usable accelerometer data were included from UK Biobank. Time spent in activity, LPA, MVPA, estimated using machine learning models. The study outcome was Over a median follow-up duration 6.8 years, 313 developed There L-shaped for LPA reversed time, (all P nonlinearity < 0.001). Similar trends found across three time-windows (morning, midday-afternoon, evening). Compared those both low (<3.89 h/day) MVPA (<0.27 h/day), adjusted HR (95% CI) 0.49 (0.36–0.66), 0.19 (0.36–0.66) 0.13 (0.09–0.18), respectively, high only, MVPA. Moreover, (≥9.41 (adjusted HR, 5.59; 95% CI: 4.10–7.61), 3.93; 2.82–5.49) had highest In conclusion, regardless evening), there an inverse positive

Language: Английский

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The Effects of Ketogenic Diet on Brain Gene Expressions in Type 2 Diabetes Background

Neuroscience, Journal Year: 2024, Volume and Issue: 549, P. 101 - 109

Published: May 10, 2024

Language: Английский

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Roles of Lysine Methylation in Glucose and Lipid Metabolism: Functions, Regulatory Mechanisms, and Therapeutic Implications

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 862 - 862

Published: July 19, 2024

Glucose and lipid metabolism are essential energy sources for the body. Dysregulation in these metabolic pathways is a significant risk factor numerous acute chronic diseases, including type 2 diabetes (T2DM), Alzheimer’s disease (AD), obesity, cancer. Post-translational modifications (PTMs), which regulate protein structure, localization, function, activity, play crucial role managing cellular glucose metabolism. Among PTMs, lysine methylation stands out as key dynamic modification vital epigenetic regulation of gene transcription. Emerging evidence indicates that significantly impacts by modifying enzymes proteins. This review summarizes current understanding methylation’s regulatory mechanisms We highlight involvement methyltransferases (KMTs) demethylases (KDMs) generating abnormal signals affecting pathways. Additionally, we discuss chemical biology pharmacology KMT KDM inhibitors targeted degraders, emphasizing their clinical implications diseases such diabetes, neurodegenerative disorders, cancers. suggests targeting could be an ideal therapeutic strategy treating diseases.

Language: Английский

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Characteristics of gut flora in children who go to bed early versus late

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 6, 2024

Investigating the characteristics of gut flora in children who go to bed early versus late. The study sample consisted 88 healthy aged 2–14 years, with an equal number boys and girls. researchers collected faecal samples from all participants sequenced genome their flora. Findings indicate that beta diversity was statistically significant at genus level for both late sleeper groups (P = 0.045). Furthermore, alpha indicators, including Simpson's index 0.0011) Shannon's 0.0013), exhibited higher values level. differences observed terms species diversity, abundance, metabolic pathways offer potential avenues implementing pharmacological interventions aimed addressing sleep disorders children.

Language: Английский

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