Neuroscience, Journal Year: 2024, Volume and Issue: 560, P. 1 - 10
Published: Sept. 16, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: April 10, 2024
Background The systemic immuno-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte (PLR) are widely used have been shown to be predictive indicators of various diseases. Diabetic nephropathy (DN), retinopathy (DR), peripheral neuropathy (DPN) the most prominent common microvascular complications, which seriously negative impacts on patients, families, society. Exploring associations with these three diabetic complications main purpose. Methods There were 1058 individuals type 2 diabetes mellitus (T2DM) in this retrospective cross-sectional study. SII, NLR, PLR calculated. diseases diagnosed by endocrinologists. Logistic regression subgroup analysis applied evaluate association between NLP, complications. Results significantly associated risk DN [odds ratios (ORs): 1.52, 1.71, 1.60, respectively] DR [ORs: 1.57, 1.79, 1.55, multivariate logistic regression. When NLR ≥2.66, OR was higher for DPN (OR: 1.985, 95% confidence interval: 1.29–3.05). Subgroup showed no significant positive across different demographics comorbidities, including sex, age, hypertension, HbA1c (glycated hemoglobin), dyslipidemia. Conclusion This study found a relationship DN, DR, DPN. In contrast, SII only DR. Therefore, diagnosis highly valuable.
Language: Английский
Citations
22
Journal of Diabetes and its Complications, Journal Year: 2025, Volume and Issue: 39(2), P. 108950 - 108950
Published: Jan. 14, 2025
Language: Английский
Citations
2
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 589 - 589
Published: Feb. 28, 2025
Diabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes mellitus, characterized by progressive nerve damage driven chronic hyperglycemia and systemic inflammation. The pathophysiology DPN significantly influenced pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α. These cytokines promote oxidative stress, vascular dysfunction, neuronal degeneration activating important signaling pathways including NF-κB MAPK. While IL-6 promotes microenvironment, increasing neuropathic pain, TNF-α IL-1β worsen Schwann cell failure compromising axonal support causing demyelination. Immune infiltration TLR activation increase the inflammatory cascade in DPN, resulting persistent neuroinflammatory state that sustains injury. main characteristics are degeneration, decreased neurotrophic support, which weaken transmission susceptibility to damage. Advanced glycation end-products, TNF-α, CXCL10 examples biomarkers may be used for early diagnosis disease progression monitoring. Additionally, crucial molecular targets have been found using proteomic transcriptome techniques, enabling precision medicine treatment DPN. This review emphasizes importance cytokine pathogenesis how cytokine-targeted treatments might reduce inflammation, restore function, improve clinical outcomes diabetic patients.
Language: Английский
Citations
2
CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)
Published: Oct. 5, 2023
Diabetic peripheral neuropathy (DPN) constitutes a debilitating complication associated with diabetes. Although, the past decade has seen rapid developments in understanding complex etiology of DPN, there are no approved therapies that can halt development or target damaged nerve. Therefore, clarifying pathogenesis DPN and finding effective treatment crucial issues for clinical management DPN.
Language: Английский
Citations
26
Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 1, 2025
ABSTRACT Humans are perhaps evolutionarily engineered to get deeply addicted sugar, as it not only provides energy but also helps in storing fats, which survival during starvation. Additionally, sugars (glucose and fructose) stimulate the feel‐good factor, they trigger secretion of serotonin dopamine brain, associated with reward sensation, uplifting mood general. However, when consumed excess, contributes imbalance, weight gain, obesity, leading onset a complex metabolic disorder, generally referred diabetes. Type 2 diabetes mellitus (T2DM) is one most prevalent forms diabetes, nearly affecting all age groups. T2DM clinically diagnosed cardinal sign chronic hyperglycemia (excessive sugar blood). Chronic hyperglycemia, coupled dysfunctions pancreatic β‐cells, insulin resistance, immune inflammation, further exacerbate pathology T2DM. Uncontrolled T2DM, major public health concern, significantly toward progression several micro‐ macrovascular diseases, such diabetic retinopathy, nephropathy, neuropathy, atherosclerosis, cardiovascular including cancer. The current review discusses epidemiology, causative factors, pathophysiology, comorbidities, existing emerging therapies related It future roadmap for alternative drug discovery management
Language: Английский
Citations
1
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 8, 2024
Background Xuebifang (XBF), a potent Chinese herbal formula, has been employed in managing diabetic peripheral neuropathy (DPN). Nevertheless, the precise mechanism of its action remains enigmatic. Purpose The primary objective this investigation is to employ bioinformatics-driven approach combined with network pharmacology comprehensively explore therapeutic XBF context DPN. Study design and Methods active chemicals their respective targets were sourced from TCMSP BATMAN databases. Differentially expressed genes (DEGs) related DPN obtained GEO database. associated compiled OMIM, GeneCards, DrugBank analysis GO, KEGG pathway enrichment, as well immuno-infiltration analysis, was conducted using R language. focused on distribution within human organs or cells. Subsequently, molecular docking evaluate interactions between potential compounds concerning treatment Results study successfully identified total 122 272 XBF. 5 core for discovered by building PPI network. According GO enrichment mechanisms could be inflammation, immune regulation, pivotal signalling pathways such TNF, TLR, CLR, NOD-like receptor pathways. These findings further supported infiltration localization Moreover, simulations demonstrated strong binding affinity carefully selected targets. Conclusion In summary, proposes novel model DPN, it also offers new perspective exploring principles traditional medicine (TCM) clinical management
Language: Английский
Citations
4
Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 249, P. 108719 - 108719
Published: Jan. 7, 2025
Diabetic polyneuropathy is the common neuropathy of diabetes. However, several inflammatory neuropathies may occur during Chronic demyelinating polyradiculoneuropathy (CIDP) represents most treatable example. There has been uncertainty about a higher risk CIDP in subjects with Contradicting earlier reports, subsequent epidemiological studies failed to confirm an association. more recent from different populations have shown two-fold relative concurrent diabetes CIDP. Recognition important as treatment response rates reported comparable or without diabetes, clinical presentation and resulting disability be severe due additional axonal loss pre-existing diabetic delayed diagnosis. An association nodo-paranodopathy similarly described three-fold seropositive subjects, particularly those harbouring anti-contactin 1 antibodies. Although rare, recognition nodo-paranodopathy, characteristic features, context likewise view implications. Other are painful painless, cervical, lumbar, radiculoplexus neuropathies. These need distinguishing variant, multifocal forms CIDP, not treatable, although remit spontaneously over months years. reports possible Guillain-Barré syndrome (GBS), greater GBS severity, Finally, vasculitic also requires early suspicion, urgent investigations immunosuppressant treatment. As worldwide prevalence rises, prompt its neuropathies, essential.
Language: Английский
Citations
0
Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)
Published: Feb. 12, 2025
Diabetic neuropathy (DN) is a prevalent and painful complication of diabetes; however, the mechanisms underlying its pathogenesis remain unclear, effective clinical treatments are lacking. This study aims to explore role peroxisomes in Schwann cells DN. The abundance sciatic nerves mice or was analyzed using laser confocal super-resolution imaging western blotting. RFP-GFP-SKL (Ser-Lys-Leu) probe utilized assess pexophagy (peroxisomes autophagy) levels. To evaluate palmitoylation PEX11B, acyl-resin assisted capture (acyl-RAC) assay Acyl-Biotin Exchange (ABE) were employed. Additionally, MR (Mendelian randomization) analysis conducted investigate potential causal relationship between DN MS (Multiple sclerosis). There decrease peroxisomal diabetic mice, palmitic acid (PA) induced reduction by inhibiting biogenesis cells. Mechanistically, PA PEX11B at C25 site, disrupting self-interaction impeding peroxisome elongation. Fenofibrate, PPARα agonist, effectively rescued dysfunction caused restored mice. Lastly, indicates notable influence on MS, with onset progression intricately linked dysfunction. Targeting pathway may be an strategy for preventing treating DN, underscoring importance addressing risk
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Neuronal pain, including neuropathic migraines, and chronic pain syndromes, presents a significant global health challenge. This literature review covers studies conducted until 2024 using major databases, PubMed Google Scholar, with the search terms "Neuropathic Pain/therapy" OR "Chronic "Pain Management/methods" "Neuromodulation/methods" "Spinal Cord Stimulation" "Deep Brain "Transcranial Magnetic Direct Current "Nav1.7 Voltage-Gated Sodium Channel" "Biologics/pharmacology" "Drug Delivery Systems/methods" "Regenerative Medicine/methods" "Stem Cell Transplantation/methods" "Platelet-Rich Plasma/therapeutic use" "Tissue Engineering/methods" "Biomarkers/metabolism" "Machine Learning" "Precision Medicine." explores contemporary advancements in neurological therapy, emphasizing analytical that translate into clinical applications. The research foundation is built on modern examining mechanisms, pharmaceutical innovations, neuromodulation strategies, personalized management, regenerative medicine. Notable include neuroinflammation research, molecular genetic factor discoveries, development of selective Nav1.7 inhibitors, biologics, advanced drug delivery systems. Neuromodulation techniques, both invasive (e.g., deep brain stimulation (DBS), spinal cord (SCS)) noninvasive transcranial direct current (tDCS), magnetic (TMS)), play crucial role modulation. Regenerative approaches, stem cell platelet-rich plasma (PRP), tissue engineering, offer promising solutions for repair symptom relief. Additionally, genomic data, biomarkers, machine learning enhance precision management. Ethical considerations regarding treatment accessibility opioid alternatives remain critical, particularly Hispanic Americans facing language barriers programs like Optum. Selective serotonin reuptake inhibitors (SSRIs) continue to be widely used mental treatment. In conclusion, convergence translational innovative therapies, medicine marks transformative era improving patient outcomes quality life.
Language: Английский
Citations
0
Journal of Diabetes and its Complications, Journal Year: 2025, Volume and Issue: unknown, P. 109020 - 109020
Published: March 1, 2025
Language: Английский
Citations
0