Exploring the potential relationship between short sleep risks and cognitive function from the perspective of inflammatory biomarkers and cellular pathways: Insights from population‐based and mice studies

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Aims The molecular mechanism of short‐sleep conditions on cognition remains largely unknown. This research aimed to investigate associations between short sleep, inflammatory biomarkers and cognitive function in the US population (NHANES data 2011–2014) explore cellular mechanisms mice. Methods Systemic immune‐inflammation index (SII) was calculated using blood‐cell based biomarkers. Further, we employed integrated bioinformatics single‐cell transcriptomics (GSE137665) examine how sleep exposure influenced pathways associated with inflammation brain. To signaling biological processes deprivation, carried out enrichment analyses utilizing GO KEGG databases. Results Population results showed that, compared normal group, severe lower ability all four tests. Moreover, a higher SII level correlated scores In mice study, elevated activation pathway observed cell subgroups neurons within deprivation recovery cohorts. Additionally, heightened expression oxidative stress response noted GABAergic during deprivation. Conclusion study contributed understanding influence its mechanisms.

Language: Английский

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Saturation effects of the relationship between physical exercise and systemic immune inflammation index in the short-sleep population: a cross-sectional study

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 17, 2024

Abstract Background Short sleep can lead to an increase in inflammation and regular exercise has been shown have a mitigation effect. However, the association between physical (PE) short population is unknown intriguing issue. Methods NHANES dataset spanning years 2007 2018 were analyzed. To investigate relationship mentioned above, we carried out multivariate linear regression models controlling for sociodemographic lifestyles factors. The systemic immune index (SII) served as reflection of inflammatory potential, calculated product platelet count, neutrophil divided by lymphocyte count. Self-reported questionnaires used collect information. Results A total 14,664 participants included final analysis. Across three models, PE showed significant negative associations with SII continuous variable [Crude Model, β (95% CI): -1.261(-1.600, -0.922), p < 0.001; Model 1, -1.005(-1.344, -0.666), 2, -0.470(-0.827, -0.112), = 0.011]. consistent nature findings persisted when investigating categorized variable. By two-piecewise model, saturation effect inflection point 2400 MET-minutes/week. Conclusion This study suggested that performing no more than MET-minutes/week was associated lower levels population, while might not bring additional benefits.

Language: Английский

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Health-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 28, 2025

Language: Английский

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Impact of combiner aerobic and resistance training on depression: a systematic review and meta-analysis of randomized controlled trials

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 23, 2025

To summarize the existing literature and evaluate efficacy of combined resistance aerobic training in alleviating depressive symptoms among individuals with depression. Subgroup analyses were conducted based on study region, age, depression severity, intervention duration, frequency, whether was supervised or unsupervised. Five databases thoroughly examined from database establishment until August 20, 2024, to find randomized controlled trials that investigated impact Finally, 27 eligible studies included, involving a total 2,342 patients The outcomes indicated notably improved signs these (SMD=-1.39, 95%CI=-1.80 -0.96, p = 0.000). analysis area, severity symptoms, exercise prescription revealed had particularly significant effect middle-aged elderly depression, as well those moderate Additionally, period (9–24 weeks), frequency (3–4 times per week), weekly duration more than 180 min displayed best results. Resistance serves an efficient approach relieve depression-related Moderate intensity, offer greatest benefit.

Language: Английский

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Exploration of physical activity, sedentary behavior and insulin level among short sleepers

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 14, 2024

Sufficient physical activity and sleep duration are essential for overall health. While one-third of the US population reports short (<7 h), which is proven to link with negative health status. Current evidence on relationship between activity, sedentary behavior, serum insulin level in groups limited.

Language: Английский

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Correlation between hepatic steatosis severity diagnosed by ultrasound and metabolic indexes in elderly patients with MAFLD

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

To explore the connection between metabolic parameters and severity of hepatic steatosis determined through ultrasound in elderly individuals with dysfunction-associated fatty liver disease (MAFLD). 4,663 senior who were 65 years age or older included this research. They examined physically at Ninghai Street Community Health Service Center Yantai City June 7, 2021, October 15, 2021. There two categories identified: MAFLD group (n = 2,985) non-MAFLD 1,678). Based on ultrasonography results, further separated into three groups: mild 2,104), moderate 766), severe 115). identify indicators risk for steatosis, data was contrasted groups employing logistic regression. In comparison to group, showed significantly elevated levels body mass index (BMI), blood pressure, gender, age, lipid profile, alanine transaminase (ALT), fasting glucose (FBG; p < 0.05). Among MAFLD, there a positive correlation BMI, FBG, ALT, aspartate (AST) (p Logistic regression analysis indicated that female triglycerides (TG), serum uric acid (SUA) constituted factors increased MAFLD. The patients is correlated TG, SUA.

Language: Английский

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Relationship Between Sleep Time and Depressive Symptoms in Middle-Aged and Elderly Chinese: Mediating Role of Body Pain

Psychology Research and Behavior Management, Journal Year: 2025, Volume and Issue: Volume 18, P. 67 - 79

Published: Jan. 1, 2025

Objective: Existing research has yet to adequately examine the correlation between sleep time, body pain, and depressive symptoms. This study seeks elucidate interconnections these three elements. Methods: The used 2020 CHARLS data for analysis. To assess intricate association among symptoms, employed Spearman analysis, multiple logistic regression, restricted cubic splines, mediation effect analysis based on bootstrap testing. Results: Risk factors symptoms in middle-aged elderly Chinese include physical pain reduced duration. Results from RCS suggest that lowest risk of occurs when time population is approximately 7.5 hours. Body accounts a 19.05% mediating even after controlling confounding factors, there remains 7.5% effect. Conclusion: findings indicate significant Insufficient can lead plays partial role Keywords: people,

Language: Английский

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Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 23, 2025

Importance Oxidative stress contributes to the progression of non-alcoholic fatty liver disease (NAFLD). Antioxidants from food can reduce NAFLD incidence, and Composite Dietary Antioxidant Index (CDAI) measures total antioxidant capacity (TAC). However, relationship between CDAI in US adult population remains unclear. Objective To assess whether is associated with adults. Design, setting, participants This population-based cross-sectional study used data on adults National Health Nutrition Examination Survey (NHANES) 2005–2016 cycles. Data were analyzed January February 2024. Exposures obtained dietary intake questionnaire. Main outcomes The main outcome was which defined by score (USFLI) ≥30. Sampling weights calculated according NHANES guidelines. Results Among 9,746 included this [mean age, 48.3 years; 4,662 (47.6%) males], 3,324 (33.0%) classified as having using USFLI. In fully adjusted multivariable logistic regression, negatively (odds ratio [OR], 0.95; 95% CI, 0.93–0.98). Furthermore, individuals highest quartile 34% less likely have compared those lowest (OR, 0.66; 0.52–0.85). subgroup analyses, inversely among a BMI &lt;25 0.89; 0.83–0.95) without metabolic syndrome 0.93; 0.91–0.96). interaction tests revealed significant differences these subgroups ( P for = 0.04 0.003 syndrome). Sensitivity analyses confirmed association hepatic steatosis index (HSI) define NAFLD, applying unweighted adjusting physical activity or after excluding non-Hispanic Black participants, medications known their potential hepatotoxic effects. Conclusions relevance based six cycles (2005–2016) NHANES, population. highlights interventions incidence underscores need future research, including clinical trials mechanistic studies, further explore role antioxidants prevention management.

Language: Английский

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Age-related eye diseases and subsequent risk of mental disorders in older adults: A real-world multicenter study

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Association between metabolic score for visceral fat index and BMI-adjusted skeletal muscle mass index in American adults

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 28, 2025

The metabolic score for visceral fat (METS-VF) is a recently identified index evaluating fat, also referred to as abdominal obesity. skeletal muscle mass (SMI) serves critical measure assessing and sarcopenia. Both obesity the reduction of can significantly affect human health. However, research exploring relationship between METS-VF SMI remains limited. This study aims investigate whether association exists these two indices, if so, elucidate nature their interactions. We conducted cross-sectional using data from NHANES database, focusing on U.S. adults aged 20 years older 2013 2018. Controlling relevant covariables, we primarily investigated values utilizing weighted multivariable linear regression models. Additionally, assessed diagnostic efficacy A total 3,594 participants were included in this analysis. final adjusted model indicated that was negatively associated with SMI, coefficient β = -0.13 (95% CI: -0.14, -0.12; P < 0.001). Subgroup analyses further demonstrated negative consistent across different populations. Notably, varied diabetic nondiabetic population, well among populations classified by BMI categories. threshold effect analysis significant inflection knot at 6.33. characteristic curves subjects' work illustrated that, compared other indicators, exhibited excellent sarcopenia, an area under curve (AUC) 0.825. Our results indicate correlated United States, suggesting exerts detrimental mass. Furthermore, shows potential valuable indicator These findings underscore importance considering lipid metabolism disorders context health highlight developing prevention strategies

Language: Английский

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