Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 6, 2024
The
jawbone,
a
unique
structure
in
the
human
body,
undergoes
faster
remodeling
than
other
bones
due
to
presence
of
stem
cells
and
its
distinct
immune
microenvironment.
Long-term
exposure
jawbones
an
oral
environment
rich
microbes
results
complex
balance,
as
shown
by
higher
proportion
activated
macrophage
jaw.
Stem
derived
from
jawbone
have
propensity
differentiate
into
osteoblasts
those
bones.
microenvironment
jaw
also
promotes
osteogenic
differentiation
cells.
Here,
we
summarize
various
types
involved
reconstruction.
We
describe
mechanism
relationship
between
cells,
including
through
production
inflammatory
bodies,
secretion
cytokines,
activation
signaling
pathways,
etc.
In
addition,
comb
out
cellular
interaction
within
under
development,
homeostasis
maintenance
pathological
conditions.
This
review
aims
eclucidate
uniqueness
context
cell
microenvironment,
hopefully
advancing
clinical
regeneration
jawbone.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Feb. 8, 2024
Piezo1
(2010)
was
identified
as
a
mechanically
activated
cation
channel
capable
of
sensing
various
physical
forces,
such
tension,
osmotic
pressure,
and
shear
force.
mediates
mechanosensory
transduction
in
different
organs
tissues,
including
its
role
maintaining
bone
homeostasis.
This
review
aimed
to
summarize
the
function
possible
mechanism
mechanical
receptor
cells
tissue.
We
found
that
it
is
potential
therapeutic
target
for
treatment
diseases.
Engineered Regeneration,
Journal Year:
2024,
Volume and Issue:
5(2), P. 170 - 185
Published: March 4, 2024
Almost
every
life
form,
from
the
tiniest
bacterium
to
humans,
is
mechanosensitive,
implying
it
can
use
mechanical
stresses
trigger
certain
physiological
responses
in
form
of
electric
signals.
Mechanotransduction
largely
relies
on
ion
channels
that
respond
forces,
such
as
epithelial
sodium
channels/degenerins,
transient
receptor
potential
channel,
and
two-pore
domain
potassium
channel.
Piezo1
Piezo2
proteins
were
discovered
be
biggest
non-selective
mechanosensitive
cation
cell
membrane.
A
substantial
amount
research
has
previously
been
published
Piezo
channel's
function
touch
sensation,
balance,
cardiovascular
regression.
However,
mechanistic
perspective
must
refined
fully
understand
role
tissue
engineering.
This
review
centers
latest
insights
into
structure
channels,
activation
mechanisms,
its
interactions
with
cytoskeletal
components,
by
emphasizing
activities
different
tissues.
The
study
also
places
focus
possibilities
targeting
this
channel
family
a
regeneration
aid.
Oral Diseases,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 2, 2024
Abstract
Objective
This
study
aimed
to
assess
the
effects
of
Porphyromonas
gingivalis
outer
membrane
vesicles
(
Pg
‐OMVs)
in
chronic
periodontitis
and
explore
underlying
mechanism
involved.
Methods
In
vitro,
Pg‐OMVs
were
incubated
with
Ea.hy926
(vessel
endothelial
cells,
ECs)
evaluate
their
on
functions
investigate
mechanism.
The
dysfunction
MG63
osteoblast‐like
cells
verified
using
an
indirect
co‐culture
method.
For
vivo
studies,
micro‐CT
was
conducted
identify
alveolar
bone
mass.
Immunofluorescence
staining
confirm
levels
stimulator
interferon
genes
(STING)
blood
vessel
number
Runx2
+
around
bone.
Results
‐OMVs
endocytosed
by
ECs,
leading
dysfunction.
cGAS‐STING‐TBK1
pathway
activated
which
subsequently
inhibited
migration
early
osteogenesis
differentiation.
vivo,
promoted
resorption,
increased
STING
vessel,
decreased
Conclusions
caused
signal
cascade
thereby
impairing
ECs‐mediated
osteogenesis.
Furthermore,
aggregated
loss
altered
vessel‐mediated
elevated
STING.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 6, 2024
The
jawbone,
a
unique
structure
in
the
human
body,
undergoes
faster
remodeling
than
other
bones
due
to
presence
of
stem
cells
and
its
distinct
immune
microenvironment.
Long-term
exposure
jawbones
an
oral
environment
rich
microbes
results
complex
balance,
as
shown
by
higher
proportion
activated
macrophage
jaw.
Stem
derived
from
jawbone
have
propensity
differentiate
into
osteoblasts
those
bones.
microenvironment
jaw
also
promotes
osteogenic
differentiation
cells.
Here,
we
summarize
various
types
involved
reconstruction.
We
describe
mechanism
relationship
between
cells,
including
through
production
inflammatory
bodies,
secretion
cytokines,
activation
signaling
pathways,
etc.
In
addition,
comb
out
cellular
interaction
within
under
development,
homeostasis
maintenance
pathological
conditions.
This
review
aims
eclucidate
uniqueness
context
cell
microenvironment,
hopefully
advancing
clinical
regeneration
jawbone.
