Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability

Advanced Science, Journal Year: 2024, Volume and Issue: 11(26)

Published: May 2, 2024

Abstract Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis treatment atherosclerosis (AS) are crucial for reducing occurrence acute events. However, AS is challenging, oral anti‐AS drugs suffer from limitations like imprecise targeting low bioavailability. To overcome aforementioned shortcomings, Cur/MOF@DS developed, a nanoplatform integrating by loading curcumin (Cur) into metal−organic frameworks with nanozymes magnetic resonance imaging (MRI) properties. In addition, surface‐modification dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within plaque region. This employs mechanisms that scavenge excessive reactive oxygen species microenvironment, promote macrophage autophagy regulate polarization to realize lipid regulation. vivo vitro experiments confirm this outstanding MRI performance effects, which may provide new option AS.

Language: Английский

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Comprehensive view of macrophage autophagy and its application in cardiovascular diseases

Cell Proliferation, Journal Year: 2023, Volume and Issue: 57(1)

Published: July 11, 2023

Abstract Cardiovascular diseases (CVDs) are the primary drivers of growing public health epidemic and leading cause premature mortality economic burden worldwide. With decades research, CVDs have been proven to be associated with dysregulation inflammatory response, macrophages playing imperative roles in influencing prognosis CVDs. Autophagy is a conserved pathway that maintains cellular functions. Emerging evidence has revealed an intrinsic connection between autophagy macrophage This review focuses on role underlying mechanisms autophagy‐mediated regulation plasticity polarization, inflammasome activation, cytokine secretion, metabolism, phagocytosis, number macrophages. In addition, shown connect heart cells. It attributed specific substrate degradation or signalling activation by autophagy‐related proteins. Referring latest reports, applications targeting discussed CVDs, such as atherosclerosis, myocardial infarction, failure, myocarditis. describes novel approach for future CVD therapies.

Language: Английский

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Biomimetic-Structured Cobalt Nanocatalyst Suppresses Aortic Dissection Progression by Catalytic Antioxidation

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(25), P. 17201 - 17210

Published: June 14, 2024

As one of the most lethal cardiovascular diseases, aortic dissection (AD) is initiated by overexpression reactive oxygen species (ROS) in aorta that damages vascular structure and finally leads to massive hemorrhage sudden death. Current drugs used clinics for AD treatment fail efficiently scavenge ROS a large extent, presenting undesirable therapeutic effect. In this work, nanocatalytic antioxidation concept has been proposed elevate efficacy constructing cobalt nanocatalyst with biomimetic can pathological an efficient sustainable manner. Theoretical calculations demonstrate reaction catalyzed redox transition between hydroxocobalt(III) oxo-hydroxocobalt(V) accompanied inner-sphere proton-coupled two-electron transfer, forming nonassociated activation catalytic cycle. The action region effectively alleviates oxidative stress, which further modulates inflammatory microenvironment promoting phenotype macrophages. Consequently, smooth muscle cells are also protected from inflammation meantime, suppressing progression. This study provides approach other diseases.

Language: Английский

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Advances in the study of S100A9 in cardiovascular diseases

Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(8)

Published: March 19, 2024

Abstract Cardiovascular disease (CVD) is a group of diseases that primarily affect the heart or blood vessels, with high disability and mortality rates, posing serious threat to human health. The causative factors, pathogenesis, characteristics common CVD differ, but they all involve pathological processes such as inflammation, oxidative stress, fibrosis. S100A9 belongs S100 family calcium‐binding proteins, which are mainly secreted by myeloid cells bind Toll‐like receptor 4 for advanced glycation end products involved in regulating inflammatory response, fibrosis, vascular calcification, endothelial barrier function CVD. latest research has found key biomarker diagnosing predicting various Therefore, this article reviews progress on diagnostic predictive, therapeutic value inflammatory‐related atherosclerosis, myocardial infarction, arterial aneurysm summarizes its molecular mechanisms progression CVD, aiming explore new predictive methods identify potential intervention targets clinical practice.

Language: Английский

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WTAP Promotes Atherosclerosis by Inducing Macrophage Pyroptosis and M1 Polarization through Upregulating NLRP3

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 13, 2025

Autophagy is responsible for maintaining cellular balance and ensuring survival. plays a crucial role in the development of diseases, particularly human cancers, with actions that can either promote survival or induce cell death. However, brain tumors contribute to high levels both mortality morbidity globally, resistance treatments being acquired due genetic mutations dysregulation molecular mechanisms, among other factors. Hence, having knowledge processes advancement enlightening, current review specifically examines autophagy. The discussion would focus on pathways control autophagy tumors, its dual as tumor suppressor supporter different types like glioblastoma, glioma, ependymoma, demonstrating potential treatment. mechanisms influence metastasis drug there complex interplay between responses stress hypoxia starvation. inhibit growth by promoting apoptosis. focusing could offer fresh perspectives creating successful treatments.

Language: Английский

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Functional Role of Chrysin in Macrophage Lc3b Autophagy Through Suppression of Mir-204-5p in Diabetic Atherosclerosis

Published: Jan. 1, 2025

Language: Английский

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Internet of Things in Healthcare Research: Trends, Innovations, Security Considerations, Challenges and Future Strategy

International Journal of Intelligent Systems, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

The Internet of Things (IoT) has become a transformative force across various sectors, including healthcare, offering new opportunities for automation and enhanced service delivery. evolving architecture the IoT presents significant challenges in establishing comprehensive cyber‐physical framework. This paper reviews recent advancements IoT‐driven healthcare automation, focussing on integrating technologies such as cloud computing, augmented reality wearable devices. work examines network architectures platforms that support applications while addressing critical security privacy issues, specific threat models, attack classifications prerequisites relevant to sector. study highlights how emerging like distributed intelligence, big data analytics devices are incorporated into improve patient care streamline medical operations. findings reveal potential transform practices, particularly in‐patient monitoring, clinical decision‐making. However, concerns continue be substantial barrier. also explores implications global ehealth strategies their influence sustainable economic community growth. It proposes an innovative cooperative model mitigate risks IoT‐enabled systems. Finally, it identifies key unresolved future research IoT‐based healthcare.

Language: Английский

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Cellular stress and macrophage activation

Seminars in Immunology, Journal Year: 2025, Volume and Issue: 78, P. 101953 - 101953

Published: April 12, 2025

Language: Английский

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Novel diagnostic biomarkers regulating macrophages autophagy in ischemic cardiomyopathy: An analysis integrating bulk RNA sequencing with single-cell RNA sequencing

Immunobiology, Journal Year: 2025, Volume and Issue: 230(3), P. 152907 - 152907

Published: April 25, 2025

Macrophage autophagy plays a pivotal role in ischemia cardiomyopathy (ICM). However, the underlying mechanisms and macrophage autophagy-related biomarkers ICM have not been elucidated. Therefore, this study was designed to explore novel for ICM. The genes were downloaded from Human Autophagy Modulator intersected with differentially expressed (DEGs) of GSE46224 identified "limma" package R obtain DEGs. Immune infiltration analysis showed that macrophages dominant immune cells tissue. Then DEGs using weighted gene co-expression network (WGCNA). A total six hub obtained PPI network. All specific diagnostic significance AUCs higher than 0.7, as also validated external dataset GSE116250. RT-qPCR conducted detect mRNA expression levels vivo rat model. Single-cell RNA sequencing performed investigate profiles. Our explored their relative pathways ICM, provided gave new insight into progression mechanism

Language: Английский

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