Normothermic regional perfusion and liver transplant: expanding the donation after circulatory death donor pool DOI
Christopher C. Stahl, David Aufhauser

Current Opinion in Organ Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Purpose of review Normothermic regional perfusion (NRP) is a novel technique developed to improve organ utilization and recipient outcomes following donation after circulatory death (DCD). NRP has revolutionized DCD liver transplant by extending donor criteria reducing the incidence ischemic cholangiopathy (IC) other complications in recipients. However, there significant geographic center-specific variation use practices. This collates practices from pioneering centers across globe regarding selection criteria, techniques, viability monitoring, key areas help guide continued growth transplantation. Recent findings livers recovered using have consistently demonstrated excellent outcomes, with IC patient graft survival rates approaching those seen grafts brain donors. Recently, been working increase pool relaxing limits on quality, reconsidering markers, combining ex situ machine technologies. Summary powerful recovery technology transforming practice Current evidence suggests that could be further expanded recovery, clinical reported less stringent criteria.

Language: Английский

Normothermic Regional Perfusion Performed by a US Organ Procurement Organization for Non-thoracic Organ Donors DOI Creative Commons
Marty T. Sellers,

Jill Grandas,

Matthew Warhoover

et al.

American Journal of Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

1
Thoracoabdominal Normothermic Regional Perfusion: Real-world Experience and Outcomes of DCD Liver Transplantation DOI Creative Commons
Yanik J. Bababekov, Anna H. Ha, Trevor L. Nydam

et al.

Transplantation Direct, Journal Year: 2025, Volume and Issue: 11(3), P. e1767 - e1767

Published: Feb. 28, 2025

Background. Donation after circulatory death liver transplantation (DCD LT) is underused given historical outcomes fraught with ischemic cholangiopathy (IC). We aimed to assess 6-mo IC in LT from DCD via normothermic regional perfusion (NRP) compared static cold storage (SCS). Methods. A retrospective review of adult Maastricht-III donors and recipients at the University Colorado Hospital January 1, 2017, August 27, 2024, was performed. The rate between NRP SCS. Secondary included biochemical assessments accepted versus declined allografts allograft patient survival for SCS groups. Results. One hundred sixty-two LTs (SCS = 79; 97) were performed 150 74; 86) reached follow-up. Six-month lower (1.2% 9.5%, P 0.03). Donor Risk Index (2.44 [2.02–2.82] 2.17 [1.97–2.30], 0.002) UK Score (4.2 ± 2.9 3.2 2.3, 0.008) higher Liver Graft assessment Following Transplantation score less (–3.3 –3.1, < 0.05). There several differences median parameters during livers, including terminal biliary bicarbonate (22.7 [20.9–29.1] 10.8 [7.6–13.1] mEq/L, 0.004). no significant 12-mo or Conclusions. a disruptive innovation that improves utilization livers. Despite higher-risk donor-recipient pairing SCS, we demonstrate decrease NRP. These data facilitate benchmarking thoracoabdominal support further protocol development.

Language: Английский

Citations

0
Normothermic regional perfusion and liver transplant: expanding the donation after circulatory death donor pool DOI
Christopher C. Stahl, David Aufhauser

Current Opinion in Organ Transplantation, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Purpose of review Normothermic regional perfusion (NRP) is a novel technique developed to improve organ utilization and recipient outcomes following donation after circulatory death (DCD). NRP has revolutionized DCD liver transplant by extending donor criteria reducing the incidence ischemic cholangiopathy (IC) other complications in recipients. However, there significant geographic center-specific variation use practices. This collates practices from pioneering centers across globe regarding selection criteria, techniques, viability monitoring, key areas help guide continued growth transplantation. Recent findings livers recovered using have consistently demonstrated excellent outcomes, with IC patient graft survival rates approaching those seen grafts brain donors. Recently, been working increase pool relaxing limits on quality, reconsidering markers, combining ex situ machine technologies. Summary powerful recovery technology transforming practice Current evidence suggests that could be further expanded recovery, clinical reported less stringent criteria.

Language: Английский

Citations

0