Insights into the functional properties of thioredoxin domain-containing protein 12 (TXNDC12): antioxidant activity, immunological expression, and wound-healing effect in yellowtail clownfish (Amphiprion clarkii) DOI

M A H Dilshan,

W.K.M. Omeka,

H.M.V. Udayantha

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 154, P. 109939 - 109939

Published: Oct. 2, 2024

Language: Английский

Ferroptotic therapy in cancer: benefits, side effects, and risks DOI Creative Commons
Jiandong Diao,

Yuanyuan Jia,

Enyong Dai

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 3, 2024

Abstract Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture intracellular content release. Originally investigated as targeted therapy for cancer cells carrying oncogenic RAS mutations, ferroptosis induction now exhibits potential complement chemotherapy, immunotherapy, radiotherapy in various types. However, it can lead side effects, including immune death, bone marrow impairment, liver kidney damage, cachexia (severe weight loss muscle wasting), secondary tumorigenesis. In this review, we discuss the advantages offer an overview diverse range documented effects. Furthermore, examine underlying mechanisms explore strategies effect mitigation.

Language: Английский

Citations

31
Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis DOI

Elias S J Arnér,

Edward E. Schmidt

Advances in cancer research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 44

Published: Jan. 1, 2024

Language: Английский

Citations

8
TXNDC12 inhibits lipid peroxidation and ferroptosis DOI Creative Commons

Lanlan Tang,

Yan Yu,

Wenjun Deng

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(12), P. 108393 - 108393

Published: Nov. 4, 2023

Ferroptosis is a type of regulated cell death characterized by lipid peroxidation and subsequent damage to the plasma membrane. Here, we report ferroptosis resistance mechanism involving upregulation TXNDC12, thioredoxin domain-containing protein located in endoplasmic reticulum. The inducible expression TXNDC12 during leukemia cells inhibited knockdown transcription factor ATF4, rather than NFE2L2. Mechanistically, acts inhibit without affecting iron accumulation ferroptosis. When overexpressed, it restores sensitivity ATF4-knockdown Moreover, plays GPX4-independent role inhibiting peroxidation. absence enhances tumor-suppressive effects induction both culture animal models. Collectively, these findings demonstrate an reticulum-based anti-ferroptosis pathway cancer with potential translational applications.

Language: Английский

Citations

15
Ferroptosis in glioma therapy: advancements in sensitizing strategies and the complex tumor-promoting roles DOI

Soo Yeon Kim,

Miaolu Tang,

Tong Lu

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1840, P. 149045 - 149045

Published: May 29, 2024

Language: Английский

Citations

4
TXNDC12 knockdown promotes ferroptosis by modulating SLC7A11 expression in glioma DOI Creative Commons
Hao Yu, Kai Zhu, Minjie Wang

et al.

Clinical and Translational Science, Journal Year: 2023, Volume and Issue: 16(10), P. 1957 - 1971

Published: July 28, 2023

Ferroptosis is an iron-dependent cell death process mainly triggered by reactive oxygen species (ROS) and lipid peroxidation. Thioredoxin domain protein 12 (TXNDC12) promotes the development of some tumors; however, its function in tumor ferroptosis remains unclear. In this study, we found that knockdown TXNDC12 promoted erastin-induced increase ROS, peroxidation, Fe2+ levels, decreased glutathione content. involved regulating SLC7A11. Further studies showed decrease glioma viability. Overall, played a significant role modulating SLC7A11 expression. Thus, may provide new targets for treatment gliomas.

Language: Английский

Citations

10
Epithelial-mesenchymal Transition Promotes Metabolic Reprogramming to Suppress Ferroptosis DOI
Wenzheng Guo, Zhibing Duan, Jingjing Wu

et al.

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Ferroptosis-mediated immune responses in osteoporosis DOI Creative Commons
Xiao Wang,

Wang Yike,

Liu Gongwen

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 52, P. 116 - 125

Published: April 12, 2025

Language: Английский

Citations

0
Targeting ferroptosis opens new avenues in gliomas DOI Creative Commons

Yuxin Wei,

Yang Xu,

Qian Sun

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(12), P. 4674 - 4690

Published: Jan. 1, 2024

Gliomas are one of the most challenging tumors to treat due their malignant phenotype, brain parenchymal infiltration, intratumoral heterogeneity, and immunosuppressive microenvironment, resulting in a high recurrence rate dismal five-year survival rate. The current standard therapies, including maximum tumor resection, chemotherapy with temozolomide, radiotherapy, have exhibited limited efficacy, which is caused partially by resistance cell death. Recent studies revealed that ferroptosis, newly defined programmed death (PCD), plays crucial role occurrence progression gliomas significantly affects efficacy various treatments, representing promising therapeutic strategy. In this review, we provide comprehensive overview latest progress its involvement regulation pathophysiological process gliomas, treatment hotspots, existing obstacles, future directions worth investigating. Our review sheds light on providing novel insights into manipulating ferroptosis potential targets strategies glioma treatment.

Language: Английский

Citations

3
Modulation of Protein Disulfide Isomerase Functions by Localization: The Example of the Anterior Gradient Family DOI
Arvin Shedrach Pierre,

Noa Gavriel,

Marianne Guilbard

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 41(10-12), P. 675 - 692

Published: Feb. 27, 2024

Oxidative folding within the endoplasmic reticulum (ER) introduces disulfide bonds into nascent polypeptides, ensuring proteins' stability and proper functioning. Consequently, this process is critical for maintaining proteome integrity overall health. The productive of thousands secretory proteins requires stringent quality control measures, such as unfolded protein response (UPR) ER-Associated Degradation (ERAD), which contribute significantly to ER homeostasis. ER-localized isomerases (PDIs) play an essential role in each these processes, thereby contributing various aspects homeostasis, including redox balance, folding, signaling from nucleus.

Language: Английский

Citations

1
Insights into the functional properties of thioredoxin domain-containing protein 12 (TXNDC12): antioxidant activity, immunological expression, and wound-healing effect in yellowtail clownfish (Amphiprion clarkii) DOI

M A H Dilshan,

W.K.M. Omeka,

H.M.V. Udayantha

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 154, P. 109939 - 109939

Published: Oct. 2, 2024

Language: Английский

Citations

0