Development and evaluation of an autism pig model DOI Creative Commons
Xiao‐bing Yuan, Shuai Qiu,

Jingyan Jia

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Abstract Developing cost-effective and disease-relevant animal models is essential for advancing biomedical research into human disorders. This study investigates the feasibility of a pig model autism spectrum disorder (ASD) using embryonic exposure to valproic acid (VPA), an antiepileptic drug known increase ASD risk. We established experimental paradigms assess behavioral characteristics these models. Administration VPA Bama miniature pigs (Sus scrofa domestica) during critical stages resulted in abnormal gait, increased anxiety levels, reduced learning capabilities, altered social patterns, while largely preserving preference treated piglets. Notably, we detected significant neuroanatomical changes cortical regions associated with VPA-treated pigs, including malformation, neuronal soma size, decreased dendritic complexity, spine density maturation. Transcriptome analysis prefrontal cortex further revealed substantial alterations expression genes linked ASD, especially dopamine signaling pathway, highlighting model’s relevance potential shedding light on ASD’s underlying neuropathological molecular mechanisms. These findings suggest that could serve as promising alternative traditional rodent provide ethical substitute primates translational neurodevelopmental

Language: Английский

The Gestalt of functioning in autism revisited: First revision of the International Classification of Functioning, Disability and Health Core Sets DOI Creative Commons
Sven Bölte, Lovisa Alehagen, Melissa H. Black

et al.

Autism, Journal Year: 2024, Volume and Issue: 28(9), P. 2394 - 2411

Published: Feb. 13, 2024

Functioning is a construct capturing how an individual’s engagement in everyday life emerges from the interaction between individual and their environment. The World Health Organization’s International Classification of Functioning, Disability (ICF) provides biopsychosocial framework functioning. Previously, ICF was adapted for use autism by developing Core Sets, selection codes entire classification specific conditions. Here, we present first revision sets Delphi-like technique, based on evidence Sets validation/linking studies, stakeholder feedback, development piloting platform. Two second-level were removed, 12 added to comprehensive Set. reflect body functions various sensory domains, fine hand use, environmental factors. Changes extensive age-appropriate brief where initial or removed. revisions conducted indicate continued need regularly updating empirical involvement. We recommend updated future research practice different age groups contexts. Lay abstract Autistic people experience strengths challenges as well barriers facilitators All these factors contribute autistic can cope life, fulfill roles they choose, meet needs. Organization has developed system aiming capture many within (like someone thinks feels) outside (things around person) that influence daily living, called Health. be used purposes assess people’s situations plan support measures. Previously 2019, so-called which are shorter versions autism, research, results, community feedback. Some influencing other deemed less relevant also made designed (0–5, 6–16, ⩾17 years). Particularly, contents processing smell, touch, seeing, hearing) added. practice. These changes after 4 years there should ongoing updates involvement stakeholders.

Language: Английский

Citations

10

Preliminary Results of Sensorimotor Room Training for the Improvement of Sensory and Motor Skills in Children with Autism Spectrum Disorders DOI Creative Commons
Giulia Savarese,

Rosa Mandia,

Aldo Diavoletto

et al.

Pediatric Reports, Journal Year: 2025, Volume and Issue: 17(1), P. 4 - 4

Published: Jan. 8, 2025

Background: Motor skills in early and middle childhood are essential for physical play, social interactions, academic development. Children with autism spectrum disorder (ASD) often exhibit atypical sensory responses, which can impact self-care other developmental areas. This study explores the of motor rehabilitation using a Sensory Room to stimulate development children ASD. Methods: Twenty-five ASD, preschool school-aged (2-10 years), were divided into three groups based on DSM-5 severity levels. The PEP-3 scale was used assess cognitive, language, motor, emotional, social, behavioral Ten underwent 3-month intervention, data collected longitudinally. A control group ten children, matched age, sex, diagnosis, did not receive intervention. 12-month follow-up is planned all participants. Results: exhibited diverse profiles. Type B subjects displayed more severe symptoms, while showed milder symptoms better language interpersonal skills. After improvements noted several For levels (hypo-reactivity), percentage individuals at medium increased from 44% 50%. hyper-reactivity, rose 30% 40%. improved, high abilities rising 20% 25%. Relational behaviors also saw gains, an increase 50% 55% medium-level behaviors. experimental demonstrated outcomes compared group, particularly Conclusions: Preliminary findings suggest that training improves integration, coordination, interaction Further research needed confirm long-term benefits.

Language: Английский

Citations

1

Prevalence of Motor Milestone Delays in Autistic Children DOI
Olivia M. Pokoski, Sarah M. Furnier, Ronald E. Gangnon

et al.

JAMA Pediatrics, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Importance Prior literature has explored the prevalence of motor impairments in autistic individuals, but estimates come from clinical, convenience, or small samples, limiting generalizability. Better understanding frequency milestone delays individuals could improve early identification and subsequently lead to earlier intervention better developmental outcomes. Objective To determine a population-based sample 8-year-old children evaluate if having is associated with an age at autism evaluation diagnosis. Design, Setting, Participants This cross-sectional study was conducted using Autism Developmental Disabilities Monitoring (ADDM) Network data between surveillance years 2000 2016. ADDM are population based drawn 17 sites across US. Data were analyzed October 2023 August 2024. Exposure Binary indicator documented health educational records. Main Outcomes Measures The primary outcome among children. Associations diagnosis evaluated linear regression. Covariates included site, year, number discriminators, intellectual disability, child sex, race ethnicity. Results Among 32 850 aged 8 identified by active surveillance, 23 481 (71.5%) met criteria for delays. A total 5973 (18.2%) female. In regression models, significantly (mean age, 43.65 months; 95% CI, 43.38-43.91) than without 51.64 51.22-52.06). After stratifying co-occurrence disability (ID), those delays, regardless ID. Conclusions Relevance highlights association these evaluation, even co-occurring Early public priority, assessing particularly increased likelihood being autistic, may facilitate leading more timely interventions

Language: Английский

Citations

1

Fewer children with autism spectrum disorder with motor challenges receive physical and recreational therapies compared to standard therapies: A SPARK data set analysis DOI
Anjana Bhat

Autism, Journal Year: 2023, Volume and Issue: 28(5), P. 1161 - 1174

Published: Aug. 22, 2023

Approximately 85% of children with autism spectrum disorder from the SPARK study receiving standard interventions such as speech-language and occupational therapies. In contrast, only 32%–13% received movement therapies physical recreational therapies, respectively. Little is known about how service receipt changes a function children’s motor difficulties. Parents completed online surveys to provide report their child’s difficulties using Developmental Coordination Disorder–Questionnaire well various child (speech-language therapy, applied behavioral analysis, social skill interventions, therapy) by location (at school, privately/in community, or both). While (occupational increased increasing risk severity, there continued be large disparities in therapy (37%–55%) (15%–19%) compared (85%–92%) across settings indicating clear unmet needs for specific services given that 88.3% this sample at difficulties/Developmental Disorder. fine- gross-motor subscale scores were fairly comparably affected yet therapy/recreational less versus therapy. These findings explain paucity activity programs individuals need experts receive appropriate access training work disorder. Lay Abstract There are provided (physical therapies) therapies). Children greater funding programs. Movement including PTs, adapted educators, community exercise/sports coaches/professionals basic, specialized, continuing education meet adults not providing early developmental school-based but also ensuring built environments general therapy/adapted

Language: Английский

Citations

17

Relationship between service receipt during the COVID‐19 pandemic and autistic children's multisystem outcomes and autism severity: A SPARK dataset analysis DOI Open Access
Jung‐Mei Tsai, Anjana Bhat

Autism Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Children with autism spectrum disorder (ASD) display a variety of core and co-occurring difficulties in social, communication, everyday functioning, cognitive, motor, language domains. Receiving combination services to accommodate needs autistic individuals is essential for improving their future outcomes. During the COVID-19 pandemic, reduced service access negatively impacted children's This study aimed examine relationship between receipt parental perceived outcomes children while accounting various demographic, child, factors. We utilized impact survey data from SPARK (N = 6067). Ordinal logistic regression analyses were used predict child Demographic, factors included prediction models. Service SLT, ABA, PT/OT, MED, MH associated PT/OT ABA predicted improvements domains social interaction, activity, overall severity; SLT contributed improved communication MED was worsening on all Younger age, males, higher family income, lower severity, function, cognitive delay, greater absence mental health issues Overall, are functional whereas also provide wholistic view affecting relationships during pandemic.

Language: Английский

Citations

0

Motor difficulties in children with neurodevelopmental conditions: a report from a cross-national study in Belgian and Italian children DOI
Evi Verbecque, Charlotte Johnson,

Gaia Scaccabarozzi

et al.

European Journal of Pediatrics, Journal Year: 2025, Volume and Issue: 184(2)

Published: Feb. 4, 2025

Language: Английский

Citations

0

Investigation of Electroencephalographic Aspects, Adaptive Features, and Clinical Phenotypes in a Group of Children with Autism—A Pilot Study DOI Creative Commons

A. Capisizu,

Leon Zăgrean,

Elena Poenaru

et al.

Clinics and Practice, Journal Year: 2025, Volume and Issue: 15(3), P. 50 - 50

Published: Feb. 27, 2025

(1) Background: Autism, as an important global problem that affects many phenotypically different individuals, is associated with electroencephalographic (EEG) abnormalities and adaptability impairment. (2) Materials Methods: In this retrospective study of a group 101 autistic children, we aimed to evaluate the presence EEG abnormalities, adaptive features, clinical phenotypes via EEG, Adaptive Behavior Assessment System II (ABAS II) scale, neurological examination. (3) Results: Our results showed statistically significant associations between level obtained through ABAS scale deficit, specifically in terms coordination There were also differences autism type groups. (4) Conclusions: This shows children are likely exhibit abnormalities. Non-invasive assessment tools, such recordings, examination offer valuable support for improved diagnosis management.

Language: Английский

Citations

0

Assessment of Hand Grip and Pinch Strengths in Children with Autism Spectrum Disorders: A Cross-Sectional Study DOI Creative Commons
Olfat Ibrahim Ali, Hassan Izzeddin Sarsak,

Malak Mohammed Tarshi

et al.

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 320 - 320

Published: March 1, 2025

Background/objective: Children with autism spectrum disorders (ASD) are recognized to experience challenges muscle function. However, there is a lack of knowledge about and hand grip strength in autism. Therefore, the study aims assess handgrip pinch ASD typical children. Material method: This enrolled 45 participants both sexes, 27 males 18 females, aged 6–12 years old; 24 (13 females 11 males) were typically developing children 21 (5 16 had ASD. The outcome measures strength, handheld dynamometer assessing hydraulic gauge evaluating grip. measured strengths key, tripod, pulp grips. Both groups assessed on their dominant non-dominant sides. Result: A comparison group control revealed that exhibited lower values grip, key pinch, tripod for hands (p < 0.05). Conclusions: than those evaluation process should include as standard component. Furthermore, rehabilitation program prioritize enhancing strength.

Language: Английский

Citations

0

Mapping Children’s Social and Motor Skill Profiles to Autistic Traits and Behavioral Tendencies DOI
Sara M. Scharoun Benson, Danielle Salters, Alex J. Benson

et al.

Journal of Autism and Developmental Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

Citations

0

Sensory–movement underpinnings of lifelong neurodivergence: getting a grip on autism DOI Creative Commons
Steven K. Kapp

Frontiers in Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 14, 2025

While the autism diagnosis emphasizes “deficits” in social communication, article advances that sensory–movement differences underpin through a review of following sources evidence. This account critically challenges “autistic regression”, with evidence features appear by birth as earliest signs and underlie behavioral used for diagnosis, which may reflect adaptations to inherent misunderstandings from others. Sensory motor are salient autistic people, but they often go underrecognized They cause cascading effects infancy on behavior communication sensorimotor learning, automatic imitation, eye contact, sensory perception, interests. The then explains how processing influence reduced perceptual narrowing, involves bottom-up information style grounded surrounding environment. Furthermore, this grow integration feedback loops potentially involving cerebellum brain. moves into implications widespread consequences these quality life. closes construct (including underestimated empathy pain), testing theory, providing sensory-sensitive support acceptance applications diverse people. theory apply particularly well women girls, people speech divergence, ADHD, co-occurring motor-related neurodivergences. Throughout article, also provides clinical, neurological, experiential lifelong, challenging notion “losing” (an) (diagnosis) instead reflecting (risky not necessarily “successful”) camouflaging.

Language: Английский

Citations

0