Cardiovascular health metrics and diabetic nephropathy: a nationally representative cross-sectional study DOI Creative Commons
Yanpei Mai, Si Yan, Liya Gong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Abstract Background: The pathogenesis of diabetic nephropathy is well-documented to be multifactorial. However, research available on the association between cardiovascular health and limited. Thus, this study aimed investigate these potential associations provide guidance for disease prevention. Methods: We applied Life's Essential 8 (LE8) identified by American Heart Association, which integrates multiple behaviors factors measure health. This covered 4,207 adults with diabetes from National Health Nutrition Examination Survey spanning 2007–2018. Weighted regression models assessed estimated effect LE8 score prevalence as well their corresponding clinical indicators. restricted cubic spline discussed possible nonlinear dose-response relationships further. Subgroup analyses clarified effects other covariates correlations. Results: After adjusting all covariates, participants moderate or high showed a decreased (odds ratio [OR]:0.52; 95% confidence interval [CI]:0.42 ~ 0.63), also decrease in urinary albumin-to-creatinine-ratio [UACR] (β:-0.83; CI:-1.00~-0.65). level UACR tended linearly total increased (P > 0.05). that overall specific construct varied across age obesity strata. Conclusions: Elevated was significantly associated lower U.S. adults, indicators varied. In all, maintaining good refining metrics may help reduce adverse effects.

Language: Английский

Prevalence of chronic kidney disease among Chinese adults with diabetes: a nationwide population-based cross-sectional study DOI Creative Commons
Weiping Jia,

Rong Yu,

Limin Wang

et al.

The Lancet Regional Health - Western Pacific, Journal Year: 2025, Volume and Issue: 55, P. 101463 - 101463

Published: Jan. 11, 2025

Language: Английский

Citations

1
Relationship between LE8 score and peripheral arterial disease from NHANES perspective DOI
Zhixian Liu, Zhi-Bo Zhang, Tianhua Li

et al.

VASA, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Summary: Background: This study examined the link between Life’s Essential 8 (LE8) metric and peripheral artery disease (PAD) prevalence in U.S. Patients methods: population-based prospective cohort analyzed data from 6,076 participants aged 20 years older National Health Nutrition Examination Survey (NHANES) conducted 1999 2004. LE8 scores were categorized into low, moderate, high cardiovascular health (CVH) levels. Multivariable weighted logistic regression subgroup analyses performed to examine relationship CVH PAD, adjusting for demographic clinical variables. Results: In final analysis, a total of individuals included, with mean age 59.41±12.80 51.3% (n=3,115) being male. The PAD was 6.9% (n=418). After confounding factors, compared low CVH, those moderate had 34% lower risk (OR: 0.66, 95% CI: 0.53–0.82), 62% 0.38, 0.25–0.58). Conclusions: conclusion, we report that are associated higher among adults. These findings may contribute prevention strategies PAD.

Language: Английский

Citations

0
Modifiable risk factors and plasma proteomics in relation to complications of type 2 diabetes DOI Creative Commons
Ruyi Li,

Shufan Tian,

Jun Liu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

A comprehensive assessment of combined modifiable risk factors with common complications type 2 diabetes (T2D) is lacking, and the potential role proteomics remains unclear. Here, we examine associations cardiovascular health (CVH) score degree factor control diabetic using data from UK Biobank (n = 14,102). Furthermore, explore mediation effects plasma in a subset proteomic 1287). Over median follow-ups 12.4–13.4 years, higher CVH are associated lower risks 30 22 45 adverse outcomes among individuals T2D, respectively. Mediation analyses reveal that mortality multiple vascular diseases share mediators, such as uromodulin pro-adrenomedullin. These findings highlight importance modification reducing disease burden people T2D facilitate understanding proteins underlying these associations. Risk crucial for care. authors show relationships provide further insights into mediating proteomics.

Language: Английский

Citations

0
Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank DOI Creative Commons
Peng Yu, Yuzhou Zhang, Ka Wai Kam

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2025, Volume and Issue: 66(4), P. 63 - 63

Published: April 22, 2025

This study aimed to investigate the correlation between cardiovascular health (CVH), evaluated through Life's Essential 8 (LE8) score, and risk of new-onset age-related macular degeneration (AMD). longitudinal analysis included 271,274 participants who were free both diseases AMD at baseline. The LE8 score was classified into three categories: low (<50 points), moderate (50 <80 high (≥80 with higher scores indicating better CVH. Cox proportional hazards models used explore relationships CVH incidence. Furthermore, population attributable (PAR%) calculated for each individual metric. During an average follow-up duration 10.9 years, a total 7468 (2.8%) cases documented. Individuals levels had 14% (hazard ratio [HR] = 0.86; 95% confidence interval [CI], 0.78-0.94) 23% (HR 0.77; CI, 0.69-0.86) reduced developing AMD, respectively. A linear dose-response relationship identified cumulative incidence AMD. Attaining optimal in all individuals could potentially avert 9.4% (95% 3.7%-15.1%) cases. Among metrics, ideal blood glucose pressure related reduction 3.3% 8.7% cases, Enhanced is significantly associated Promoting guideline might contribute prevention

Language: Английский

Citations

0
Cardiovascular health metrics and diabetic nephropathy: a nationally representative cross-sectional study DOI
Yanpei Mai, Si Yan, Liya Gong

et al.

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: June 5, 2024

Language: Английский

Citations

0
Cardiovascular health metrics and diabetic nephropathy: a nationally representative cross-sectional study DOI Creative Commons
Yanpei Mai, Si Yan, Liya Gong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Abstract Background: The pathogenesis of diabetic nephropathy is well-documented to be multifactorial. However, research available on the association between cardiovascular health and limited. Thus, this study aimed investigate these potential associations provide guidance for disease prevention. Methods: We applied Life's Essential 8 (LE8) identified by American Heart Association, which integrates multiple behaviors factors measure health. This covered 4,207 adults with diabetes from National Health Nutrition Examination Survey spanning 2007–2018. Weighted regression models assessed estimated effect LE8 score prevalence as well their corresponding clinical indicators. restricted cubic spline discussed possible nonlinear dose-response relationships further. Subgroup analyses clarified effects other covariates correlations. Results: After adjusting all covariates, participants moderate or high showed a decreased (odds ratio [OR]:0.52; 95% confidence interval [CI]:0.42 ~ 0.63), also decrease in urinary albumin-to-creatinine-ratio [UACR] (β:-0.83; CI:-1.00~-0.65). level UACR tended linearly total increased (P > 0.05). that overall specific construct varied across age obesity strata. Conclusions: Elevated was significantly associated lower U.S. adults, indicators varied. In all, maintaining good refining metrics may help reduce adverse effects.

Language: Английский

Citations

0