Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism DOI Open Access
Sonia Spinelli,

Zelle Humma,

Mirko Magnone

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 13 - 13

Published: Dec. 24, 2024

Abscisic acid (ABA) is a hormone with long evolutionary history, dating back to the earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely descendants, existed before separation plant and animal kingdoms, conserved role as signals regulating cell responses environmental challenges. In mammals, along anti-inflammatory neuroprotective function ABA, nanomolar ABA regulates metabolic response glucose availability by stimulating uptake in skeletal muscle adipose tissue via an insulin-independent mechanism increasing energy production also dissipation brown white adipocytes. Chronic intake micrograms per Kg body weight improves blood glucose, lipids, morphometric parameters (waist circumference mass index) borderline subjects for prediabetes syndrome. This review summarizes most recent vitro vivo data obtained involvement receptors LANCL1 LANCL2 hormone’s action, importance mammals’ endowment two distinct hormones governing availability. Finally, unresolved issues future directions clinical use diabetes discussed.

Language: Английский

Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity DOI
Alyssa Huang, Dabin Yeum, Letícia E. Sewaybricker

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 8, 2025

Language: Английский

Citations

0
Integrated multiomic profiling of tail adipose tissue highlights novel genes, lipids, and metabolites involved in tail fat deposition in sheep DOI Creative Commons

Yujing Xie,

Xin Li,

Huili Liang

et al.

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 3, 2025

Tail fat is important for fat-tailed or fat-rumped sheep to survive in harsh environments. However, the molecular mechanism underlying tail deposition remains unclear. In this study, we comprehensively characterized transcriptome, untargeted lipidome, and targeted metabolome profiles of adipose tissues from Large-tailed Han (long sheep) Hu (short sheep). We identified 183 differentially expressed genes (DEGs), 55 differential lipids (DLs) 17 metabolites (DMs) tails sheep. Among DEGs selected (Q values ≤ 0.05 and│Log2(FC)│≥ 0.5), 18 DEGs, such as UCP3, ELOVL7 GDF10, were directly associated with lipid metabolism via Gene Ontology (GO) analysis. Some genes, PPP3R1A, ADRA1, DSLC46A2, reportedly metabolism. A fold change ≥ 1.2 0.83 a P-value < set default threshold select DLs DMs. DLs, 36 phosphatidylcholines 9 phosphatidylethanolamines. The top six greatest differences content LPE (20:4) (up), PC (42:10) (42:8) (16:1/16:1) (down), (29:0) (32:2) (down). DMs related tricarboxylic acid cycle, D-glucose, cis-aconitic citric abundant enriched mainly ferroptosis, extracellular matrix (ECM)-receptor interaction, cGMP-PKG, calcium signaling pathways cardiomyopathy cycle. This study obtained lipidome long short tails. findings suggested that ELOVL7, UCP3 ECM-receptor interaction contributed difference deposition, biosynthesis cycle may affect results enhance our understanding tail.

Language: Английский

Citations

0
Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation DOI Creative Commons
Maycon Tavares Emílio-Silva, Vinícius Peixoto Rodrigues, M. Fioravanti

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 7, 2025

Obesity is a growing global epidemic associated with changes in the gut microenvironment and metabolic endotoxemia, which can exacerbate inflammatory processes. Citral (CT), monoterpene present essential oils, has been investigated for its anti-inflammatory, antioxidant, immunomodulatory properties. However, role modulating axis during alterations obesity remains unknown. In this study, we effects of CT on intestinal impairment induced by lipopolysaccharide (LPS) high-fat diet (HFD) vitro vivo models. Male C57BL/6J mice were fed standard HFD 17 weeks, daily oral administration treatment (25, 100, or 300 mg/kg) vehicle. Morphological histological parameters, lipid profiles, adipose index, cytokine levels, colonic gene expression determined. vitro, murine rectal carcinoma (CMT-93) cells stimulated LPS (10 μg/mL) to assess tight junction protein expression. showed anti-obesity activity against HFD-induced body mass gain mice, was attributed significant reduction fat, glycemia, cholesterol levels. Systemic inflammation also decreased after treatment, serum levels endotoxin, interleukin-1β, tumor necrosis factor-α. Additionally, stimulation reduced inducible nitric oxide synthase maintained ZO-1 LPS-stimulated CMT-93 cells. anti-obesogenic, anti-hyperlipidemic properties mediated protective epithelium obesity. Thus, our results highlight promising preclinical as agent detrimental mice.

Language: Английский

Citations

0
Health-enhancing physical activity in obesity management: the need to (seriously) go beyond weight loss DOI
Jean‐Michel Oppert, Cécile Ciangura, Alice Bellicha

et al.

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 49(2), P. 211 - 213

Published: Sept. 14, 2024

Language: Английский

Citations

3
Novel evidence of arsenic-related excess adiposity and its implication in the risk of cardiometabolic diseases DOI
Ahsanul Mahbub Jubayar,

Shuchismita Khan,

Junayed Sadi

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 271, P. 121059 - 121059

Published: Feb. 6, 2025

Language: Английский

Citations

0
Lipedema: A Disease Triggered by M2 Polarized Macrophages? DOI Creative Commons
Thomas Grewal, Sally Kempa, Christa Buechler

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 561 - 561

Published: Feb. 23, 2025

Background/Objectives: Lipedema is a progressive disease that results in the bilateral and symmetrical accumulation of subcutaneous fat legs and/or arms, affecting almost exclusively women. Methods: A comprehensive review peer-reviewed literature was conducted between November 2024 February 2025. Results: The pathophysiology lipedema complex and, especially early stages, shows similarities to obesity, involving adipocytes, adipose tissue-resident macrophages, endothelial cells. In lipedema, systemic levels adipocyte expression classical adipokines adiponectin leptin appear normal, while it remains unclear if markers inflammation oxidative stress are increased. Macrophages tissue patients have an anti-inflammatory M2 phenotype express high scavenger receptor CD163. These cells affect adipogenesis seem central role accumulation. Increased lymphatic blood vessel permeability comorbidities occur states may contribute progression. Conclusions: This summarizes our current understanding with focus on stromal vascular localized macrophages.

Language: Английский

Citations

0
Obesity and Obesity-Related Disorders—Editorial DOI Open Access
Grażyna Nowicka

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7954 - 7954

Published: July 21, 2024

Obesity and obesity-related complications, including various metabolic diseases cancers, are significant health problems in developed developing countries [...]

Language: Английский

Citations

2
The relevance of the heme oxygenase system in alleviating diabetes-related hormonal and metabolic disorders DOI Creative Commons
Tomasz Szkudelski, Katarzyna Szkudelska

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1871(1), P. 167552 - 167552

Published: Oct. 25, 2024

Language: Английский

Citations

1
Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism DOI Open Access
Sonia Spinelli,

Zelle Humma,

Mirko Magnone

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 13 - 13

Published: Dec. 24, 2024

Abscisic acid (ABA) is a hormone with long evolutionary history, dating back to the earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely descendants, existed before separation plant and animal kingdoms, conserved role as signals regulating cell responses environmental challenges. In mammals, along anti-inflammatory neuroprotective function ABA, nanomolar ABA regulates metabolic response glucose availability by stimulating uptake in skeletal muscle adipose tissue via an insulin-independent mechanism increasing energy production also dissipation brown white adipocytes. Chronic intake micrograms per Kg body weight improves blood glucose, lipids, morphometric parameters (waist circumference mass index) borderline subjects for prediabetes syndrome. This review summarizes most recent vitro vivo data obtained involvement receptors LANCL1 LANCL2 hormone’s action, importance mammals’ endowment two distinct hormones governing availability. Finally, unresolved issues future directions clinical use diabetes discussed.

Language: Английский

Citations

0