Cutaneous adverse reactions of COVID ‐19 vaccines: A systematic review

Dermatologic Therapy, Journal Year: 2022, Volume and Issue: 35(5)

Published: Feb. 23, 2022

Numerous vaccines are under clinical development and implementation for the prevention of severe course lethal outcomes coronavirus disease 2019 (COVID-19). This systematic review aims to summarize integrated findings studies regarding cutaneous side effects COVID-19 vaccines. conducted by searching scientific databases PubMed, Scopus, Science direct, Web knowledge from beginning May 10, 2021. Articles were reviewed analyzed based on Preferred Reporting Items Systematic Reviews Meta-Analyses checklist. Seventeen included after screening search results eligibility criteria. The showed that most common injection site reactions delayed large local reactions, arising all vaccine types, redness/erythema (39%), followed by: itchiness (28%), urticarial rash (17%) neck, upper limbs, trunk, morbilliform eruptions (6.5%), Pityriasis rosea (3%), swelling, burning, so forth. Most occurred in women (84%), middle-aged people, first dose vaccine, with onset ranged 1 21 days vaccination. In addition, generally self-limiting, needed little or no therapeutic intervention, not regarded as a barrier injecting second dose. conclusion, very rare approved have satisfactory safety profiles. Therefore, mild moderate should discourage people certain groups such patients allergies history pre-vaccination counseling assurance, also use appropriate medications may be helpful. However, more investigate effect profile

Language: Английский

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Sex and gender differences in adverse events following influenza and COVID-19 vaccination

Biology of Sex Differences, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 18, 2024

Abstract Introduction Active and passive surveillance studies have found that a greater proportion of females report adverse events (AE) following receipt either the COVID-19 or seasonal influenza vaccine compared to males. In predominately young adult female population healthcare workers, we sought determine intersection biological sex sociocultural gender differences in prospective active reporting outcomes, which remains poorly characterized. Methods This cohort study enrolled Johns Hopkins Health System workers (HCWs) who were recruited from mandatory annual fall 2019–2022 2022 bivalent campaigns. Vaccine recipients day vaccination AE surveys administered two days post-vaccination for recipients. Data collected regarding presence series solicited local systemic AEs. Open-ended answers about participants’ experiences with AEs also Results Females more likely after (OR = 2.28, p 0.001) 2.57, 0.008) males, regardless age race. Males had comparable probabilities 1.18, 0.552) 0.96, 0.907) vaccination. Hormonal birth control use did not impact rates reported among reproductive-aged HCWs. Women interruptions their daily routine than men seek out self-treatment. More women scheduled before off anticipation Conclusions Our findings highlight need sex- gender-inclusive policies inform effective occupational health strategies. Further research is needed evaluate potential disruption on responsibilities mandated population, fully characterize behavioral between women.

Language: Английский

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Cutaneous reactions to vaccination

JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Summary Vaccination is a fundamental principle of preventive health care. Administration the vaccine, which contains antigen(s) pathogen, activates immune system and provides protection against infection. The immunogenicity allergenicity vaccine may lead to various adverse reactions, depending on responsiveness susceptibility vaccinated individual. Cutaneous events are among most common can manifest as local or generalized vaccination reactions. Understanding their pathogenesis clinical manifestations essential for therapy, further diagnostic clarification if necessary, managing any booster that be required. Appropriate dermatological expertise therefore plays crucial role in patients with history

Language: Английский

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Kutane Impfreaktionen

JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2025, Volume and Issue: 23(2), P. 195 - 210

Published: Feb. 1, 2025

Zusammenfassung Impfungen sind ein grundlegendes Prinzip der Gesundheitsvorsorge. Durch Applikation des Impfstoffs, Antigen(e) eines Erregers enthält, kommt es zur Aktivierung Immunsystems mit Aufbau Infektionsschutzes. Je nach Immunogenität und Allergenität Impfstoffs kann in Abhängigkeit von Reaktivität Suszeptibilität geimpften Individuums zu unterschiedlichen unerwünschten Reaktionen kommen. Kutane Nebenwirkungen gehören hierbei den häufigsten können sich verschiedenen lokalen oder generalisierten Impfreaktionen äußern. Das Wissen um deren Pathogenese klinische Erscheinungsformen ist essentiell Hinblick auf Therapie, gegebenenfalls weitere diagnostische Abklärung dem Vorgehen bei einer eventuell erforderlichen Auffrischungsimpfung. Entsprechendes dermatologisches Fachwissen spielt daher eine entscheidende Rolle im Management Patienten anamnestischen Impfreaktionen.

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Cutaneous Adverse Events Following COVID-19 Vaccination in Japan: A Questionnaire Survey

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

We conducted a nationwide survey in Japan to clarify the clinical spectrum of these events. An initial questionnaire was sent 126 dermatology facilities, and responses were obtained from 66 (52.4%). Among responding most commonly identified cutaneous adverse events after COVID-19 vaccination urticaria (49 (74.2%)), delayed local reactions (37 (56.1%)), erythema multiforme (31 (47.0%)), alopecia (30 (45.5%)). The primary (19 (20.9%)), bullous pemphigoid (7 (7.7%)), (6 (6.6%)). mean latency onset 13.1 days, duration symptoms 74.2 days. Although this study cannot establish direct causal relationship between events, it highlights need for dermatologists recognize potential provide appropriate care.

Language: Английский

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Papuloerythroderma of Ofuji Associated with Elevated Varicella-zoster Virus Complement-fixing Antibody Titers Following BNT162b2 mRNA COVID-19 Vaccination

Acta Dermato Venereologica, Journal Year: 2025, Volume and Issue: 105, P. adv42546 - adv42546

Published: April 2, 2025

Language: Английский

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Global incidence pattern and factors associated with common cutaneous reactions related to COVID-19 vaccination of 2.55 million participants in real-world settings: A systematic review and meta-analysis

Journal of Global Health, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 9, 2023

Understanding the incidence pattern of cutaneous reactions is crucial for promoting COVID-19 vaccination. We aimed to report global of, and factors associated with common related vaccination in real-world settings.We searched five databases (PubMed, Web Science, Embase, CNKI, Wanfang) from inception May 13, 2022, studies reporting vaccines settings. The outcomes were systematic skin (rash urticaria) local injection site (pain, swelling, redness, erythema). conducted random-effects meta-analyses explored using multi-step statistical analyses.We included 35 assessed 2 549 968 participants 23 countries. pooled overall systemic was 3.8% (95% confidence interval (CI) = 2.4%-5.5%) short duration (about one week). Specifically, rates rash urticaria 3.0% CI 2.1%-3.9%) 1.1% 0.7%-1.5%), respectively. For reactions, 72.4% 65.7%-78.7%) (1 4.5 days). Except pain (72.2%, 95% 65.3%-78.5%), other localized had low incidence, including swelling (13.3%, 9.5%-17.7%), redness (11.5%, 5.7%-19.0%), erythema (5.8%, 0.7%-15.4%). Geographically, different distribution patterns observed these reactions. Regarding factors, mRNA showed lower (P < 0.001). Asia population higher among inactivated found no significant difference between first second dose vaccines.We examined (except pain); discrepancies across vaccine types. side effects do not seem cause concern.PROSPERO: CRD42021258012.

Language: Английский

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Alopecia areata following COVID-19 vaccine: a systematic review

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: July 5, 2024

Abstract Background To date, multiple cases of adverse reactions to COVID-19 vaccines have been reported worldwide. Alopecia areata (AA) is an uncommon type reaction in some articles and has a significant social psychological impact on patients. Our study aimed review the AA vaccine literature. Methods This systematic was conducted by searching for following international databases such as Embase, MEDLINE, PubMed, Web Knowledge, Ovid from December 2019 30, 2023. We included studies that provided data patients vaccination with at least one dose. Data sex, age, country/region origin, type, days between symptom presentation, manifestations AA, trichoscopy histopathological findings, treatment, outcomes were included. Results In total, 579 explored identified assessed, 25 total 51 review. Twenty-seven (52.9%) developed new-onset receiving vaccine, recurrence or exacerbation occurred after 24 (47.1%) preexisting disease. Five cause all cases. The Pfizer (45.1%) most frequently reported, followed ChAdOx1 nCoV-19 (27.5%), Moderna mRNA-1273 (19.6%), Sinopharm (3.9%) SinoVac (3.9%). within month 1st dose, then, incidence decreased gradually time. Topical systemic corticosteroids used 38 Eleven treated Janus Kinase inhibitor (jakinib) inhibitor, eight tofacitinib, three unspecified jakinib. However, 3 11 experienced exacerbations treatment. Conclusion rare, physicians should be aware this phenomenon improve early diagnosis appropriate

Language: Английский

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Teledermatology for Common Inflammatory Skin Conditions: The Medicine of the Future?

Life, Journal Year: 2023, Volume and Issue: 13(4), P. 1037 - 1037

Published: April 18, 2023

Background: The COVID-19 pandemic period revolutionized daily clinical practice. Several strategies were adopted by clinicians to avoid reducing treatment for diseases without the risk of spreading infection. Among strategies, telemedicine played a key role. In this scenario, several tools used, including e-mails, phone calls, video support groups, and messages. Fortunately, seems be at an end. However, use teledermatology appears excellent strategy future as well. Indeed, patients may benefit from teledermatology. Objective: manuscript, we aim investigate in dermatological field point out how tool become mainstay medicine. Only with common inflammatory skin conditions have been reported herein. Materials Methods: Investigated manuscripts included metanalyses, reviews, letters editor, real-life studies, case series, reports. Manuscripts identified, screened, extracted relevant data following PRISMA (preferred reporting items systematic reviews meta-analyses) guidelines. Results: A total 121 records identified analyzed databases. only 110 articles assessed eligibility. Finally, 92 selected end literature research our review. Conclusions: Teledermatology should considered viable option dermatologist future. We believe that has strengthened service, will allow ever better development Guidelines regarding are required well additional improvements

Language: Английский

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Cutaneous reactions following COVID‐19 vaccination assessed by dermatologists: a single‐institutional study in Germany

JDDG Journal der Deutschen Dermatologischen Gesellschaft, Journal Year: 2023, Volume and Issue: 21(3), P. 255 - 262

Published: March 1, 2023

Summary Background and objectives Cutaneous reactions following COVID‐19 vaccination have been frequently described, whereas larger case series by dermatologists are lacking. This study assesses SARS‐CoV‐2 vaccination‐associated skin reactions, severity, treatment, course, eliciting vaccines, allergy test results tolerance to revaccination. Patients methods Single‐institutional, non‐interventional of assessing cutaneous manifestations in 83 patients Germany. Results 93 were presented. Manifestations clustered into immediate (n = 51, 54.8%) delayed hypersensitivity 10, 10.8%), chronic inflammatory diseases 13, 14.0%), reactivation latent herpes virus infection (pityriasis rosea/herpes zoster; n 9; 9.7%) others 10.8%). Vaccination was associated with new (76.3%) – mostly or exacerbation known (23.7%), this predominantly diseases. Reactions occurred primarily within the first week (72.8%) after (62.0%). Treatment required 83.9% hospitalization 19.4%. In 48.8% revaccination led recurrence same reactions. Disease ongoing at last consultation 22.6%, Allergy tests performed 15 (18.1%) resulted negative. Conclusions It can be assumed that may trigger immune activation‐related especially those predisposed develop respective

Language: Английский

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