Paracetamol Use and COVID-19 Clinical Outcomes: A Meta-Analysis

Healthcare, Journal Year: 2024, Volume and Issue: 12(22), P. 2309 - 2309

Published: Nov. 19, 2024

During the COVID-19 pandemic, paracetamol was widely recommended in different clinical settings, and sometimes advised over non-steroidal anti-inflammatory drugs (NSAIDs). These recommendations sparked a strong debate, with reports suggesting either potential benefits or harms for individuals infected SARS-CoV-2. As no systematic review is available, we performed meta-analysis to estimate impact of on outcomes compared placebo, use, NSAIDs.

Language: Английский

Vaccine Hesitancy and Associated Factors Amongst Health Professionals: A Scoping Review of the Published Literature

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1411 - 1411

Published: Dec. 13, 2024

Background/Objectives: Healthcare professionals (HCPs) hold significant influence over public attitudes toward vaccinations. Studies suggest that HCPs are hesitant towards the coronavirus disease 2019 (COVID-19) vaccines. This hesitancy could lead to lower vaccination rates in community. Therefore, this scoping review aimed assess extent of COVID-19 booster doses among and identify associated factors. Methods: A comprehensive search was conducted PubMed Scopus databases from April August 2024, using keywords related COVID-19, vaccine hesitancy, HCPs, vaccination. had been peer-reviewed, published English after 2022, focused on dose were included. Out 6703 studies screened, 24 Results: Most have received their initial series However, there is a rate uptake for doses, with ranging 12% 66.5%. Hesitancy varied significantly across continents, Asia, Africa, Europe 19.7% 66.5%, 27% 46.1%, 14% 60.2%, respectively. reported be influenced by various factors, including concerns about safety, necessity, effectiveness these In addition, regarding also found factors like age, gender, profession, previous COVID-19. Physicians, nurses, pharmacists exhibited 12.8% 43.7%, 26% 37%, 34.6%, Conclusions: Our underscores receiving countries around world explores underlying These findings provide valuable insights design future pandemic programs.

Language: Английский

Immunologic and Biophysical Features of the BNT162b2 JN.1- and KP.2-Adapted COVID-19 Vaccines

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT Vaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched circulating SARS-CoV-2 lineages elicit potent and relevant immune responses translate improved real-world vaccine effectiveness. The rise in prevalence Omicron JN.1 lineage, subsequent derivative sublineages such as KP.2 KP.3, coincided with reduced neutralizing activity effectiveness XBB.1.5-adapted vaccines. Here, we characterized biophysical immunologic attributes BNT162b2 JN.1- KP.2-adapted mRNA vaccine-encoded spike (S) protein immunogens. Biophysical interrogations S revealed structural consequences hallmark amino acid substitutions potential molecular mechanism escape employed by KP.2. candidates were evaluated for their immunogenicity when administered fourth or fifth doses BNT162b2-experienced mice primary series naïve mice. In both vaccine-experienced settings, conferred over XBB.1.5 against broad panel emerging sublineages, including predominant KP.3.1.1 XEC lineages. Antigenic mapping indicated greater antigenic overlap currently compared an vaccine. CD4 + CD8 T cell generally conserved across all three Together, data support selection 2024-25 formula. ONE-SENTENCE SUMMARY encoding prefusion proteins similar preclinical antibody sublineage pseudoviruses than those elicited past iterations licensed vaccines, thus demonstrating importance annual strain changes

Language: Английский