Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging

Nutrients, Journal Year: 2019, Volume and Issue: 11(3), P. 504 - 504

Published: Feb. 27, 2019

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects against redox stress by providing reducing equivalents to antioxidants such as glutathione and thioredoxin. NADPH levels decline with aging in several tissues, but whether this is a major driving force for the process has not been well established. Global or neural overexpression cytoplasmic enzymes that synthesize have shown extend lifespan model organisms Drosophila suggesting positive relationship between longevity. Mitochondrial plays an important role protection cell death mitochondrial NADPH-utilizing thioredoxin reductase 2 correlate species longevity cells from rodents primates. shuttles allow some flux cytoplasm mitochondria. Since (NAD+) linked because NADP+ exclusively synthesized NAD+ kinases, pool may also contribute process. Therefore pro-longevity therapies should aim maintain both tissues.

Language: Английский

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Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A Review

Antioxidants, Journal Year: 2020, Volume and Issue: 9(10), P. 937 - 937

Published: Sept. 29, 2020

The astronomical increase of the world’s aged population is associated with increased prevalence neurodegenerative diseases, heightened disability, and extremely high costs care. Alzheimer’s Disease (AD) a widespread, age-related, multifactorial disease that has enormous social financial drawbacks worldwide. unsatisfactory outcomes available AD pharmacotherapy necessitate search for alternative natural resources can target various underlying mechanisms pathology reduce occurrence and/or progression. Royal jelly (RJ) main food bee queens; it contributes to their fertility, long lifespan, memory performance. It represents potent nutraceutical pharmacological properties, been used in number preclinical studies age-related cognitive deterioration. To understand through which RJ affects performance both aging AD, we reviewed literature, elaborating on metabolic, molecular, cellular mediate its anti-AD effects. Preclinical findings revealed acts as multidomain enhancer restore models. promotes brain cell survival function by targeting multiple adversities neuronal microenvironment such inflammation, oxidative stress, mitochondrial alterations, impaired proteostasis, amyloid-β toxicity, Ca excitotoxicity, bioenergetic challenges. Human trials using are limited quantity quality. Here, limitations RJ-based treatment strategies discussed, directions future examining effect cognitively subjects noted.

Language: Английский

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Longitudinal change of sleep timing: association between chronotype and longevity in older adults

Chronobiology International, Journal Year: 2019, Volume and Issue: 36(9), P. 1285 - 1300

Published: July 22, 2019

Evening-oriented sleep timing preferences have been associated with risk of diabetes, cardiovascular diseases, obesity, psychiatric disorders, and increased mortality. This research aims to explore the relationship between diurnal (chronotype), daily habits, metabolic health, mortality, using longitudinal data from The University Manchester Longitudinal Study Cognition in Normal Healthy Old Age (6375 participants at inception, recruited North England) a long follow-up period (up 35.5 years). Mixed models were used investigate influence aging, socio-demographic, seasonal factors on timing. Results show that shifted towards earlier time aging. Test seasons chronotype older adults but working schedules challenge seasonality Moreover, season birth may set adulthood. Individual trajectories clustered latent class analysis analyzed against health We observed higher hypertension evening-type cluster compared morning-type individuals (Odds ratio = 1.88, 95%CI 1.02/3.47, p .04). Evening-type was also traits related lower such as reduced sport participation, depression psychoticism personality, late eating, smoking alcohol usage. Finally, Cox regression proportional hazards study effects longevity after adjusting for duration, age, gender, smoking, usage, general social class. survival (82.6% censored by death) revealed likelihood mortality (Hazard 1.15, 1.04/1.26, .005). Taken together, is influenced aging effects. preference detrimental outcomes human well-being longevity.

Language: Английский

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Interacting influences of aging and Alzheimer's disease on circadian rhythms

European Journal of Neuroscience, Journal Year: 2019, Volume and Issue: 51(1), P. 310 - 325

Published: Jan. 28, 2019

Abstract Aging leads to changes in circadian rhythms, including decreased amplitude or robustness, altered synchrony with the environment, and reduced coordination of rhythms within body. These rhythm alterations are more pronounced age‐associated neurodegenerative disorders such as Alzheimer's disease ( AD ), which they often precede onset other symptoms by many years. As well their early onset, findings that fragmentation daily rest‐activity non‐demented older subjects is associated earlier cognitive decline, increased risk incident , preclinical neuropathology, suggest disruption may contribute development progression neuropathological occurring . Conversely, studies have implicated amyloid‐beta, a prominent neurotoxin accumulates impairment rhythms. Thus, ‐associated neurodegeneration interact form deleterious cycle. This article reviews neural molecular mechanisms underlying age‐ ‐related It also explores therapeutic strategies proposed ameliorate deficits elderly demented individuals.

Language: Английский

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Longitudinal sleep efficiency in the elderly and its association with health

Journal of Sleep Research, Journal Year: 2019, Volume and Issue: 29(3)

Published: July 16, 2019

Abstract The relationships between older age and sleep efficiency have traditionally been assessed using cross‐sectional studies that ignore changes within individuals as they age. This research examines the determinants of efficiency, heterogeneity in an individual's trajectory across a period up to 27 years later life its associations with health. University Manchester Longitudinal Study Cognition Normal Healthy Old Age cohort ( n = 6,375; 42–94 years) was used this study. Depression health data were collected self‐report validated instruments (Cornell Medical Index, Beck Inventory Geriatric Scale). sociodemographic study‐specific questionnaire. A mixed‐effect model performed for adjustments time‐invariant time‐variant predictors. Latent class analysis demonstrate subgroups trajectories clusters history participants investigated. Older adults decreased over time, 18.6% decline 40 100 Three identified: high (32%), medium (50%) low (18%). Belonging cluster associated having lower prevalence hypertension, circulatory problems, general arthritis, breathing problems recurrent episodes depression compared cluster. Overall, ageing decreases efficiency. However, there are detectable related different diseases.

Language: Английский

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Alternative model organisms for toxicological fingerprinting of relevant parameters in food and nutrition

Critical Reviews in Food Science and Nutrition, Journal Year: 2021, Volume and Issue: 62(22), P. 5965 - 5982

Published: March 8, 2021

In the field of (food) toxicology, there is a strong trend replacing animal trials with alternative methods for assessment adverse health effects in humans. The replacement not only driven by ethical concerns but also number potential testing substances (food additives, packaging material, contaminants, and toxicants), which steadily increasing. vitro 2D cell culture applications combination silico modeling might provide an applicable first response. However, those systems lack accurate predictions metabolic actions. Thus, vivo models could fill gap between trials. this review, we highlight relevant studies spotlight applicability models, including C. elegans, D. rerio, Drosophila, HET-CAM Lab-on-a-chip.

Language: Английский

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Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy

Neuroscience & Biobehavioral Reviews, Journal Year: 2019, Volume and Issue: 98, P. 122 - 134

Published: Jan. 9, 2019

Language: Английский

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The CBP KIX domain regulates long-term memory and circadian activity

BMC Biology, Journal Year: 2020, Volume and Issue: 18(1)

Published: Oct. 29, 2020

Abstract Background CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain that binds numerous factors potentially affecting expression of thousands genes. Identifying specific domain functions proteins essential to understand processes such as cognitive function and circadian clocks. We investigated the CBP KIX in hippocampal gene using KIX/KIX mice mutations prevent phospho-CREB (Ser133) binding. Results found were impaired memory, but not learning acquisition or short-term Morris water maze. Using an unbiased analysis dorsal hippocampus after training maze contextual fear conditioning, we discovered dysregulation CREB, CLOCK, BMAL1 target genes downregulation mice. Given our finding was important genes, profiled activity phase resetting exhibited delayed peaks light offset longer free-running periods constant dark. Interestingly, displayed delays advances response photic stimulation comparable wildtype littermates. Thus, this work delineates site-specific regulation clock protein. Conclusions These studies provide insight into significance defining targets transcriptional co-activation role vivo on rhythms. Graphical abstract

Language: Английский

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Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(17), P. 10032 - 10032

Published: Sept. 2, 2022

Circadian rhythm is associated with the aging process and sex differences; however, how age can change circadian regulation systems remains unclear. Thus, we aimed to evaluate age- sex-related changes in gene expression identify sex-specific target molecules that regulate aging. Rat livers were categorized into four groups, namely, young male, old female, of several genes involved was confirmed by silico vitro studies. Gene Ontology Kyoto Encyclopedia Genes Genomes pathway enrichment analyses showed related rhythms changed more males than females during liver In addition, differentially expressed analysis quantitative real-time polymerase chain reaction/western blotting revealed Nr1d1 Nr1d2 upregulated Furthermore, other genes, such as Arntl, Clock, Cry1/2, Per1/2, Rora/c, decreased aging; these various patterns Age-related elevation Nr1d1/2 downregulates males, but not females, Consequently, age-related upregulation may play a crucial role

Language: Английский

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Impacts of aging on circadian rhythm and related sleep disorders

Biosystems, Journal Year: 2023, Volume and Issue: 236, P. 105111 - 105111

Published: Dec. 28, 2023

Language: Английский

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