Sex and estradiol effects in the rodent dorsal striatum DOI Creative Commons
Valerie J. Lewitus, Jaekyoon Kim, Kim T. Blackwell

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract 17β‐Estradiol (E2) is a sex hormone that acts on many brain regions to produce changes in neuronal activity and learning. A key region sensitive E2 the dorsal striatum (also called caudate‐putamen), which controls motor behaviour, goal‐directed learning habit In adult rodents, oestrogen receptors (ERs) are localized plasma membrane include ERα, ERβ G protein‐coupled ER (GPER). E2, either naturally produced or exogenously applied, may influence excitability, basal synaptic transmission long‐term potentiation. These effects be due direct action signalling pathways dopamine availability. particular, estradiol influences release, receptor expression transporter expression. We review cellular has striatum, distinguishing between applied oestrous cycle, as well its striatal‐dependent behaviour.

Language: Английский

Extrinsic and intrinsic control of striatal cholinergic interneuron activity DOI Creative Commons

Desh Deepak Ratna,

T. Chase Francis

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Feb. 13, 2025

The striatum is an integrated component of the basal ganglia responsible for associative learning and response. Besides presence most abundant γ -aminobutyric acid (GABA-ergic) medium spiny neurons (MSNs), also contains distributed populations cholinergic interneurons (ChIs), which bidirectionally communicate with many these neuronal subtypes. Despite their sparse distribution, ChIs provide largest source acetylcholine (ACh) to striatal cells, have a prominent level arborization activity, are potent modulators output play roles in plasticity underlying reinforcement. Deviations from this tonic including phasic bursts or pauses caused by region-selective excitatory input, neuromodulator, neuropeptide release can exert strong influences on intrinsic activity synaptic via diverse receptor signaling. Recent studies new tools allowed improved identification factors driving suppressing peptides. This review aims outline our current understanding that control ChI specifically focusing how neuromodulators neuropeptides interact facilitate suppress responses plasticity.

Language: Английский

Citations

0
Nicotine is an immunosuppressant: Implications for Women's health and disease DOI
Ashley M. White, Ashley Craig,

Daryl L Richie

et al.

Journal of Neuroimmunology, Journal Year: 2024, Volume and Issue: 397, P. 578468 - 578468

Published: Oct. 20, 2024

Language: Английский

Citations

1
Pup defence in lactating rats: The underlying neuropeptide signalling and their interactions in the nucleus accumbens shell DOI Creative Commons
Alice Sanson, Luisa Demarchi,

A Köck

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Maternal aggression is a core feature of rodent maternal behaviour to defend their offspring from potential threats and modulated by corticotropin-releasing factor (CRF) oxytocin (OXT) systems signalling. Here, we investigated the involvement those neuropeptide in within nucleus accumbens shell (NAcSh), central region reward circuits. Infusion CRF or Urocortin3 (CRF-receptor 2 agonist), as well an OXT receptor antagonist, reduced aggression, suggesting role pup defence. Furthermore, effects infusion NAcSh continued beyond defence test (MDT), reducing nursing increasing self-grooming. Corroborating stress system colocalization cFos immunoreactive cells were increased response MDT, regardless presence. In addition, MDT exposure intra-NAc release lactating rats, which could be also triggered local retrodialysis CRF, but not Urocortin3. However, both ligands elicited dopamine (DA) different dynamics. Crh-r1 predominantly expressed medial NAc on medium-sized spiny neurons (MSN), rostral part GABAergic interneurons. Crh-r2 mainly its expression interneurons towards caudal pole. Lastly, identified CRF-enriched projections descending prefrontal cortex, amygdala, paraventricular thalamus, among others. conclusion, intra-NAcSh dampened activity enhanced transmission are indispensable for successful Any perturbations like signalling might activate compensatory mechanisms ensure adequate behaviour.

Language: Английский

Citations

1
Sex and estradiol effects in the rodent dorsal striatum DOI Creative Commons
Valerie J. Lewitus, Jaekyoon Kim, Kim T. Blackwell

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract 17β‐Estradiol (E2) is a sex hormone that acts on many brain regions to produce changes in neuronal activity and learning. A key region sensitive E2 the dorsal striatum (also called caudate‐putamen), which controls motor behaviour, goal‐directed learning habit In adult rodents, oestrogen receptors (ERs) are localized plasma membrane include ERα, ERβ G protein‐coupled ER (GPER). E2, either naturally produced or exogenously applied, may influence excitability, basal synaptic transmission long‐term potentiation. These effects be due direct action signalling pathways dopamine availability. particular, estradiol influences release, receptor expression transporter expression. We review cellular has striatum, distinguishing between applied oestrous cycle, as well its striatal‐dependent behaviour.

Language: Английский

Citations

0