Update on Parkinson’s Disease Rehabilitation DOI Creative Commons
Seo Yeon Yoon

Brain & Neurorehabilitation, Journal Year: 2022, Volume and Issue: 15(2)

Published: Jan. 1, 2022

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Although dopaminergic drugs are mainstay for improving PD symptoms, there still few effective disease-modifying therapies. With increasing prevalence of and rapid transition to an aging society, more emphasis needs be placed on rehabilitation that could slow progression combined with pharmacological therapy. In this review, we present update evidence related programs motor function, swallowing difficulty, speech disorders in PD. Aerobic exercise, music therapy, dance, virtual reality, non-invasive brain stimulation have been shown improve telerehabilitation also feasibly applied Recent studies effectiveness expiratory muscle strengthening exercises Lee Silverman Voice Treatment difficulty disorders, respectively. many tried, limited. Well-designed future randomized controlled trials large numbers participants needed establish

Language: Английский

Physical Rehabilitation of Patients with Parkinson’s Disease DOI
Erwin E. H. van Wegen, Marc B. Rietberg, Tim Vanbellingen

et al.

Cambridge University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 238 - 251

Published: Jan. 7, 2025

Language: Английский

Citations

0
Coordinated speech therapy, physiotherapy, and pharmaceutical care telehealth for people with Parkinson disease in rural communities: an exploratory, 8-week cohort study for feasibility, safety, and signal of efficacy DOI Creative Commons

Cooley Hidecker,

Landers,

Piccorelli

et al.

Rural and Remote Health, Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 13, 2022

The potential for coordinated, multidisciplinary telehealth to help connect people with Parkinson disease (PD) in rural areas PD specialists is crucial optimizing care. Therefore, this study aimed test the feasibility, safety, and signal of efficacy a coordinated program, consisting speech therapy, physiotherapy, pharmaceutical care, living some US communities.Fifteen individuals Wyoming Nevada, USA, participated single-cohort, 8-week pilot study. Participants were assessed before after 8 weeks one-on-one using following outcomes: (1) feasibility: session attendance withdrawal rate; (2) safety: adverse events; (3) efficacy: Communication Effectiveness Survey, acoustic data (intensity, duration, work (intensity times duration)), Parkinson's Fatigue Scale, 30 second Sit-to-Stand test, Disease Questionnaire - 39, Movement Disorder Society Unified Rating Scale Part III, medication adherence.Average was greater than 85% all participants. There no serious events only nine minor during treatment sessions (0.9% had participant report an event); cases resolved without medical attention. Although 14 16 outcomes effect sizes trending direction improvement, two statistically significant non-parametric analyses: (pre-test median=11.0 (interquartile range (IQR)=6.0); post-test median=12.0 (IQR=3.0) median=756.0 dB s (IQR=198.4); median=876.3 (IQR=455.5), p<0.05.A program safe feasible communities who have PD. This also yielded most measured

Language: Английский

Citations

15
A survey of technologies for automatic Dysarthric speech recognition DOI Creative Commons
Zhaopeng Qian,

Kejing Xiao,

Chongchong Yu

et al.

EURASIP Journal on Audio Speech and Music Processing, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Nov. 11, 2023

Abstract Speakers with dysarthria often struggle to accurately pronounce words and effectively communicate others. Automatic speech recognition (ASR) is a powerful tool for extracting the content from speakers dysarthria. However, narrow concept of ASR typically only covers technologies that process acoustic modality signals. In this paper, we broaden scope generalized dysarthric speech. Our survey discussed systems encompassed processing, articulatory movements processing audio-visual fusion in application recognizing Contrary previous surveys on recognition, have conducted systematic review advancements field. particular, introduced state-of-the-art supplement recent research during era multi-modality recognition. found perform better than traditional task training models requires more computing resources, available data corpus limited. Despite these challenges, show promising potential further improving accuracy future.

Language: Английский

Citations

8
Short-term effects of transcranial direct current stimulation on motor speech in Parkinson’s disease: a pilot study DOI Creative Commons
Luboš Brabenec, Daniel Kováč, Jiří Mekyska

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(7), P. 791 - 797

Published: April 9, 2024

Abstract Introduction: Hypokinetic dysarthria (HD) is a common motor speech symptom of Parkinson’s disease (PD) which does not respond well to PD treatments. We investigated short-term effects transcranial direct current stimulation (tDCS) on HD in using acoustic analysis speech. Based our previous studies we focused the right superior temporal gyrus (STG) - an auditory feedback area. Methods: In 14 patients with HD, applied anodal, cathodal and sham tDCS STG cross-over design. A protocol consisting tasks was performed prior immediately after each session. Linear mixed models were used for evaluation condition relative change parameters. also simulation mean electric field induced by tDCS. Results: model showed statistically significant effect median duration silences longer than 50 ms ( p = 0.015). The anodal (mean -5.9) significantly lower as compared 12.8), 0.014. found correlation between magnitude improvement articulation precision R 0.637; 0.019). Conclusions: exploratory study that over area may lead shorter pauses patients.

Language: Английский

Citations

2
Speech and neuroimaging effects following HiCommunication: a randomised controlled group intervention trial in Parkinson’s disease DOI Creative Commons
Hanna Steurer, Franziska Albrecht, Joakim Körner Gustafsson

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(4)

Published: Jan. 1, 2024

Abstract Speech, voice and communication changes are common in Parkinson's disease. HiCommunication is a novel group intervention for speech Parkinson’s disease based on principles driving neuroplasticity. In randomized controlled trial, 95 participants with were allocated to or an active control intervention. Acoustic analysis was performed pre-, post- six months after Intention-to-treat analyses missing values imputed linear multilevel models complimentary per-protocol performed. The proportion of clinically relevant increase the primary outcome measure sound level calculated. Resting-state functional MRI pre- post-intervention. Spectral dynamic causal modelling parametric empirical Bayes methods applied resting-state data describe effective connectivity speech-motor-related network brain regions. From post-intervention, there significant group-by-time interaction effects measures text reading (unstandardized b = 2.3, P 0.003), monologue 2.1, 0.009), Voice Quality Index −0.5, 0.016) Harmonics-to-Noise Ratio 1.3, 0.014) For 59% participants, relevant. There no sustained at six-month follow-up. analysis, decrease inhibitory self-connectivity left supplementary motor area increased from right paracentral gyrus compared conclusion, showed promising quality people disease, motivating investigations barriers facilitators implementation healthcare settings. altered following areas implicated, possibly due reorganization networks.

Language: Английский

Citations

2
P2X4R Overexpression Upregulates Interleukin-6 and Exacerbates 6-OHDA-Induced Dopaminergic Degeneration in a Rat Model of PD DOI Creative Commons

Jiangnan Ma,

Jinzhao Gao,

Mengyue Niu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2020, Volume and Issue: 12

Published: Nov. 4, 2020

The pathogenesis of Parkinson's disease (PD) remains elusive. Current thinking suggests that the activation microglia and subsequent release inflammatory factors, including interleukin-6 (IL-6), are involved in PD. P2X4 receptors (P2X4R) part P2X superfamily ion channels activated by ATP. To study possible effect ATP-P2X4R signal axis on IL-6 PD, lentivirus carrying P2X4R-overexpression gene or empty vector were injected into substantia nigra (SN) rats, followed treatment 6-hydroxydopamine (6-OHDA) saline one week later. research found relative expression P2X4R 6-OHDA-induced PD rat model was notably higher than those normal. And overexpression could upregulate IL-6, reduce amount dopaminergic (DA) neurons SN suggesting may mediate production to damage DA SN. Our data revealed important role modulating which leads neuroinflammation pathogenesis.

Language: Английский

Citations

17
Retinal Nerve Fiber Layer Thickness and Associations With Cognitive Impairment in Parkinson’s Disease DOI Creative Commons

Zihan Chang,

Fen Xie,

Hualing Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Feb. 10, 2022

This study intended to investigate whether retinal nerve fiber layer (RNFL) thickness could become a potential marker in patients with Parkinson's disease cognitive impairment (PD-CI). Fifty-seven PD and 45 age-matched healthy controls (HCs) were recruited our cross-sectional completed optical coherence tomography (OCT) evaluations. normal cognition (PD-NC) (PD-CI) divided following the 2015 Movement Disorder Society criteria. RNFL was quantified subfields of 3.0-mm circle surrounding optic disk; while battery neuropsychiatric assessments conducted estimate Parkinsonism severity. General linear models one-way ANOVA adopted assess between subgroups different statuses; logistic regression analyses applied determine relation PD-CI cases. Compared HCs, more thinning observed inferior temporal sectors patients, especially group. Inferior reduced compared PD-NC patients. Logistic analysis found that independently associated cases (odds ratio = 0.923, p 0.014). Receiver operating characteristic showed RNFL-involved combined model provided high accuracy screening deficiency (area under curve 0.85, < 0.001). Reduced sector is Our present new perspectives into verifying possible indicators for neuropathological processes or severity Parkinsonians dysfunction.

Language: Английский

Citations

10
QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis DOI Creative Commons
Hailing Liu, Zifeng Huang, Bin Deng

et al.

Aging and Disease, Journal Year: 2022, Volume and Issue: 14(1), P. 204 - 204

Published: Nov. 17, 2022

Parkinson's disease (PD) and atypical parkinsonism (AP), including progressive supranuclear palsy (PSP) multiple system atrophy (MSA), share similar nonmotor symptoms. Quantitative electroencephalography (QEEG) can be used to examine the This study aimed characterize patterns of QEEG functional connectivity (FC) that differentiate PD from PSP or MSA, explore correlation between differential indices dysfunctions in AP. We enrolled 52 patients with PD, 31 22 PSP, 50 age-matched health controls compare among specific brain regions. One-way analysis variance was applied assess groups; Spearman's correlations were relationship symptoms scale (NMSS) mini-mental state examination (MMSE). FCs using weighted phase lag index compared those MSA/PSP. Patients revealed higher scores on NMSS lower MMSE than duration. The delta theta powers a significant increase followed by MSA. presented significantly slow-to-fast ratio frontal region, while EEG-slowing showed negative positive perception mood domain but not PD. Compared MSA enhanced FC bands posterior decreased band within frontal-temporal cortex. These findings suggest might useful tool for evaluating Our results suggested duration, cortical neurodegenerative process likely exacerbated lastly

Language: Английский

Citations

10
Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review DOI Creative Commons
Zoë Thijs, Matthew Dumican

Laryngoscope Investigative Otolaryngology, Journal Year: 2023, Volume and Issue: 8(4), P. 970 - 979

Published: July 24, 2023

This study aimed to systematically review the associations between motor clinical phenotypes in Parkinson's disease (PD) and laryngeal symptoms. Laryngeal dysfunctions such as dysphonia dysphagia are ubiquitous people with (PwPD). Similar other symptoms, they manifest variably across PwPD. Some of variability within PD has been explained by phenotypes. However, it is unclear how symptoms express themselves these

Language: Английский

Citations

4
Multidisciplinary rehabilitation for Parkinson’s disease DOI
Hiroyuki Ohtsuka, N. Tashiro, Takeshi Hasegawa

et al.

Cochrane library, Journal Year: 2024, Volume and Issue: 2024(2)

Published: Feb. 2, 2024

Language: Английский

Citations

1