Transcranial electrical stimulation during functional magnetic resonance imaging in patients with genetic generalized epilepsy: a pilot and feasibility study DOI Creative Commons
Zachary D. Cohen, Mirja Steinbrenner, Rory J. Piper

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 19, 2024

Objective A third of patients with epilepsy continue to have seizures despite receiving adequate antiseizure medication. Transcranial direct current stimulation (tDCS) might be a viable adjunct treatment option, having been shown reduce epileptic in focal epilepsy. Evidence for the use tDCS genetic generalized (GGE) is scarce. We aimed establish feasibility applying during fMRI GGE study acute neuromodulatory effects tDCS, particularly on sensorimotor network activity. Methods Seven healthy controls and three received simultaneous acquisition while watching movie. Three conditions were applied: anodal, cathodal sham. Periods 60 s without applied between each condition. Changes cortex connectivity evaluated by calculating mean degree centrality across eight nodes defined Automated Anatomical Labeling atlas (primary motor (precentral left right), supplementary area (left mid-cingulum postcentral gyrus right)), conditions, participant. Results Simultaneous tDCS-fMRI was well tolerated both adverse effects. Anodal reduced (Friedman’s ANOVA Dunn’s multiple comparisons test; adjusted p = 0.02 0.03 respectively). Mean sham condition not different rest (adjusted 0.94). Conclusion Applying feasible safe small group GGE. caused significant reduction participants. This initial research supports using guide understand modulation that facilitate its clinical application future.

Language: Английский

Advances in the Treatment of Epilepsy by Electrostimulation of the Pulvinar DOI Creative Commons

Bingyang Shan,

Yang Dai, Quanlei Liu

et al.

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 20, 2025

Neuroregulatory therapy, encompassing deep brain stimulation and responsive neurostimulation, is increasingly gaining attention for the treatment of drug-resistant temporal occipital lobe epilepsy. Beyond approved anterior nucleus thalamus, pulvinar thalamus a potential target. Through confluence animal studies, electrophysiological research, imaging has been identified as having extensive connections with visual cortex, prefrontal limbic regions, multimodal sensory associative areas, playing pivotal role in multisensory integration serving propagation node both generalized focal This review synthesizes recent research on relation to cortical epileptic networks, well efficacy neuroregulatory therapy targeting Further warranted elucidate differential therapeutic effects stimulating various subregions specific mechanisms underlying epilepsy through stimulation.

Language: Английский

Citations

0
Long-Term Efficacy and Quality-of-Life Changes After Vagus Nerve Stimulation in Adult Patients With Drug-Resistant Epilepsy DOI Creative Commons

Edyta Zwolińska,

Marcin Birski, Szymon Hoppe

et al.

Journal of Clinical Neurology, Journal Year: 2025, Volume and Issue: 21(2), P. 113 - 113

Published: Jan. 1, 2025

There is a current need to understand the efficacy and quality of life (QoL) outcomes vagus nerve stimulation (VNS). Identifying patients most likely benefit from VNS could aid in their selection, reduce side effects, improve outcomes. Here we studied clinical QoL after with drug-resistant epilepsy attempted identify response predictors. This was retrospective study 55 treated surgically during 2004-2018, 40 whom were eligible for inclusion analysis. All surgeries performed using standard protocol by neurosurgeon experienced treatment referral an attending neurologist. Data collected medical records through 28-item questionnaire on seizure frequency, duration, strength before VNS, as number type postoperative complications significance patient, based 31-item Quality Life Epilepsy questionnaire. Improvements observed 65% VNS. The common complication hoarseness (70%), poorly tolerated 12% patients. Repeated surgery replace batteries or electrodes required 20% Health status only parameter significantly impacted No significant predictors identified. Efficacy across first month strong indicator long-term stimulator can be removed if it does not provide any benefit.

Language: Английский

Citations

0
Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential DOI

Mukul Shyam,

Oveyaa Bm,

Prathap Srirangan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 7, 2025

Language: Английский

Citations

0
Responsive neurostimulation for patients with mesial temporal lobe epilepsy: A systematic review and meta-analysis DOI Creative Commons
Eshita Sharma,

Beatriz Westphalen Pomianoski,

Rabbia Jabbar

et al.

Epilepsy & Behavior Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100774 - 100774

Published: April 1, 2025

Language: Английский

Citations

0
Safety and effectiveness of vagus nerve stimulation in patients with drug-resistant epilepsy: a single center experience DOI Creative Commons

Ebtehal O. Alwazna,

Jamal Abdullah,

Hanin Alsini

et al.

Acta Epileptologica, Journal Year: 2025, Volume and Issue: 7(1)

Published: May 9, 2025

Abstract Background Drug-resistant epilepsy (DRE) exerts substantial clinical, humanistic and economic burdens on patients, their families the healthcare system. Vagus nerve stimulation (VNS) has been extensively tested in clinical trial settings to decrease frequency of seizures patients with DRE who are not candidates for surgery; results indicate promising efficacy a well-tolerated safety profile. However, real-world evidence is still lacking. This retrospective study evaluated VNS DRE. Methods The current was chart review medical records children adults treated between December 2006 November 2022. primary outcome present percentage experienced reduction seizure more than 50% compared at baseline (the period before device insertion). Results A total 103 were included. achieved 23% six months, 36% 12 65% 18 72% 24 months. Similarly, complete resolution interictal epileptiform discharges (IEDs) increased from 30% months 60% after overall Quality Life Epilepsy (QOLIE-31) score end follow-up 39.46 ± 13.68 points. Two (1.9%) reported experiencing side effects follow-up. Conclusions implementation led significant IEDs, findings highlight potential role managing warrant its consideration treating

Language: Английский

Citations

0
Long-term outcome of vagus nerve stimulation therapy in drug-resistant epilepsy: a retrospective single-center study DOI Creative Commons
Si Chen,

Xiaxin Yang,

Shujun Xu

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Introduction Vagus nerve stimulation (VNS) has garnered widespread application in patients with drug-resistant epilepsy (DRE), while the efficacy and prognostic factors of VNS DRE remain elusive. Moreover, clinical determinants associated rapid response to have never been uncovered. This study aimed elucidate influencing VNS. Methods A consecutive series undergoing surgery from January 2014 December 2023 was collected describe efficacy. Both univariate multivariate analyses were performed identify statistically significant factors, a predictive model developed. Furthermore, we examined rapid/slow current changes. Results total 65 underwent implantation. Seizure frequency significantly decreased post-VNS, mean seizure reduction rates 35.7, 49.0, 48.5, 52.8, 63.2, 66.8% at 6 ( n = 65), 12 24 50), 36 40), 60 31), 84 19) months, respectively. At final follow-up, 61.5% (40/65) responders (50–100% reduction), 10.8% (7/65) achieved freedom for ≥1 year. Univariate analysis identified age onset ≥6 years p 0.003), baseline ≤30/month 0.001), focal seizures 0.002), developmental epileptic encephalopathies 0.037), surgical history < 0.001) as factors. Multivariate confirmed (OR: 5.726, 0.039), 4.697, 0.048), 4.791, 0.025) independent predictors, enabling development Additionally, among responders, median duration months (range: 1–60 months), (<6 0.033). Conclusion is effective treating DRE, increasing follow-up duration. Age years, ≤30/month, success, underscoring need careful preoperative assessment before surgery.

Language: Английский

Citations

0
Effect of vagus nerve stimulation against generalized seizure and status epilepticus recurrence DOI Creative Commons
Yasushi Iimura, Hiroharu Suzuki, Takumi Mitsuhashi

et al.

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 15, 2023

Objective Vagus nerve stimulation (VNS) is a palliative surgery for drug-resistant epilepsy. The two objectives of this study were to (1) determine the seizure type most responsive VNS and (2) investigate preventive effect on status epilepticus (SE) recurrence. Methods We retrospectively reviewed 136 patients with epilepsy who underwent implantation. examined outcomes at 6, 12, 24 months following implantation as well last visit Juntendo Epilepsy Center. Univariate analysis multivariate logistic regression models used estimate prognostic factors. Results 125 followed up least 1 year after percentage 50% reduction in frequency compared prior increased over time implantation: 28, 41, 52%, respectively. Regarding overall outcomes, 70 (56%) responded VNS. Of 40 history SE implantation, 27 (67%) showed no recurrence SE. duration epilepsy, correlated univariate ( p = 0.05, < 0.01, 0.03, respectively). In analysis, generalized was associated response [odds ratio (OR): 4.18, 95% CI: 1.13–15.5, 0.03]. A non-responders [(OR): 0.221, 0.097–0.503, 0.01]. focal bilateral tonic–clonic epileptic spasms not significantly responders 0.07, 0.71, 0.11, Conclusion Following an average 69 months, 56% This suggests that VNS, may reduce risk shown be effective against also potentially influence further events SE, marker disease treatment can lead improved quality life.

Language: Английский

Citations

9
Deep Brain Stimulation for Children with Generalized Epilepsy DOI
Rory J. Piper, George M. Ibrahim, Martin Tisdall

et al.

Neurosurgery Clinics of North America, Journal Year: 2023, Volume and Issue: 35(1), P. 17 - 25

Published: Sept. 27, 2023

Language: Английский

Citations

8
Attenuation of Strychnine-Induced Epilepsy Employing Amaranthus viridis L. Leaves Extract in Experimental Rats DOI Creative Commons

Aashish Bharadwaj,

Ashwani Sharma, Talever Singh

et al.

Behavioural Neurology, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 10

Published: March 14, 2023

Epilepsy is one of the most prevalent neurological illnesses defined by periodic seizures with or without loss consciousness caused aberrant neural activity. There are many allopathic medications available for treatment epilepsy such as phenytoin (PHY), but side effects a major concern. Therefore, present study involved evaluation pharmacological significance Amaranthus viridis L. extract (EAV) in management strychnine (STR)-induced epilepsy.STR (3.5 mg/kg, i.p.) was injected into male rats 30 minutes after pre-treatment standard drug (PHY: 20 mg/kg) and two doses EAV (EAV-200 EAV-400 p.o.) to respective groups cause convulsions. The anti-convulsant effect EAV-200 against STR-induced convulsion investigated terms onset, duration convulsions, number score. Furthermore, mitochondrial function integrity brain's prefrontal cortex (PFC) were also estimated.EAV-400 significantly increased onset from 61.67 ± 3.051 119.2 2.738 reduced convulsions 144.8 3.582 69.17 3.736, 4.000 0.1592 1.533 0.1542, score 5.000 0.3651 2.833 0.3073 rats. attenuated decrease rat PFC. In rats, accelerated while decreasing duration, frequency, score.Based on investigational findings, could be inferred possible anti-epileptic option this plan preclinical research.

Language: Английский

Citations

7
The landscape of drug resistant absence seizures in adolescents and adults: Pathophysiology, electroclinical spectrum and treatment options DOI

Géraldine Daquin,

Francesca Bonini

Revue Neurologique, Journal Year: 2024, Volume and Issue: 180(4), P. 256 - 270

Published: Feb. 26, 2024

Language: Английский

Citations

2