Multiple stressors in the Anthropocene: Urban evolutionary history modifies sensitivity to the toxic effects of crude oil exposure in killifish
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Persistence
of
wild
species
in
human-altered
environments
is
difficult,
part
because
challenges
to
fitness
are
complex
when
multiple
environmental
changes
occur
simultaneously,
which
common
the
Anthropocene.
This
complexity
difficult
conceptualize
nature
change
often
highly
context
specific.
A
mechanism-guided
approach
may
help
shape
intuition
and
predictions
about
complexity;
posed
by
co-occurring
stressors
with
similar
mechanisms
action
be
less
severe
than
for
those
different
action.
We
these
considerations
within
ecotoxicology
this
field
built
upon
a
rich
mechanistic
foundation.
hypothesized
that
evolved
resistance
one
class
toxicants
would
afford
resilience
impacts
another
shares
toxicity.
Fundulus
killifish
populations
urban
estuaries
have
repeatedly
persistent
organic
pollutants
including
PCBs.
Since
PCBs
some
constitute
crude
oil
(e.g.,
high
molecular
weight
PAHs)
exert
toxicity
through
perturbation
AHR
signaling,
we
predicted
PCB
resistant
also
resilient
Common
garden
comparative
exposure
experiments,
histories,
showed
most
were
sensitive
(reproduction
development)
caused
exposure,
but
fish
from
PCB-resistant
population
insensitive.
Population
differences
toxic
outcomes
not
compatible
random-neutral
expectations.
Transcriptomics
revealed
contributed
variation
PAH
shared
contribute
resilience.
conclude
challenge
effectively
reduced
chemicals
share
affect
fitness.
Mechanistic
scale
regarding
co-occur
environments.
Language: Английский
The Genome of Lolium multiflorum Reveals the Genetic Architecture of Paraquat Resistance
Molecular Ecology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
ABSTRACT
Herbicide
resistance
in
agricultural
weeds
has
become
one
of
the
greatest
challenges
for
sustainable
crop
production.
The
repeated
evolution
herbicide
provides
an
excellent
opportunity
to
study
genetic
and
physiological
basis
phenotype
evolutionary
responses
human‐mediated
selection
pressures.
Lolium
multiflorum
is
a
ubiquitous
weed
that
evolved
repeatedly
around
world
various
cropping
systems.
We
assembled
annotated
chromosome‐scale
genome
L.
elucidated
architecture
paraquat
by
performing
quantitative
trait
locus
analysis,
genome‐wide
association
studies,
divergence
analysis
transcriptome
analyses
from
paraquat‐resistant
‐susceptible
plants.
identified
two
regions
on
chromosome
5
were
associated
with
resistance.
These
both
showed
evidence
positive
among
resistant
populations
we
sampled,
but
effects
this
differed,
implying
complex
history.
In
addition,
these
contained
candidate
genes
encoded
cellular
transport
functions,
including
novel
multidrug
toxin
extrusion
(MATE)
protein
cation
transporter
previously
shown
interact
polyamines.
Given
cultivated
species,
genomic
resources
generated
will
prove
valuable
wide
spectrum
plant
science
community.
Our
work
contributes
growing
body
knowledge
underlying
ecological
dynamics
rapid
adaptation
strong
anthropogenic
pressure
could
help
initiate
efforts
improve
management
practices
long
term
more
agriculture.
Language: Английский
Transcriptomic and Methylomic Analyses Show Significant Shifts in Biosynthetic Processes and Reduced Intrapopulation Gene Expression Variance in PAH-Adapted Atlantic Killifish
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 17, 2024
Environmental
contaminants
pose
a
significant
selection
pressure
across
taxa,
potentiating
evolved
resistance
to
chemicals.
However,
rapid
evolution
may
alter
molecular
and
physiological
homeostasis
leading
trade-offs.
To
elucidate
underpinnings
of
chemical
resistance,
we
compared
liver
gene
expression
methylation
profiles
in
polycyclic
aromatic
hydrocarbon
(PAH)-adapted
Atlantic
killifish
(
Language: Английский