Frontiers in Molecular Biosciences,
Journal Year:
2023,
Volume and Issue:
10
Published: Sept. 6, 2023
Cancer
of
the
corpus
uteri
and
cervix
uteri,
collectively
ranks
second
among
new
cancer
cases
in
women
after
breast
cancer.
Therefore,
investigation
anticancer
agents
identifying
molecular
targets
presents
a
challenge
to
improve
effectiveness
chemotherapy.
In
this
study,
antiproliferative
activity
flavonoids
derived
from
buds
silver
birch
downy
was
evaluated
endometrial
Ishikawa
cells
cervical
HeLa
cells.
It
found
that
flavanol
santin
reduced
viability
both
cell
lines
better
than
other
flavonoids,
including
apigenin
luteolin.
Moreover,
slightly
higher
induced
by
chemotherapy
drug,
cisplatin.
Santin
promoted
intrinsic
extrinsic
apoptosis
pathways
cells,
but
it
had
low
toxicity
normal
fibroblasts.
The
mechanisms
impairing
included
induction
oxidative
proline
catabolism,
however
different
ways
used.
increase
oxidation
due
activation
p53
leading
oxidase
upregulation.
contrast,
having
basal
level
significantly
treatment
decreased
its
expression.
Nevertheless,
these
since
increased
expression
prolidase,
an
enzyme
providing
protein
degradation.
lines,
associated
with
generation
reactive
oxygen
species
reduction
viability.
Our
findings
reveal
involvement
identify
role
prolidase
oxidase-dependent
apoptosis.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 29, 2024
Amino
acid
metabolism
plays
a
pivotal
role
in
tumor
microenvironment,
influencing
various
aspects
of
cancer
progression.
The
metabolic
reprogramming
amino
acids
cells
is
intricately
linked
to
protein
synthesis,
nucleotide
modulation
signaling
pathways,
regulation
cell
metabolism,
maintenance
oxidative
stress
homeostasis,
and
epigenetic
modifications.
Furthermore,
the
dysregulation
also
impacts
microenvironment
immunity.
can
act
as
molecules
that
modulate
immune
function
tolerance
within
reshaping
anti-tumor
response
promoting
evasion
by
cells.
Moreover,
influence
behavior
stromal
cells,
such
cancer-associated
fibroblasts,
regulate
ECM
remodeling
promote
angiogenesis,
thereby
facilitating
growth
metastasis.
Understanding
intricate
interplay
between
crucial
significance.
Expanding
our
knowledge
multifaceted
roles
holds
significant
promise
for
development
more
effective
therapies
aimed
at
disrupting
dependencies
modulating
enhance
responses
inhibit
Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
31(1)
Published: Jan. 6, 2025
Several
members
of
the
NIMA-related
kinase
(NEK)
family
have
been
implicated
in
tumor
progression;
however,
role
and
underlying
mechanisms
NEK8
gastric
cancer
(GC)
remain
unclear.
This
study
revealed
a
significant
upregulation
GC,
identifying
it
as
an
independent
prognostic
marker
patients
with
GC.
Consistent
these
findings,
silencing
substantially
impeded
GC
aggressiveness
both
vitro
vivo,
while
its
overexpression
produced
opposite
effect.
Gene
Ontology
enrichment
analysis
metabolic
profiling
indicated
that
impact
on
is
primarily
associated
reprogramming
asparagine
metabolism
modulating
mTORC1
pathway.
Specifically,
knockdown
suppressed
synthesis
by
downregulating
synthetase
(ASNS)
expression
cells.
A
strong
correlation
was
observed
between
levels
ASNS
human
cells
tissue
samples.
Mechanistically,
directly
interacts
ASNS,
phosphorylating
at
S349
site,
which
inhibits
ubiquitination
subsequent
degradation.
Moreover,
substituting
ASNS-S349
site
alanine
abrogated
pro-tumorigenic
effects
ASNS-WT
overexpression.
Additionally,
identified
activator
pathway,
reintroducing
after
restoring
activity.
Collectively,
findings
demonstrate
NEK8-mediated
activation
pathway
play
critical
promoting
progression.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 19, 2024
Metabolic
changes
precede
malignant
histology.
However,
it
remains
unclear
whether
detectable
characteristic
metabolome
exists
in
esophageal
squamous
cell
carcinoma
(ESCC)
tissues
and
biofluids
for
early
diagnosis.
Here,
we
conduct
NMR-
MS-based
metabolomics
on
1,153
matched
ESCC
tissues,
normal
mucosae,
pre-
one-week
post-operative
sera
urines
from
560
participants
across
three
hospitals,
with
machine
learning
WGCNA.
Aberrations
'alanine,
aspartate
glutamate
metabolism'
proved
to
be
prevalent
throughout
the
evolution,
consistently
identified
by
NMR
MS,
reflected
16
serum
10
urine
metabolic
signatures
both
discovery
validation
sets.
NMR-based
simplified
panels
of
any
five
or
metabolites
outperform
clinical
serological
tumor
markers
(AUC
=
0.984
0.930,
respectively),
are
effective
distinguishing
early-stage
test
set
(serum
accuracy
0.994,
0.879).
Collectively,
biofluid
screening
can
reveal
events
feasible
detection
(ChiCTR2300073613).
Oncogene,
Journal Year:
2024,
Volume and Issue:
43(23), P. 1727 - 1741
Published: May 8, 2024
Abstract
Epigenetic
regulation
established
during
development
to
maintain
patterns
of
transcriptional
expression
and
silencing
for
metabolism
other
fundamental
cell
processes
can
be
reprogrammed
in
cancer,
providing
a
molecular
mechanism
persistent
alterations
phenotype.
Metabolic
deregulation
reprogramming
are
thus
an
emerging
hallmark
cancer
with
opportunities
classification
as
critical
preliminary
step
precision
therapeutic
intervention.
Yet,
acquisition
therapy
resistance
against
most
conventional
treatment
regimens
coupled
tumor
relapse,
continue
pose
unsolved
problems
healthcare,
exemplified
breast
where
existing
data
informs
both
genotype
Furthermore,
epigenetic
reprograming
the
metabolic
milieu
cells
is
among
crucial
determinants
relapse.
Importantly,
subtype-specific
epigenetic-metabolic
interplay
profoundly
affects
malignant
transformation,
chemotherapy,
response
targeted
therapies.
In
this
review,
we
therefore
prismatically
dissect
interconnected
regulatory
pathways
then
integrate
them
into
observable
metabolism-therapy-resistance
axis
that
may
inform
clinical
Optimally
coupling
genome-wide
analysis
understanding
elements,
reprogramming,
their
integration
by
profiling
decode
missing
mechanisms
at
level
individual
tumors.
The
proposed
approach
linking
biochemistry
back
genotype,
epigenetics,
phenotype
specific
tumors
microenvironment
enable
successful
mechanistic
targeting
modifiers
oncometabolites
despite
heterogeneity.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 347 - 347
Published: Jan. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Journal of Enzyme Inhibition and Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
39(1)
Published: July 25, 2024
Metabolic
abnormalities
are
an
important
feature
of
tumours.
The
glutamine-arginine-proline
axis
is
node
cancer
metabolism
and
plays
a
major
role
in
amino
acid
metabolism.
This
also
acts
as
scaffold
for
the
synthesis
other
nonessential
acids
essential
metabolites.
In
this
paper,
we
briefly
review
(1)
glutamine
addiction
exhibited
by
tumour
cells
with
accelerated
transport
metabolism;
(2)
methods
regulating
extracellular
entry,
intracellular
fate
glutamine;
(3)
glutamine,
proline
arginine
metabolic
pathways
their
interaction;
(4)
research
progress
therapy
targeting
system,
focus
on
summarising
therapeutic
strategies
one
key
enzymes
P5CS
(ALDH18A1).
provides
new
basis
treatments
characteristics
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116452 - 116452
Published: March 18, 2024
Autoimmune
hepatitis
(AIH)
is
an
inflammatory
chronic
liver
disease
with
persistent
and
recurrent
immune-mediated
injury.
The
exact
cause
of
AIH
still
not
fully
understood,
but
it
believed
to
be
primarily
due
abnormal
activation
the
immune
system,
leading
autoimmune
injury
caused
by
breakdown
tolerance.
Although
pathogenesis
remains
unclear,
recent
studies
have
shown
that
abnormalities
in
amino
acid
metabolism
play
significant
roles
its
development.
These
can
lead
remodeling
metabolic
processes,
signaling
pathways,
responses,
which
may
present
new
opportunities
for
clinical
intervention
AIH.
In
this
paper,
we
first
briefly
outline
progress
clinically
relevant
research
on
AIH,
focusing
role
specific
(including
glutamine,
cysteine,
tryptophan,
branched-chain
acids,
etc.)
their
associated
metabolites,
as
well
related
development
Furthermore,
discuss
scientific
issues
remain
resolved
regarding
metabolism,
interventions,
aim
contributing
future
metabolism-based
a
target
diagnosis
treatment
