Fibrinogen Oxidation and Thrombosis: Shaping Structure and Function

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 390 - 390

Published: March 26, 2025

Fibrinogen, a pivotal plasma glycoprotein, plays an essential role in hemostasis by serving as the precursor to fibrin, which forms structural framework of blood clots. Beyond coagulation, fibrinogen influences immune responses, inflammation, and tissue repair. Oxidative stress, characterized imbalance between reactive oxygen species (ROS) antioxidants, induces oxidation, significantly altering its structure function. This narrative review synthesizes findings from vitro, ex vivo, clinical studies, emphasizing impact oxidation on clot formation, architecture, degradation. modifications result denser fibrin clots with thinner fibers, reduced permeability, heightened resistance fibrinolysis. These changes exacerbate prothrombotic conditions cardiovascular diseases, diabetes, chronic inflammatory disorders cancer. In contrast, “low-dose” oxidative stress may elicit protective adaptations fibrinogen, preserving The also highlights discrepancies experimental due variability protocols patient conditions. Understanding interplay function could unveil therapeutic strategies targeting stress. Antioxidant therapies or selective inhibitors detrimental hold potential for mitigating thrombotic risks. However, further research is pinpoint specific sites, clarify their roles dynamics, bridge gap basic practice.

Language: Английский

Fibrinogen Structural Changes and Their Potential Role in Endometriosis-Related Thrombosis

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1456 - 1456

Published: Nov. 27, 2024

Endometriosis (EM), a chronic inflammatory condition predominantly affecting women of reproductive age, has been linked to an elevated risk thrombosis, though its underlying molecular mechanisms remain incompletely understood. In this case-control study, involving 71 EM patients and matched controls, we explored the structural functional changes in fibrinogen their potential role thrombosis. Key oxidative stress markers, such as reactive oxygen species (ROS) levels blood lymphocytes, monocytes, granulocytes, along with plasma lipid peroxidation markers total antioxidant capacity, were measured. Fibrinogen structure was examined using circular dichroism spectroscopy intrinsic fluorescence, while properties evaluated by analyzing thrombin-mediated polymerization plasmin-induced lysis. Compared exhibited ROS production systemic stress, leading notable oxidation alterations. These associated impaired fibrin enhanced resistance lysis, which are indicative pro-thrombotic state. findings suggest that stress-driven modifications may contribute heightened thrombotic EM, highlighting therapeutic target mitigate cardiovascular complications.

Language: Английский