Gut microbiota: our fellow travellers in health & disease DOI Open Access
John F. Cryan

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The last two decades have seen a major increase in our understanding of the role microbiome health and disease. We now realise that these fellow travellers are really important regulators various systems body across lifespan. In this Special Issue, we bring together collection articles from leading authors who summarise current state art host-microbe interactions. While celebrate breakthroughs science, also acknowledge challenges-variability microbiota composition, complexities interactions need for standardised methodologies. As research progresses, harnessing power may pave way novel diagnostic therapeutic strategies, reaffirming notion never alone-our microbial accompany us through life, better or worse.

Language: Английский

Bifidobacteria support optimal infant vaccine responses DOI Creative Commons
Feargal J. Ryan, Michelle Clarke, Miriam A. Lynn

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Accumulating evidence indicates that antibiotic exposure may lead to impaired vaccine responses1-4; however, the mechanisms underlying this association remain poorly understood. Here we prospectively followed 191 healthy, vaginally born, term infants from birth 15 months, using a systems vaccinology approach assess effects of on immune responses vaccination. Exposure direct neonatal but not intrapartum antibiotics was associated with significantly lower antibody titres against various polysaccharides in 13-valent pneumococcal conjugate and Haemophilus influenzae type b polyribosylribitol phosphate diphtheria toxoid antigens combined 6-in-1 Infanrix Hexa at 7 months age. Blood exposed had an inflammatory transcriptional profile before vaccination; addition, faecal metagenomics showed reduced abundance Bifidobacterium species these time vaccination, which correlated 6 later. In preclinical models, were strongly dependent intact microbiota could be restored germ-free mice by administering consortium or probiotic already widely used units. Our data suggest microbiota-targeted interventions mitigate detrimental early-life immunogenicity.

Language: Английский

Citations

1
Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine DOI

Yupeng Feng,

De Jong,

Ana Paula B N Oliveira

et al.

Cell Host & Microbe, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Gut microbiota: our fellow travellers in health & disease DOI Open Access
John F. Cryan

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

The last two decades have seen a major increase in our understanding of the role microbiome health and disease. We now realise that these fellow travellers are really important regulators various systems body across lifespan. In this Special Issue, we bring together collection articles from leading authors who summarise current state art host-microbe interactions. While celebrate breakthroughs science, also acknowledge challenges-variability microbiota composition, complexities interactions need for standardised methodologies. As research progresses, harnessing power may pave way novel diagnostic therapeutic strategies, reaffirming notion never alone-our microbial accompany us through life, better or worse.

Language: Английский

Citations

0