Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress DOI Creative Commons
Millie Rincón‐Cortés

Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 6, P. 100067 - 100067

Published: Jan. 26, 2023

In humans, exposure to early life stress (ELS) is an established risk factor for the development of substance use disorders (SUDs) during later life. Similarly, rodents exposed ELS involving disrupted mother-infant interactions, such as maternal separation (MS) or adverse caregiving due scarcity-adversity induced by limited bedding and nesting (LBN) conditions, also exhibit long-term alterations in alcohol drug consumption. both humans rodents, there a range addiction-related behaviors that are associated with even predictive subsequent SUDs. these include increased anxiety-like behavior, impulsivity, novelty-seeking, altered intake patterns, well reward-related processes consummatory social behaviors. Importantly, expression often varies throughout lifespan. Moreover, preclinical studies suggest sex differences play role how impacts reward phenotypes underlying brain circuitry. Here, addiction-relevant behavioral outcomes mesolimbic dopamine (DA) dysfunction resulting from form MS LBN discussed focus on age- sex-dependent effects. Overall, findings may increase susceptibility SUDs interfering normal maturation function.

Language: Английский

Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review DOI Creative Commons
Anna Zilverstand, Anna Huang, Nelly Alia‐Klein

et al.

Neuron, Journal Year: 2018, Volume and Issue: 98(5), P. 886 - 903

Published: June 1, 2018

Language: Английский

Citations

440
The transition to compulsion in addiction DOI
Christian Lüscher, Trevor W. Robbins, Barry J. Everitt

et al.

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 247 - 263

Published: March 30, 2020

Language: Английский

Citations

383
Rigor and reproducibility in rodent behavioral research DOI
Maria Gulinello, Heather A. Mitchell, Qiang Chang

et al.

Neurobiology of Learning and Memory, Journal Year: 2018, Volume and Issue: 165, P. 106780 - 106780

Published: Jan. 4, 2018

Language: Английский

Citations

95
DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence DOI Creative Commons
Charlotte A. M. Cecil, Esther Walton, Rebecca G. Smith

et al.

Translational Psychiatry, Journal Year: 2016, Volume and Issue: 6(12), P. e976 - e976

Published: Dec. 6, 2016

Abstract Epigenetic processes have been implicated in addiction; yet, it remains unclear whether these represent a risk factor and/or consequence of substance use. Here, we believe conducted the first genome-wide, longitudinal study to investigate DNA methylation patterns early life prospectively associate with use adolescence. The sample comprised 244 youth (51% female) from Avon Longitudinal Study Parents and Children (ALSPAC), repeated assessments (Illumina 450k array; cord blood at birth, whole age 7) (tobacco, alcohol cannabis use; 14–18). We found that, epigenetic variation across tightly interconnected genetic network ( n =65 loci; q <0.05) associated greater levels during adolescence, as well an earlier onset amongst users. Associations were specific neonatal period not observed 7. Key annotated genes included PACSIN1, NEUROD4 NTRK2 , neurodevelopmental processes. Several identified loci known quantitative trait loci, consequently likely be under significant control. Collectively, 65 also partially mediate effect prenatal maternal tobacco smoking on adolescent Together, findings lend novel insights into correlates use, highlight birth potentially sensitive window biological vulnerability provide preliminary evidence indirect pathway linking exposure

Language: Английский

Citations

92
Brain-wide functional architecture remodeling by alcohol dependence and abstinence DOI Open Access
Adam Kimbrough, Daniel J. Lurie, Andrés Collazo

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(4), P. 2149 - 2159

Published: Jan. 14, 2020

Significance Visualizing functional changes in brain networks that are produced by alcohol use and dependence is a critical step our understanding of the consequences drinking alcohol. Because technical limitations, visualizing throughout whole at single-cell resolution has not been possible. The present study used whole-brain imaging approach mice to assess whether abstinence alters architecture brain. Compared with nondrinkers casual drinkers, alcohol-dependent exhibited widespread increases coordinated activity during decrease modularity. We also identified target regions for future research provide atlas may be better understand use, dependence, abstinence.

Language: Английский

Citations

89
Impulsivities and addictions: a multidimensional integrative framework informing assessment and interventions for substance use disorders DOI Creative Commons
Jasmin Vassileva, Patricia Conrod

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2018, Volume and Issue: 374(1766), P. 20180137 - 20180137

Published: Dec. 31, 2018

Impulse control is becoming a critical survival skill for the twenty-first century. Impulsivity implicated in virtually all externalizing behaviours and disorders, figures prominently aetiology long-term sequelae of substance use disorders (SUDs). Despite its robust clinical predictive validity, study impulsivity complicated by multidimensional nature, characterized variety trait-like personality dimensions, as well more state-dependent neurocognitive with variable convergence across measures. This review provides hierarchical framework linking self-report measures to latent constructs and, turn, different psychopathology vulnerabilities, including substance-specific addictions comorbidities. dimensions are presented novel behavioural targets prevention intervention. Novel treatment approaches addressing domains reviewed recommendations future directions research interventions SUDs offered. article part theme issue ‘Risk taking impulsive behaviour: fundamental discoveries, theoretical perspectives implications’.

Language: Английский

Citations

87
Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms DOI
Mitchell R. Farrell, Hannah Schoch, Stephen V. Mahler

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2018, Volume and Issue: 87, P. 33 - 47

Published: Jan. 3, 2018

Language: Английский

Citations

86
Mapping sign-tracking and goal-tracking onto human behaviors DOI
Janna M. Colaizzi, Shelly B. Flagel,

Michelle A. Joyner

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 111, P. 84 - 94

Published: Jan. 20, 2020

Language: Английский

Citations

85
Androgen Misuse and Abuse DOI Open Access
David J. Handelsman

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 42(4), P. 457 - 501

Published: Jan. 23, 2021

Abstract Androgens are potent drugs requiring prescription for valid medical indications but misused invalid, unproven, or off-label reasons as well being abused without illicit nonmedical application performance image enhancement. Following discovery and first clinical of testosterone in the 1930s, commercialization synthetic androgens proliferated decades after World War II. It remains among oldest marketed therapeutic use, yet 8 sole unequivocal indication replacement therapy pathological hypogonadism, organic disorders male reproductive system. Nevertheless, wider claims assert unsafe, implausible benefits testosterone, mostly representing wishful thinking about rejuvenation. Over recent decades, this created an epidemic misuse involving a revitalizing tonic anti-aging, sexual dysfunction and/or obesity, where efficacy safety unproven doubtful. Androgen abuse originated during Cold androgen doping elite athletes enhancement before 1980s when it crossed over into general community to become endemic variant drug sufficiently affluent communities that support industry geared bodybuilding aiming create hypermasculine body physique image. This review focuses on defined prescribing indications, (androgen abuse), use typically by athletes, bodybuilders others image-oriented, cosmetic, occupational reasons.

Language: Английский

Citations

64
Consolidating the Circuit Model for Addiction DOI
Christian Lüscher, Patricia H. Janak

Annual Review of Neuroscience, Journal Year: 2021, Volume and Issue: 44(1), P. 173 - 195

Published: March 5, 2021

Addiction is a disease characterized by compulsive drug seeking and consumption observed in 20–30% of users. An addicted individual will favor reward over natural rewards, despite major negative consequences. Mechanistic research on rodents modeling core components the has identified altered synaptic transmission as functional substrate pathological behavior. While initial version circuit model for addiction focused early adaptive behaviors all individuals, it fell short accounting stochastic nature transition to compulsion. The builds pharmacological effect common addictive drugs—an increase dopamine levels mesolimbic system. Here, we consolidate this integrating circuits underlying compulsion reinforcement. We discuss genetic epigenetic correlates vulnerability. Many recent data converge gain-of-function explanation remodeling, revealing blueprints novel therapies.

Language: Английский

Citations

62