Emerging Strategies to Protect the Skin from Ultraviolet Rays Using Plant-Derived Materials

Antioxidants, Journal Year: 2020, Volume and Issue: 9(7), P. 637 - 637

Published: July 18, 2020

Sunlight contains a significant amount of ultraviolet (UV) ray, which leads to various effects on homeostasis in the body. Defense strategies protect from UV rays have been extensively studied, as sunburn, photoaging, and photocarcinogenesis are caused by excessive exposure. The primary lines defense against damage melanin trans-urocanic acid, distributed stratum corneum. that pass beyond these can lead oxidative damage. However, cells detect changes due early possible initiate cell signaling processes prevent occurrence repair already occurred Cosmetic dermatology experts recommend using sunscreen product UV-induced A variety antioxidants anti-inflammatory agents also developed complement skin’s defenses rays. Researchers examined use plant-derived materials alleviate skin aging, diseases, cancer Furthermore, studies underway determine how promote production This review provides discussion occurs light describes potential materials. aims assist researchers understanding current research this area potentially plan future studies.

Language: Английский

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Effects of Air Pollution on Cellular Senescence and Skin Aging

Cells, Journal Year: 2022, Volume and Issue: 11(14), P. 2220 - 2220

Published: July 17, 2022

The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution considered a harmful risk known promote aging inflammation of this tissue, leading the onset disorders appearance wrinkles pigmentation issues. Besides this, components can interact synergistically with light increase impact damage skin. However, little about modulation on cellular senescence in cells how contribute aging. In review, we are summarizing current state knowledge components, their involvement processes aging, well therapeutic cosmetic interventions proposed prevent or mitigate effects

Language: Английский

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The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 307 - 307

Published: Jan. 27, 2022

In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, fibroblasts. The treatment with colostrum prevented generation intracellular reactive oxygen species epidermal keratinocytes. UV-stimulated could also significantly reduce production protective skin-darkening pigment melanin, which may help to risk excessive melanin formation causing hyperpigmentation disorders. human dermal fibroblasts treated exosomes, expression matrix metalloproteinases was suppressed, whereas increased cell proliferation accompanied by enhanced collagen, a extracellular component skin. Taken together, our findings indicate that having excellent structural functional stability offer great potential as natural therapeutic agents repair UV-irradiated damage.

Language: Английский

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Medicinal Plant Extracts Targeting UV-Induced Skin Damage: Molecular Mechanisms and Therapeutic Potential

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2278 - 2278

Published: March 4, 2025

The depletion of the ozone layer has intensified ultraviolet (UV) radiation exposure, leading to oxidative stress, DNA damage, inflammation, photoaging, and skin cancer. Medicinal plants, widely used in Traditional Herbal Medicine (THM), particularly Chinese (TCM), have demonstrated significant therapeutic potential due their well-characterized active compounds established photoprotective effects. This review systematically evaluates 18 medicinal plants selected based on traditional use skin-related conditions emerging evidence supporting efficacy against UV-induced damage. Their bioactive components exert antioxidant, anti-inflammatory, repair, depigmentation effects by modulating key signaling pathways, including Nrf2/ARE-, MAPK/AP-1-, PI3K/Akt-, MITF/TYR-related melanogenesis pathways. Moreover, novel drug delivery systems, such as exosomes, hydrogels, nanoemulsions, significantly enhanced stability, bioavailability, penetration these compounds. However, challenges remain standardizing plant-derived formulations, elucidating complex synergistic mechanisms, translating preclinical findings into clinical applications. Future interdisciplinary research technological advancements will be essential harness full for damage prevention treatment.

Language: Английский

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Metabolism and Functions of Amino Acids in the Skin

Advances in experimental medicine and biology, Journal Year: 2020, Volume and Issue: unknown, P. 187 - 199

Published: Jan. 1, 2020

Language: Английский

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Resveratrol as a Multifunctional Topical Hypopigmenting Agent

International Journal of Molecular Sciences, Journal Year: 2019, Volume and Issue: 20(4), P. 956 - 956

Published: Feb. 22, 2019

Melanin is produced in melanocytes and stored melanosomes, after which it transferred to keratinocytes and, thus, determines skin color. Despite its beneficial sun-protective effects, abnormal accumulation of melanin results esthetic problems. A range topical hypopigmenting agents have been evaluated for their use the treatment pigmentary disorders with varying degrees success. Hydroquinone (HQ), competes tyrosine, main ingredient pharmacological agents. However, frequent occurrence adverse reactions an important factor that limits use. Thus, efforts discover effective less effects continue. Here, we describe potential resveratrol function as agent based on mechanism action. Resveratrol not only a direct tyrosinase inhibitor but indirect well. Additionally, can affect keratinocytes, regulate melanocytes. regulates inflammatory process protects them from oxidative damage. In this way, prevents keratinocyte-induced melanocyte stimulation. Furthermore, has rescuing effect stemness interfollicular epidermal cells repair signs photoaging melasma, typical disorder. Overall, promising potent agent.

Language: Английский

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Alterations of the pigmentation system in the aging process

Pigment Cell & Melanoma Research, Journal Year: 2021, Volume and Issue: 34(4), P. 800 - 813

Published: May 28, 2021

Human skin aging is a natural phenomenon that results from continuous exposure to intrinsic (time, genetic factors, hormones) as well extrinsic factors (UV exposure, pollution, tobacco). In areas are frequently exposed the sun, photoaging blends with process of aging, resulting in an increased senescent cells number and consequently accelerating process. The severity photodamage depends on constitutional including phototype (skin color, tanning capacity), intensity, duration sunlight/UV exposure. Aging affects nearly every aspect cutaneous biology, pigmentation. Clinically, phenotype age pigmented has mottled, uneven primarily due spots, or without hypopigmentation. Uneven pigmentation might be attributed hyperactivation melanocytes, altered distribution pigment, turnover. addition direct damage pigment-producing cells, alters physiological crosstalk between keratinocytes, fibroblasts, endothelial melanocytes responsible for homeostasis. Interestingly, age-independent diffuse expression senescence-associated markers dermal epidermal compartment also associated vitiligo, suggesting premature senescence plays important role pathology.

Language: Английский

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microRNAs in the Regulation of Melanogenesis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 6104 - 6104

Published: June 5, 2021

Melanogenesis is the process leading to synthesis of melanin, main substance that influences skin color and plays a pivotal role against UV damage. Altered melanogenesis observed in several pigmentation disorders. occurs specialized cells called melanocytes, physically functionally related by means autocrine paracrine interplay other cell types. Several external internal factors control melanin biosynthesis operate through different intracellular signaling pathways, which finally leads regulation microphthalmia-associated transcription factor (MITF), key involved expression melanogenic enzymes, including TYR, TYRP-1, TYRP-2. Epigenetic factors, microRNAs (miRNAs), are regulation. miRNAs small, single-stranded, non-coding RNAs, approximately 22 nucleotides length, behavior regulating gene expression, mainly binding 3' untranslated region (3'-UTR) target mRNAs. This review collects data on how these can modulate expression. Bringing light biological function could lead wider understanding epigenetic its dysregulation. knowledge may constitute basis for developing innovative treatment approaches

Language: Английский

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A supergene underlies linked variation in color and morphology in a Holarctic songbird

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 25, 2021

Abstract The genetic architecture of a phenotype can have considerable effects on the evolution trait or species. Characterizing provides insight into complexity given and, potentially, role in evolutionary processes like speciation. We use genome sequences to investigate basis phenotypic variation redpoll finches ( Acanthis spp.). demonstrate that is broadly controlled by ~55-Mb chromosomal inversion. Within this inversion, we find multiple candidate genes related melanogenesis, carotenoid coloration, and bill shape, suggesting inversion acts as supergene controlling linked traits. A latitudinal gradient ecotype distribution suggests driven color morphology are likely under environmental selection, maintaining haplotypes balanced polymorphism. Our results provide mechanism for maintenance redpolls despite largely homogenized gene flow.

Language: Английский

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Metabolomic Profile and Antioxidant/Anti-Inflammatory Effects of Industrial Hemp Water Extract in Fibroblasts, Keratinocytes and Isolated Mouse Skin Specimens

Antioxidants, Journal Year: 2021, Volume and Issue: 10(1), P. 44 - 44

Published: Jan. 1, 2021

Industrial hemp is a multiuse crop whose phytocomplex includes terpenophenolics and flavonoids. In the present study, phenolic terpenophenolic compounds were assayed in water extract of variety Futura 75. Protective effects also investigated human fibroblast keratinocytes isolate mouse skin specimens, which exposed to hydrogen peroxide and/or (1–500 µg/mL). The results phytochemical analysis suggested cannabidiol, cannabidiolic acid rutin as prominent phytocompounds. vitro system represented by fibroblasts, was found be able protect cells from cytotoxicity apoptosis induced oxidative stress. Moreover, modulatory on IL-6, key mediator proliferation, found. isolated rat skin, reduced peroxide-induced l-dopa turnover, prostaglandin-E2 production ratio kynurenine/tryptpophan, thus corroborating anti-inflammatory/antioxidant effects. silico docking studies highlighted putative interactions between with tyrosinase indoleamine-2,3-dioxygenase, involved turnover tryptophan conversion kynurenine, respectively. conclusion, findings showed efficacy protective agent. This could partly related content rutin.

Language: Английский

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