Macrophage plasticity, polarization, and function in health and disease

Journal of Cellular Physiology, Journal Year: 2018, Volume and Issue: 233(9), P. 6425 - 6440

Published: Jan. 10, 2018

Macrophages are heterogeneous and their phenotype functions regulated by the surrounding micro-environment. commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which pro-inflammatory polarized lipopolysaccharide (LPS) either alone association with Th1 cytokines such as IFN-γ, GM-CSF, produce interleukin-1β (IL-1β), IL-6, IL-12, IL-23, TNF-α; 2) Alternatively M2 anti-inflammatory immunoregulatory Th2 IL-4 IL-13 IL-10 TGF-β. macrophages have different transcriptional profiles. They unique abilities destroying pathogens repair inflammation-associated injury. It is known that M1/M2 macrophage balance polarization governs fate of an organ inflammation When infection severe enough to affect organ, first exhibit release TNF-α, IL-1β, IL-23 against stimulus. But, if phase continues, it can cause tissue damage. Therefore, secrete high amounts TGF-β suppress inflammation, contribute repair, remodeling, vasculogenesis, retain homeostasis. In this review, we discuss basic biology including origin, differentiation activation, distribution, plasticity polarization, migration, antigen presentation capacity, cytokine chemokine production, metabolism, involvement microRNAs function. Secondly, protective pathogenic role subsets normal pathological pregnancy, anti-microbial defense, anti-tumor immunity, metabolic disease obesity, asthma allergy, atherosclerosis, fibrosis, wound healing, autoimmunity.

Language: Английский

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Skin Acute Wound Healing: A Comprehensive Review

International Journal of Inflammation, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 15

Published: June 2, 2019

Experimental work of the last two decades has revealed general steps wound healing process. This complex network been organized in three sequential and overlapping steps. The first step inflammatory phase is an immediate response to injury; primary sensory neurons sense injury send danger signals brain, stop bleeding start inflammation. following target phase, led by peripheral blood mononuclear cells, eliminate pathogens clean wound. Once this completed, resolved homeostasis restored. aim proliferative second repair damage begin tissue remodeling. Fibroplasia, reepithelialization, angiogenesis, nerve are central actions phase. Lastly, objective final complete remodeling restore skin integrity. review provides present day information regarding status participant extracellular matrix, cytokines, chemokines, growth factors, as well their interactions with microenvironment during

Language: Английский

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Innate immunity in tuberculosis: host defense vs pathogen evasion

Cellular and Molecular Immunology, Journal Year: 2017, Volume and Issue: 14(12), P. 963 - 975

Published: Sept. 11, 2017

Language: Английский

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Functions of ROS in Macrophages and Antimicrobial Immunity

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 313 - 313

Published: Feb. 19, 2021

Reactive oxygen species (ROS) are a chemically defined group of reactive molecules derived from molecular oxygen. ROS involved in plethora processes cells all domains life, ranging bacteria, plants and animals, including humans. The importance for macrophage-mediated immunity is unquestioned. Their functions comprise direct antimicrobial activity against bacteria parasites as well redox-regulation immune signaling induction inflammasome activation. However, only few studies have performed in-depth analyses even fewer identified the precise redox-regulated target molecules. In this review, we will give brief introduction to their sources macrophages, summarize versatile roles indirect defense, provide an overview commonly used probes, scavengers inhibitors.

Language: Английский

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Immunometabolism at the interface between macrophages and pathogens

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(5), P. 291 - 304

Published: Jan. 24, 2019

Language: Английский

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Immune evasion and provocation by Mycobacterium tuberculosis

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(12), P. 750 - 766

Published: July 25, 2022

Language: Английский

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Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

Journal of Translational Medicine, Journal Year: 2017, Volume and Issue: 15(1)

Published: Feb. 15, 2017

Macrophages and neutrophils are key components involved in the regulation of numerous chronic inflammatory diseases, infectious disorders, especially certain autoimmune disease. However, little is known regarding contribution these cells to pathogenesis disorders. Recent studies have aimed clarify important factors affecting immunogenicity cells, including type dose antigen, microenvironment cell-antigen encounter, number, subset, phenotype which can prevent or induce responses. This review highlights role macrophage subsets injured tissues, supporting their cooperation during diseases.

Language: Английский

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Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Science Translational Medicine, Journal Year: 2020, Volume and Issue: 12(530)

Published: Feb. 12, 2020

Solid tumors elicit a detectable immune response including the infiltration of tumor-associated macrophages (TAMs). Unfortunately, this is co-opted into contributing toward tumor growth instead preventing its progression. We seek to reestablish an antitumor by selectively targeting surface receptors and endogenous signaling processes macrophage subtypes driving cancer RP-182 synthetic 10-mer amphipathic analog host defense peptides that induces conformational switch mannose receptor CD206 expressed on TAMs displaying M2-like phenotype. RP-182-mediated activation in human murine elicits program endocytosis, phagosome-lysosome formation, autophagy reprograms M1-like In syngeneic autochthonous models, suppressed growth, extended survival, was effective combination partner with chemo- or checkpoint therapy. Antitumor activity also observed CD206high patient-derived xenotransplantation models. Mechanistically, via selective reduction immunosuppressive TAMs, improved adaptive innate responses, increased cell phagocytosis reprogrammed TAMs.

Language: Английский

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Iron in infection and immunity

Molecular Aspects of Medicine, Journal Year: 2020, Volume and Issue: 75, P. 100864 - 100864

Published: May 24, 2020

Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both invading pathogens and mammalian cells including those of the immune system require iron to sustain their function, metabolism proliferation. On one hand, microbial uptake linked virulence most human pathogens. other sequestration from bacteria microorganisms efficient strategy host defense in line with principles 'nutritional immunity'. acute infection, host-driven withdrawal inhibits growth Chronic activation due persistent autoimmune disease or malignancy however, sequesters not only agents, autoreactive lymphocytes neoplastic but also erythroid progenitors. This key mechanisms which collectively result anemia chronic inflammation. this review, we highlight important interconnections between immunity, focusing on against relevant infections clinical consequences

Language: Английский

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CNS Demyelination with TNF-α Blockers

Current Neurology and Neuroscience Reports, Journal Year: 2017, Volume and Issue: 17(4)

Published: March 21, 2017

Language: Английский

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