Immunological harmony: the dynamic influence of cellular and humoral immunity on pregnancy success DOI Creative Commons
Manoj K. Pandey

Discover Immunity., Journal Year: 2024, Volume and Issue: 1(1)

Published: Aug. 20, 2024

Abstract This study is a crucial step in understanding the dynamics of maternal immune response directed at paternal human leukocyte antigen (HLA) molecules. HLA molecules are proteins on cell surfaces that play critical role system regulation. Our findings focus pivotal antibodies targeting fetal inhibiting antigen-induced activation uterine cells, which essential for successful pregnancies. Antibodies produced by recognize and neutralize foreign substances. The primary to unravel anti-fetal rejection drawing parallels transplant emphasizing allorecognition—the process an individual’s recognizes responds antigens from another individual same species—in both cellular (involving cells) humoral antibodies) refusal. Although exploring anti-HLA preventing loss patients with recurrent spontaneous abortion captivating, there still significant knowledge gaps need be addressed. Further studies imperative reveal precise mechanism these generate prevent responses, determinants pregnancy outcomes. It vital investigate specificity whether they exclusively target specific trophoblasts (cells forming outer layer blastocyst, providing nutrients embryo). review paper not only offers insights into development protective but also lays foundation future research therapeutic implications, particularly cases abortion.

Language: Английский

A multi-tissue metabolome atlas of primate pregnancy DOI Creative Commons
Dainan Yu, Haifeng Wan, Chao Tong

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(3), P. 764 - 781.e14

Published: Feb. 1, 2024

Language: Английский

Citations

17
The Role of Chronic Inflammation in Pediatric Cancer DOI Open Access

Christine Mella,

Panogiotis Tsarouhas,

Maximillian Brockwell

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(1), P. 154 - 154

Published: Jan. 6, 2025

Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result tissue fibrosis genetic alterations that contribute to pathogenesis of human diseases such as cancer. Recent scientific advancements exploring underlying mechanisms malignant cellular transformations cancer progression have exposed significant disparities between pediatric adult-onset cancers. For instance, cancers tend lower mutational burdens arise actively developing tissues, where cell-cycle dysregulation leads gene, chromosomal, fusion gene development not seen counterparts. As such, findings adult cannot be directly applied cancers, unique mutations inherent etiologies remain poorly understood. Here, we review processes chromosomal instability, tumor microenvironment, tumorigenesis transformation explore current therapeutic interventions maintain and/or restore inflammatory homeostasis.

Language: Английский

Citations

2
Macrophage plasticity and function in cancer and pregnancy DOI Creative Commons

Tingxuan Yin,

Xinyi Li, Yanhong Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

As the soil of life, composition and shaping process immune microenvironment uterus is worth exploring. Macrophages, indispensable constituents innate system, are essential mediators inflammation tissue remodeling as well. Recent insights into heterogeneity macrophage subpopulations have renewed interest in their functional diversity both physiological pathological settings. Macrophages display remarkable plasticity switch from one phenotype to another. Intrinsic enables macrophages perform a variety functions response changing contexts, such cancer pregnancy. The make particularly intriguing cells given dichotomous role either attacking or protecting tumors semi-allogeneic fetuses, which characterized functionally by immunomodulation neovascularization. Here, we reviewed compared novel perspectives on biology these two settings, including origin, phenotype, differentiation, roles corresponding microenvironments, informed recent studies identity function, well mechanisms that might offer opportunities for new therapeutic strategies malignancy pregnancy complications.

Language: Английский

Citations

9
Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance DOI Creative Commons
Jiali Yu,

Yijian Yan,

Shasha Li

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(17), P. 4713 - 4732.e19

Published: July 4, 2024

Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human types the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune checkpoint. We showed that genetic deficiency of resulted activation fetal resorption allogeneic pregnancy models. Analogously, contributed to MPA/DMBA-induced breast progression, accompanied by CD8

Language: Английский

Citations

8
Early Life Stress Detection Using Physiological Signals and Machine Learning Pipelines DOI Creative Commons
Zeinab Shahbazi,

Yung-Cheol Byun

Biology, Journal Year: 2023, Volume and Issue: 12(1), P. 91 - 91

Published: Jan. 6, 2023

Pregnancy and early childhood are two vulnerable times when immunological plasticity is at its peak exposure to stress may substantially raise health risks. However, separate the effects of adversity during lifetime from those across entire lifespan, we require deeper phenotyping. Stress one challenges which everyone can face with this issue. It a type feeling contains mental pressure comes daily life matters. There many research investments regarding problem overcome or control complication. susceptible period for child mother taking affect child's after birth. The following matter happen based on natural disasters, war, death separation parents, etc. Early Life (ELS) has connection psychological development metabolic cardiovascular diseases. In research, main focus pregnancy healthy group women that risk future disease their pregnancy. This study looked relationship between retrospective recollections hardship inflammatory imbalance in 53 low-income, ethnically diverse who were seeking family-based trauma treatment experiencing interpersonal violence. Machine learning Convolutional Neural Networks (CNNs) applied detection using short-term physiological signals terms non-linear short term. concepts heart rate, hand foot galvanic skin response.

Language: Английский

Citations

12
Multimodal profiling of term human decidua demonstrates immune adaptations with pregravid obesity DOI Creative Commons
Suhas Sureshchandra, Brianna M. Doratt, Heather True

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(7), P. 112769 - 112769

Published: July 1, 2023

Leukocyte diversity of the first-trimester maternal-fetal interface has been extensively described; however, immunological landscape term decidua remains poorly understood. We therefore profiled human leukocytes from collected via scheduled cesarean delivery. Relative to first trimester, our analyses show a shift NK cells and macrophages T enhanced immune activation. Although circulating decidual are phenotypically distinct, they demonstrate significant clonotype sharing. also report within macrophages, frequency which positively correlates with pregravid maternal body mass index. Interestingly, ability respond bacterial ligands is reduced obesity, suggestive skewing toward immunoregulation as possible mechanism safeguard fetus against excessive inflammation. These findings resource for future studies investigating pathological conditions that compromise fetal health reproductive success.

Language: Английский

Citations

12
Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage DOI Creative Commons
Linlin Wang, Zhinang Yin,

Yanqiong Shen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 13, 2024

Immune dysfunction in early pregnancy including overactivation of cytotoxic CD16

Language: Английский

Citations

4
Single-cell RNA sequencing of estrual mice reveals PM2.5-induced uterine cell heterogeneity and reproductive toxicity DOI Creative Commons
Shuyin Duan, Yong‐Fei Zheng, Jiaqi Tian

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116968 - 116968

Published: Sept. 4, 2024

Language: Английский

Citations

4
Monocyte and Macrophage in Follicular Liquid: Predictive Markers of Embryo Quality in Women with Obesity and Infertility DOI Creative Commons

Evgeny D. Merkulov,

Anastasia V. Prozorova, Ю. Г. Самойлова

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 22, 2025

Background: Over the past five years, pregnancy rate in assisted reproductive technology (ART) programs Russia has remained relatively stable. The aim of this study was to assess distribution monocyte and macrophage subsets blood follicular fluid infertile women undergoing technology. Methods: involved 45 with a mean age 35 ± 4.66 years. Monocytes macrophages were identified using flow cytometry. Results: We observed decrease CD68+CD163+CD206+ CD68+CD163–CD206+ cells patients body mass index (BMI) >25 by 0.19 times 6.56 times, respectively, compared group BMI <25 (p = 0.031). Patients fair oocyte quality had 3.6 more oocytes than those poor 0.010). relative content CD14+163–206+ monocytes found be 24.15 higher embryo good embryos also noted that number increased male factor infertility 0.020) unspecified when tubal infertility. An increase CD14+163+206+ other causes female M2-monocytes (CD14+163+206–) 4.38 unexplained Conclusions: A critical component inflammatory reaction vitro fertilization (IVF) involves just activation pro-inflammatory response ovarian stimulation. Our research shows changes can influence implantation success outcomes women. These processes are influenced various infertility-related factors, including mentioned above. However, these findings preliminary require further investigation.

Language: Английский

Citations

0
Macrophages: a double-edged sword in female reproduction and disorders DOI Creative Commons

Mira Park,

Yeon Sun Kim,

Haengseok Song

et al.

Experimental & Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Reproduction consists of sequential inflammation-like events, primarily within the endometrium, from ovulation to embryo implantation, decidualization and delivery. During reproductive cycle, endometrium repeatedly undergoes cyclic periods proliferation, differentiation, tissue breakdown repair without scarring. Owing their phagocytic activity, macrophages, key players in innate immunity, are thought play crucial roles endometrium. Endometrial macrophages actively participate various stages remodeling, particularly during pregnancy establishment. Traditionally considered simple bystanders that clear debris prevent autoimmune responses homeostasis, now recognized as main actors with broad functional plasticity allows them fine tune balance between pro- anti-inflammatory inflammation, remodeling repair. Homeostatic is determined by sum mediators produced two distinctly polarized macrophage subpopulations. The biased polarization tissue-resident may contribute pathogenesis diseases, such inflammation cancer. Thus, understanding how endometrial homeostasis for deciphering underlying mechanisms disorders. Nanomedicines using extracellular vesicles, nanoparticles noncoding RNAs have recently been applied modulate alleviate disease phenotypes. Despite these advances, functions under physiological pathophysiological conditions remain poorly understood, which complicates development targeted therapies. Here we update current homeostatic function putative contribution dysfunction disorders women, along innovative molecular therapeutics resolve this issue.

Language: Английский

Citations

0