Lysozyme/N-GQD loaded carboxymethyl cellulose hydrogels for healing of excision wounds in Drosophila and Sprague Dawley rats

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141638 - 141638

Published: March 1, 2025

Language: Английский

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Laser-scribed Flexible Interdigitated Electrodes using DIY Laser Engraver and Electrodeposition of Polyaniline and Silver for pH Monitoring

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137634 - 137634

Published: March 1, 2025

Language: Английский

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A microfluidic wearable device for wound exudate management and analysis in human chronic wounds

Science Translational Medicine, Journal Year: 2025, Volume and Issue: 17(795)

Published: April 23, 2025

Chronic wounds are a major global health challenge associated with substantial economic burden and negative impact on patient quality of life. Real-time analysis biomarkers like reactive oxygen nitrogen species could guide treatment, but existing systems lack the capacity required for continuous monitoring. Wound exudate is secreted slowly has complex composition, making efficient fluid collection real-time challenging. To address these issues, we introduce iCares, wearable device wound management in situ biomarkers. iCares contains flexible nanoengineered sensor array that measures such as NO, H 2 O , along pH temperature, providing multiparameter data to inform status. The features pump-free triad microfluidic modules superhydrophobic-superhydrophilic Janus membrane, bioinspired wedge channels, three-dimensional graded micropillars unidirectional collection, transport, refreshing. sensors demonstrated consistent response analyte selectivity vitro exudate. was designed rapid scalable manufacturing through advanced printing laser patterning. Wireless connectivity supported long-term monitoring wounds. system tested murine model diabetic skin during infection antimicrobial treatment. Clinical evaluation conducted 20 patients chronic two before after surgery. A machine learning multiplexed successfully classified healing times, indicating by offer insight into status aid treatment decisions.

Language: Английский

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Bench to Bedside Evaluation of an Innovative, Non‐Bordered Foam Dressing for Use in Exudating Chronic Wounds

International Wound Journal, Journal Year: 2025, Volume and Issue: 22(S1)

Published: April 1, 2025

ABSTRACT To investigate a dimpled, non‐bordered foam dressing with soft silicone wound contact layer, the research spans from bench (fluid handling performance) to bedside (clinical effectiveness on exuding chronic wounds). In vitro methodology was used monitor fluid capacity and retention of investigational compared other commercially available dressings according standard EN 13726:2023. provide complementary clinically relevant results, more advanced laboratory tests were conducted using FLUHTE (FLUid Handling Test Equipment) simulator. paired clinical investigation, moderately highly wounds patients had applied as part management regime, healing‐related parameters assessed for up six weeks. The significantly outperformed in dispersion ability. Overall, performed well terms handling, including under compression. use associated substantial improvement, reductions size exudate levels, improved patient quality life scores. At final visit, nine (13.2%) that healed. There no adverse device effects reported. Data highlighted impact design performance. effectively handled fluid, even when subjected mechanical forces mimicking those it would be setting. results support various origins.

Language: Английский

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Laboratory Evaluations of Wound Dressings: Key Advances to Reflect Clinical Reality

International Wound Journal, Journal Year: 2025, Volume and Issue: 22(S1)

Published: April 1, 2025

ABSTRACT Laboratory evaluations are essential for determining the safety and effectiveness of wound dressings. These assist clinicians in selecting optimal products their patients. It is crucial that laboratory tests closely mimic real clinical conditions. This review highlights collaboration between scientists, industry experts to improve testing methods The goal ensure relevant real‐world use. Key advancements include a new simulated fluid handling test system better reflects actual care environments. improvements aim support more reliable, evidence‐based decisions practice.

Language: Английский

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Reconfiguring the endogenous electric field of a wound through the conductive hydrogel for effective exudate management to enhance skin wound healing

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

In this work, we proposed a mechanism for hydrogel-based dressings to respond endogenous electric fields through exudate absorption and conducted verification study using polyacrylamide sodium alginate (PAM–SA) hydrogels.

Language: Английский

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Conhecimentos em enfermagem sobre feridas

Revista Eletrônica Acervo Saúde, Journal Year: 2024, Volume and Issue: 24(12), P. e17867 - e17867

Published: Dec. 29, 2024

Objetivo: Analisar o conhecimento de acadêmicos e profissionais enfermagem sobre feridas em todos os níveis atenção à saúde. Métodos: Trata-se uma revisão integrativa da literatura, realizada nas bases dados MEDLINE, LILACS BDENF. Foram elencados oito artigos completos, publicados entre 2019 a 2023. Resultados: Verificou-se escassez publicações atuais assunto, principalmente internacionais. Entre estudos analisados, foi evidenciado deficiência no tanto dos quanto enfermagem, condição que ressalta necessidade mais pesquisas na área, especialmente aquelas se concentrem estratégias ensino teórico-prático, além iniciativas educação continuada, já essas atitudes podem impactar significativamente habilidades cuidado pessoas com diferentes Considerações Finais: Esta pesquisa contribuiu para geração novas ideias perspectivas ao frente às feridas, aprofundar as evidências apresentadas. Assim, principais pontos do tema foram discutidos objetivo proposto atingido através análise reflexão incluídos revisão.

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