Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102519 - 102519
Published: Nov. 16, 2024
Language: Английский
Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 11, 2025
Bimetallic inorganic nanoparticles are vital due to their high biocompatibility, stability and comparatively less toxicity. Nanosized bimetallic oxide materials have been extensively studied worldwide unique properties such as electrical, magnetic mechanical properties. Present work is reporting the size-controlled synthesis of strontium aluminate magnesium cobaltate (SrAl2O4 MgCoO2) by self-propagating combustion reaction using polymer fuel. Size prepared SrAl2O4 MgCoO2 samples distributed on DLS spectrum was 76 nm 100 respectively. The structural morphological characterization nano were carried out X-ray diffraction (XRD) scanning electron microscope (SEM) analysis It shows crystalline compact nature samples. FT-IR instrumentation used study bonding both Formation metal metal–metal can supports sample formation. EDX further confirm presence Sr, Al, Mg Co metals also characteristics absorption peaks signals demonstrate final phases UV–vis spectroscopic fluorescence undertaken know emission behaviour In continuation, thermal electrochemical studies analyzed. Thermal investigation assesses samples, which stability. preliminary results CV concluding that, electro active show possible applications. insights gained from this contribute growing body knowledge in nanomaterials pave way for innovations electrical thermal-related technologies.
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 11, 2025
Effective treatment of diabetic wounds remains challenging because multidrug-resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue-adhesive antibacterial hydrogel incorporating MXene deferoxamine (DFO)-loaded microspheres is developed for the MDR bacteria-infected wounds. The built based on covalent crosslinking between ε-poly(L-lysine) o-phthalaldehyde-terminated four-arm poly(ethylene glycol). exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, biodegradability. Under near-infrared (NIR) irradiation, converted light into heat elevated local temperature rapidly, enabling rapid disintegration biofilms. Simultaneously, exerted inherent activity, persistently killing planktonic bacteria, effectively controlling wound infections. encapsulated DFO then released from in sustained controlled manner, promoted angiogenesis during healing. Additionally, MXenes can scavenge reactive oxygen species alleviate inflammation. methicillin-resistant Staphylococcus aureus-infected model mice, composite along with NIR irradiation efficiently reduced infectious accelerated healing by promoting alleviating This has great clinical potential wounds, particularly environments involving motion infection.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 366 - 366
Published: March 13, 2025
Chronic wounds pose a significant healthcare challenge, impacting millions of patients worldwide and burdening systems substantially. These often occur as comorbidities are prone to infections. Such infections hinder the healing process, complicating clinical management proving recalcitrant therapy. The environment within wound itself poses challenges such lack oxygen, restricted blood flow, oxidative stress, ongoing inflammation, bacterial presence. Traditional systemic treatment for chronic peripheral may not be effective due inadequate supply, resulting in unintended side effects. Furthermore, topical applications impervious persistent biofilm A growing concern is therapeutic modalities treating wounds. Additionally, chemically harsh microenvironment can reduce effectiveness treatments, highlighting need drug delivery that deliver therapies precisely where needed with optimal dosages. Compared cell-based therapies, exosome-based offer distinct advantages cell-free approach treatment. Exosomes endosomal origin enable cell-to-cell communications, they possess benefits, including biocompatibility decreased immunogenicity, making them ideal vehicles efficient targeting minimizing off-target damage. However, exosomes rapidly cleared from body, it difficult maintain concentrations at sites. hydrogel-based development biocompatible scaffolds beneficial sustained release prolong presence these Engineered have been shown stability promoting compared their unmodified counterparts. Significant progress has made this field, but further research essential unlock potential. This review seeks explore benefits opportunities wounds, ensuring efficacy precise despite obstacles posed by environment.
Language: Английский
Citations
1
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 9, 2024
Since wound healing is one of the most important medical challenges and common dressings have not been able to manage this challenge well today, efforts increased achieve an advanced dressing. Mesenchymal stem cells exosomes derived from them shown high potential in regenerating wounds due their immunomodulatory, anti-inflammatory, immunosuppressive, regenerative capacities. However, such as short life these cells, low durability area, stability resulted limitations use for healing. Nowadays, different scaffolds are considered suitable biomaterials These made natural or synthetic polymers promising ideal dressing that does disadvantages dressings. One strategies has attracted much attention today using seeding delivering MSCs exosomes. This combined strategy a enhancing shelf increasing In review, combination with comprehensively discussed.
Language: Английский
Citations
5
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11321 - 11341
Published: Nov. 1, 2024
Background: Conventional wound dressings often adhere to wounds and can cause secondary injury due their lack of anti-inflammatory antibacterial properties. In contrast, collagen-based nanoparticles (NPs) as drug delivery systems exhibit both biocompatibility biodegradability, presenting a promising avenue for accelerating healing processes. Aims Study: This review aims provide comprehensive overview the mechanisms involved in healing, description attributes ideal dressings, understanding efficacy collagen, exploring NPs-mediated therapy, detailing synthesis fabrication techniques NPs, delineating applications various NPs infused on healing. Methodology: synthesizes relevant literature from reputable databases such Scopus, Science Direct, Google Scholar, PubMed. Results: A diverse array including nanopolymers, metal nanoemulsions, nanoliposomes, nanofibers, demonstrate pronounced promoting closure tissue regeneration. The incorporation has not only become an agent therapeutics but also actively contributes cascade. Conclusion: conclusion, brief, use presents compelling strategy expediting Keywords: nanoparticles, techniques, collagen
Language: Английский
Citations
4
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 362, P. 123656 - 123656
Published: April 27, 2025
Language: Английский
Citations
0
Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100719 - 100719
Published: May 23, 2025
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 289 - 326
Published: April 11, 2025
Nanofiber technology presents significant potential across various medical applications, with particular emphasis on its role in wound healing. This chapter examines the ability of nanofibers to mimic extracellular matrix, facilitating critical processes such as cell adhesion, migration, nutrient and oxygen delivery, inflammation modulation, controlled release bioactive molecules. These properties position optimal candidates for advanced dressings, biodegradable scaffolds, cell-seeded constructs. Empirical studies substantiate their efficacy mitigating inflammation, preventing infections, minimizing scar formation. However, challenges persist, including issues related scalability, cost-effectiveness, mechanical stability, biocompatibility, regulatory approval. concludes by addressing these outlining research gaps that must be bridged fully harness nanofiber technology, particularly long-term safety, mechanistic insights, adaptation low-resource settings.
Language: Английский
Citations
0
Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102519 - 102519
Published: Nov. 16, 2024
Language: Английский
Citations
2